Strain SummaryB6.129S2-Trp53tm1Tyj/J
Strain Name |
B6.129S2-Trp53tm1Tyj/J |
Strain Type(s) |
congenic • targeted mutation (knockout) |
Strain Synonym(s) |
B6.129S2-Trp53tm1Tyj • B6.129S2-Trp53tm1Tyj • C57BL/6J-Trp53tm1Tyj • p53-/- • p53 null (-/-) • p53-/- • p53-/- • p53 KO • p53-/- |
Description |
Homozygous mice. The genetic background of these mice is congenic C57BL/6J. |
Strain Links |
• JAX Mice |
Strain Genetics |
Trp53tm1Tyj / Trp53tm1Tyj |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
CNS - Brain glioma | CNS - Brain | retrovirus expressing human PDGFB |
100 |
References: Deng Q, Nat Commun 2019 Nov 7;10(1):5061 |
||||
Esophagus - Glandular metaplasia | Esophagus - Glandular | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
19 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus - Glandular metaplasia | Esophagus - Glandular | N-nitrosomethylbenzylamine (NMBA) |
0 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus hyperplasia | Esophagus | zinc-deficient |
very high |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus hyperplasia | Esophagus | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
observed |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus hyperplasia | Esophagus |
moderate |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
|||||
Esophagus squamous cell carcinoma | Esophagus | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
9.5 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus tumor | Esophagus | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
38 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Esophagus tumor | Esophagus | N-nitrosomethylbenzylamine (NMBA) |
0 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach - Squamocolumnar junction with the glandular stomach hyperplasia | Forestomach - Squamocolumnar junction with the glandular stomach | zinc-deficient |
very high |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach - Squamocolumnar junction with the glandular stomach hyperplasia | Forestomach - Squamocolumnar junction with the glandular stomach |
moderate |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
|||||
Forestomach - Squamocolumnar junction with the glandular stomach papilloma | Forestomach - Squamocolumnar junction with the glandular stomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
observed |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach - Squamocolumnar junction with the glandular stomach tumor | Forestomach - Squamocolumnar junction with the glandular stomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
100 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach - Squamocolumnar junction with the glandular stomach tumor | Forestomach - Squamocolumnar junction with the glandular stomach | N-nitrosomethylbenzylamine (NMBA) |
74 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach hyperplasia | Forestomach | zinc-deficient |
very high |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach hyperplasia | Forestomach |
moderate |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
|||||
Forestomach papilloma | Forestomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
observed |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach squamous cell carcinoma | Forestomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
38 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach squamous cell carcinoma | Forestomach | N-nitrosomethylbenzylamine (NMBA) |
5.3 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach tumor | Forestomach | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
100 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Forestomach tumor | Forestomach | N-nitrosomethylbenzylamine (NMBA) |
42 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Leukocyte - Lymphocyte leukemia | Liver |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte - Lymphocyte lymphoma | Liver |
observed |
0 |
References: Mikaelian I, Personal Communication 2003;(): ⋅ Mukherjee M, PLoS One 2011;6(7):e22167 1 pathology image(s) |
||||
Leukocyte - Lymphocyte lymphoma | Leukocyte - Lymphocyte |
observed - 70 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte - Lymphocyte lymphoma | Thymus |
observed |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte - Lymphocyte lymphoma | Spleen |
observed |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte - Lymphocyte lymphoma | Lung |
observed |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte - Lymphocyte lymphoma | Kidney |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte - Lymphocyte lymphoma | Intestine - Large Intestine - Colon |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte - Lymphocyte lymphoma | Bone marrow |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Leukocyte lymphoma | Leukocyte | zinc-deficient |
40 - 70 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Leukocyte lymphoma | Thymus |
40 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
|||||
Leukocyte lymphoma | Thymus | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
4.3 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Leukocyte lymphoma | Leukocyte | N-nitrosomethylbenzylamine (NMBA) ⋅ zinc-deficient |
35 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Leukocyte lymphoma | Leukocyte | N-nitrosomethylbenzylamine (NMBA) |
16 |
References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95 |
||||
Liver hepatocellular carcinoma | Liver | aflatoxin B1 (AFB1) (AFB1) |
0 |
References: McGlynn KA, Cancer Res 2003 Aug 1;63(15):4594-601 |
||||
Lymphoid tissue lymphoma | Liver | aflatoxin B1 (AFB1) (AFB1) |
100 |
References: McGlynn KA, Cancer Res 2003 Aug 1;63(15):4594-601 |
||||
Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
50 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
Testis - Germ cell teratoma | Eye |
observed |
References: Smith RS, Comp Med 2002 Feb;52(1):68-72 |
|||||
(Unspecified organ) carcinoma | (Unspecified organ) |
0 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |
|||||
(Unspecified organ) tumor | (Unspecified organ) |
100 |
References: Mukherjee M, PLoS One 2011;6(7):e22167 |