Strain SummaryB6.129S2-Trp53tm1Tyj/J
Strain Name |
B6.129S2-Trp53tm1Tyj/J |
Strain Type(s) |
congenic • targeted mutation (knockout) |
Strain Synonym(s) |
B6.129S2-Trp53tm1Tyj • B6.129S2-Trp53tm1Tyj • C57BL/6J-Trp53tm1Tyj • C57BL/6J-Trp53tm1Tyj • p53+/- • p53+/- • p53 heterozygous (+/-) • p53+/- • p53(+/-) |
Description |
Heterozygous mice. The genetic background of these mice is congenic C57BL/6J. |
Strain Links |
• JAX Mice |
Strain Genetics |
Trp53tm1Tyj / Trp53+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Blood vessel hemangiosarcoma | Subcutis |
observed |
References: Mikaelian I, Personal Communication 2004;(): 7 pathology image(s) |
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CNS - Brain - Undifferentiated cell medulloblastoma | CNS - Brain - Cerebellum |
observed |
References: Summers BA, Personal Communication 2004;(): 10 pathology image(s) |
|||||
CNS - Brain glioma | CNS - Brain | retrovirus expressing human PDGFB |
100 |
References: Deng Q, Nat Commun 2019 Nov 7;10(1):5061 |
||||
Esophagus hyperplasia | Esophagus | zinc-deficient |
moderate |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus hyperplasia | Esophagus |
very low |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
|||||
Esophagus tumor | Esophagus | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
0 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus tumor | Esophagus | N-nitrosomethylbenzylamine (NMBA) |
0 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach - Squamocolumnar junction with the glandular stomach tumor | Forestomach - Squamocolumnar junction with the glandular stomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
88 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach - Squamocolumnar junction with the glandular stomach tumor | Forestomach - Squamocolumnar junction with the glandular stomach | N-nitrosomethylbenzylamine (NMBA) |
19 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach hyperplasia | Forestomach | zinc-deficient |
moderate |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach hyperplasia | Forestomach |
very low |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
|||||
Forestomach squamous cell carcinoma | Forestomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
13 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach tumor | Forestomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
69 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach tumor | Forestomach | N-nitrosomethylbenzylamine (NMBA) |
6.3 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Leukocyte - Lymphocyte lymphoma | Leukocyte - Lymphocyte |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte lymphoma | Thymus | zinc-deficient |
10 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Leukocyte lymphoma | Thymus |
0 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
|||||
Liver hepatocellular carcinoma | Liver | aflatoxin B1 (AFB1) (AFB1) |
10 |
References: McGlynn KA, Cancer Res 2003 Aug 1;63(15):4594-601 |
||||
Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Mesodermal cell/mesoblast sarcoma - undifferentiated | Subcutis |
observed |
References: Mikaelian I, Personal Communication 2004;(): 11 pathology image(s) |
|||||
Muscle - Striated - Skeletal rhabdomyosarcoma - poorly differentiated | Muscle - Striated - Skeletal |
observed |
References: Mikaelian I, Personal Communication 2004;(): 9 pathology image(s) |
|||||
(Unspecified organ) carcinoma | (Unspecified organ) |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
(Unspecified organ) tumor | (Unspecified organ) |
52 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |