Reference SummaryMalkinson AM, Cancer Res 1997 Jul 15;57(14):2832-4
Title |
Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene. |
Authors |
Malkinson AM; Koski KM; Evans WA; Festing MF |
Journal |
Cancer Res |
Volume |
57 |
Issue |
14 |
Year |
1997 |
Pages |
2832-4 |
Abstract |
Chronic butylated hydroxytoluene (BHT) treatment after a single administration of a carcinogen increases lung tumor multiplicity in some inbred strains of mice. We report that BALB/cOla and BALB/cByJ mice given a low dose (10 microg/g of body weight) of 3-methylcholanthrene (MCA) develop no lung tumors unless this is followed by chronic BHT exposure. Slightly higher MCA doses (15 and 25 microg/g) induce low lung tumor multiplicities (0.6 and 1.9 tumors/mouse, respectively) that are increased 12-26-fold by chronic BHT administration. This low-dose MCA/BHT model in BALB mice will facilitate the identification of genes regulating susceptibility to lung tumor promotion and pulmonary chemopreventative agents that act at a postinitiation site. |
Links |
J:41834 – MGI References 9230183 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| BALB/cOla | Lung tumor |
|
Lung |
0 |
|
| BALB/cOla | Lung tumor |
|
Lung |
50 |
|
| BALB/cOla | Lung tumor |
|
Lung |
100 |
|
| BALB/cOla | Lung tumor |
|
Lung |
83 |
|
| BALB/cByJ | Lung tumor |
|
Lung |
0 - 47 |
|
| BALB/cByJ | Lung tumor |
|
Lung |
100 |
|
| BALB/cByJ | Lung tumor |
|
Lung |
75 |
|
| BALB/cByJ | Lung tumor |
|
Lung |
100 |