Reference SummaryTorres-Arzayus MI, Cancer Cell 2004 Sep;6(3):263-74
Title |
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. | ||||||
Authors |
Torres-Arzayus MI; De Mora JF; Yuan J; Vazquez F; Bronson R; Rue M; Sellers WR; Brown M | ||||||
Journal |
Cancer Cell | ||||||
Volume |
6 | ||||||
Issue |
3 | ||||||
Year |
2004 | ||||||
Pages |
263-74 | ||||||
Abstract |
The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, abnormal postweaning involution, and the development of malignant mammary tumors. Tumors are also increased in other organs, including the pituitary and uterus. AIB1 overexpression increases mammary IGF-I mRNA and serum IGF-I protein levels. In addition, IGF-I receptor and downstream signaling molecules are activated in primary mammary epithelial cells and mammary tumor cells derived from AIB1-tg mice. Knockdown of AIB1 expression in cultured AIB1-tg mammary tumor cells leads to reduced IGF-I mRNA levels and increased apoptosis, suggesting that an autocrine IGF-I loop underlies the mechanism of AIB1-induced oncogenesis. | ||||||
Links |
J:93548 – MGI References 15380517 – National Library of Medicine/PubMed |
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Strain Notes
|
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Adrenal gland - Cortex tumor | Adrenal gland - Cortex |
2 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast |
6 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Leukocyte - Monocyte - Macrophage sarcoma | Bone |
2 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Leukocyte lymphoma | Leukocyte |
2 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Lung adenocarcinoma | Lung |
18 |
||
| FVB/NTac | Lung tumor | Lung |
2.9 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma | Mammary gland |
48 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - acinar | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - comedo | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - cribriform | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - ductal | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - lobular | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - microacinar | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - papillary | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland adenocarcinoma - solid/comedo | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland cyst - squamous | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
high |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland metaplasia - squamous | Mammary gland |
observed |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Mammary gland tumor | Mammary gland |
50 |
||
| FVB/NTac | Mammary gland tumor | Mammary gland |
0 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Muscle - Smooth leiomyosarcoma | Uterus |
18 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Ovary - Germ cell teratoma | Ovary - Germ cell |
3 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Pituitary gland adenoma | Pituitary gland |
42 |
||
| FVB/NTac | Pituitary gland tumor | Pituitary gland |
1.9 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Skin papilloma | Skin |
3 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | Skin squamous cell carcinoma | Skin |
1 |
||
| FVB/NTac-Tg(MMTV-NCOA3)#Mybr | (Unspecified organ) tumor | (Unspecified organ) |
76 - 80 |
||
| FVB/NTac | (Unspecified organ) tumor | (Unspecified organ) |
4.8 |