Strain Summary(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1

Strain Name

 (BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1

Strain Type(s)

 other

Strain Synonym(s)

 (BALB/cByJ _ C57BL/6J)F1 _ (C3H/HeJ _ DBA/2J)F1  •  (BALB/cByJ X C57BL/6J)F1 mothers (JAX #100,009) and (C3H/HeJ X DBA/2J)F1 fathers (JAX #100,004)  •  (BALB/cByJ x C57BL/6J)F1 mothers (JAX stock 100009) and (C3H/HeJ x DBA/2J)F1 fathers (JAX stock 100004)  •  (BALB/cByJ x C57BL/6J)F1 X (C3H/HeJ x DBA/2J)F1  •  F2 of (BALB/cByJ x C57BL/6J)F1 X (C3H/HeJ x DBA/2J)F1  •  Het3  •  HET3  •  UM HET3  •  UM-HET3

Description

 These mice were generated by breeding CByB6F1/J female mice ((BALB/cByJ x C57BL/6J)F1) (JAX Stock No: 100009) with C3D2F1/J male mice ((C3H/HeJ x DBA/2J)F1) (JAX Stock No: 100004). [NOTE: The BALB in this version of UM-HET3 mice is BALB/cByJ.]

Models

96 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adipose tissue liposarcoma Adipose tissue

0

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Adipose tissue liposarcoma Adipose tissue rapamycin

2.27

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Adrenal gland - Cortex hyperplasia Adrenal gland - Cortex

0

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Adrenal gland - Cortex hyperplasia Adrenal gland - Cortex canagliflozin (Cana)

0

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Adrenal gland - Cortex neoplasia Adrenal gland - Cortex

0

38.5

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Adrenal gland - Cortex neoplasia Adrenal gland - Cortex 16alpha-hydroxyestradiol (OH_Est)

7.7

11.1

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Adrenal gland - Cortex neoplasia Adrenal gland - Cortex canagliflozin (Cana)

6.9

20.7

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Adrenal gland - Cortex neoplasm Adrenal gland - Cortex

0

26

References: Snyder JM, Geroscience 2023;45(1):385-397

Adrenal gland - Cortex neoplasm Adrenal gland - Cortex canagliflozin (Cana)

7.7

6.7

References: Snyder JM, Geroscience 2023;45(1):385-397

Adrenal gland - Subcapsular cell hyperplasia - spindle cell Adrenal gland - Subcapsular cell

0

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Adrenal gland - Subcapsular cell hyperplasia - spindle cell Adrenal gland - Subcapsular cell canagliflozin (Cana)

0

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Adrenal gland carcinoma Adrenal gland

0 - 4.35

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Adrenal gland hyperplasia Adrenal gland

observed

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Adrenal gland hyperplasia Adrenal gland rapamycin

observed

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Blood neoplasia Blood

31

14

References: Snyder JM, Geroscience 2023;45(1):385-397

Blood neoplasia Blood canagliflozin (Cana)

31

13

References: Snyder JM, Geroscience 2023;45(1):385-397

Blood vessel hemangiosarcoma Blood vessel

0 - 7.3

0 - 7.8

21.74

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201   ⋅   Snyder JM, Geroscience 2023;45(1):385-397   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Blood vessel hemangiosarcoma Blood vessel rapamycin

13.64

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Blood vessel hemangiosarcoma Blood vessel canagliflozin (Cana)

5.1 - 16.7

6.5 - 14

References: Snyder JM, Geroscience 2023;45(1):385-397   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Blood vessel hemangiosarcoma Blood vessel 16alpha-hydroxyestradiol (OH_Est)

13.8

13.8

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Bone lesion - fibro-osseous Bone

7.1

0

4.8

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Bone lesion - fibro-osseous Bone 16alpha-hydroxyestradiol (OH_Est)

60.9

59.3

60

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Bone lesion - fibro-osseous Bone canagliflozin (Cana)

observed

observed

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

6.52

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast rapamycin

2.27

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Leukocyte lymphoma Leukocyte

32.61

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Leukocyte lymphoma Leukocyte rapamycin

18.18

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Liver - Hepatocyte hyperplasia Liver - Hepatocyte

9.1

24

References: Snyder JM, Geroscience 2023;45(1):385-397

Liver - Hepatocyte hyperplasia Liver - Hepatocyte canagliflozin (Cana)

6.8

17

References: Snyder JM, Geroscience 2023;45(1):385-397

Liver adenoma Liver

3.6

28.6

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Liver adenoma Liver 16alpha-hydroxyestradiol (OH_Est)

0

6.9

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Liver adenoma Liver canagliflozin (Cana)

6.9

3.3

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Liver carcinoma Liver

4.35

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Liver carcinoma Liver rapamycin

9.09

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Liver foci Liver

3.6

14

References: Snyder JM, Geroscience 2023;45(1):385-397

Liver foci Liver canagliflozin (Cana)

5.1

7.9

References: Snyder JM, Geroscience 2023;45(1):385-397

Liver hepatocellular adenoma Liver

7.3

9.8

References: Snyder JM, Geroscience 2023;45(1):385-397

Liver hepatocellular adenoma Liver canagliflozin (Cana)

8.5

16

References: Snyder JM, Geroscience 2023;45(1):385-397

Liver hepatocellular carcinoma Liver

1.8 - 13

7.1 - 7.8

References: Snyder JM, Geroscience 2023;45(1):385-397   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Liver hepatocellular carcinoma Liver canagliflozin (Cana)

0 - 1.7

4.8 - 30

References: Snyder JM, Geroscience 2023;45(1):385-397   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Liver hepatocellular carcinoma Liver 16alpha-hydroxyestradiol (OH_Est)

0

3.4 - 10

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Lung adenocarcinoma Lung

13.3

28.6

observed

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Lung adenocarcinoma Lung rapamycin

observed

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Lung adenocarcinoma Lung 16alpha-hydroxyestradiol (OH_Est)

7.1

3.4

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Lung adenocarcinoma Lung canagliflozin (Cana)

10

40

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Lung adenoma Lung

11

31

observed

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201   ⋅   Snyder JM, Geroscience 2023;45(1):385-397

Lung adenoma Lung canagliflozin (Cana)

14

27

References: Snyder JM, Geroscience 2023;45(1):385-397

Lung carcinoma Lung

1.8 - 6.7

6.7 - 12

15.22

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201   ⋅   Snyder JM, Geroscience 2023;45(1):385-397   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Lung carcinoma Lung rapamycin

34.09

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Lung carcinoma Lung canagliflozin (Cana)

5.1 - 6.7

7.9 - 22.6

References: Snyder JM, Geroscience 2023;45(1):385-397   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Lung carcinoma Lung 16alpha-hydroxyestradiol (OH_Est)

3.4

6.9

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Lung hyperplasia Lung

16

24

References: Snyder JM, Geroscience 2023;45(1):385-397

Lung hyperplasia Lung canagliflozin (Cana)

22

30

References: Snyder JM, Geroscience 2023;45(1):385-397

Mammary gland carcinoma Mammary gland

3.3

0

4.55 - 8.7

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Mammary gland carcinoma Mammary gland 16alpha-hydroxyestradiol (OH_Est)

10.3

0

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Mammary gland carcinoma Mammary gland canagliflozin (Cana)

16.7

0

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Mammary gland neoplasm Mammary gland

11.1

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Ovary cyst Ovary

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Ovary cyst Ovary canagliflozin (Cana)

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Ovary hyperplasia Ovary

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Ovary hyperplasia Ovary canagliflozin (Cana)

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Pancreas - Islet of Langerhans hyperplasia Pancreas - Islet of Langerhans

27

78

References: Snyder JM, Geroscience 2023;45(1):385-397

Pancreas - Islet of Langerhans hyperplasia Pancreas - Islet of Langerhans canagliflozin (Cana)

28

69

References: Snyder JM, Geroscience 2023;45(1):385-397

Pituitary gland neoplasm Pituitary gland

6.7

6.7

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Pituitary gland neoplasm Pituitary gland 16alpha-hydroxyestradiol (OH_Est)

29.6

3.6

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Pituitary gland neoplasm Pituitary gland canagliflozin (Cana)

10

0

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Skin - Melanocyte melanoma Skin - Melanocyte

0 - 2.27

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Skin carcinoma Skin

0 - 2.27

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Thymus thymoma Thymus

0

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Thymus thymoma Thymus rapamycin

2.27

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

6.5

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell canagliflozin (Cana)

0

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Thyroid gland - Follicular cell hyperplasia Thyroid gland - Follicular cell

11

4.3

References: Snyder JM, Geroscience 2023;45(1):385-397

Thyroid gland - Follicular cell hyperplasia Thyroid gland - Follicular cell canagliflozin (Cana)

24

14

References: Snyder JM, Geroscience 2023;45(1):385-397

Thyroid gland carcinoma Thyroid gland

2.17

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Thyroid gland carcinoma Thyroid gland rapamycin

0

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Thyroid gland hyperplasia Thyroid gland

17.4

0

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Thyroid gland hyperplasia Thyroid gland 16alpha-hydroxyestradiol (OH_Est)

0

22.2

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Uterus - Endometrium carcinoma Uterus - Endometrium

observed

References: Miller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Uterus - Endometrium hyperplasia Uterus - Endometrium

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

0 - observed

References: Snyder JM, Geroscience 2023;45(1):385-397   ⋅   Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium canagliflozin (Cana)

0

References: Snyder JM, Geroscience 2023;45(1):385-397

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium 16alpha-hydroxyestradiol (OH_Est)

observed

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia (Unspecified organ)

50

6.7

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia Head

13.3

0

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia Uterus

37.9

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia Liver

40.7

15.4

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia (Unspecified organ) 16alpha-hydroxyestradiol (OH_Est)

44.8

20.7

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia Head 16alpha-hydroxyestradiol (OH_Est)

0

7.1

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia Uterus 16alpha-hydroxyestradiol (OH_Est)

14.8

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia (Unspecified organ) canagliflozin (Cana)

20

22.6

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia Uterus canagliflozin (Cana)

13.8

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) neoplasia Liver canagliflozin (Cana)

16.7

30

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) squamous cell carcinoma (Unspecified organ)

0

0

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) squamous cell carcinoma (Unspecified organ) 16alpha-hydroxyestradiol (OH_Est)

0

6.9

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797

(Unspecified organ) squamous cell carcinoma (Unspecified organ) canagliflozin (Cana)

3.3

0

References: Snyder JM, Geroscience 2026 Apr;48(2):1787-1797