Reference SummaryHeussen GA, Toxicol Lett 1996 Nov;88(1-3):23-8

Title

 Carcinogenicity study of outdoor airborne particulate matter in newborn male NMRI mice.

Authors

 Heussen GA; van den Berg JH; Dreef-van der Meulen HC; Alink GM

Journal

 Toxicol Lett

Volume

 88

Issue

 1-3

Year

 1996

Pages

 23-8

Abstract

 An organic extract of airborne particulate matter (APM) was tested for carcinogenicity at two dose levels in the newborn mouse bioassay. The samples used were taken under specific polluted conditions. The doses tested corresponded with 0.75 and 1.5 times the amount of air man inhales during lifetime. Benzo(a)pyrene, which was used as a positive control, significantly increased the lung tumor incidence. No evidence was found for a carcinogenic activity of the organic extract of APM. Considering the high dose of APM applied in this animal model and the much lower actual cumulative dose to which man is exposed to in many areas, the conclusion can be drawn that exposure to APM alone probably does not represent an important cancer risk for man.

Links

 J:37505 – MGI References
8920712 – National Library of Medicine/PubMed

Strain Notes

Strain Note
NMRI Sometimes described as "hybrid".

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
NMRI Liver - Hepatocyte foci - hyperplastic
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Liver - Hepatocyte

observed
NMRI Liver hepatocellular adenoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Liver

observed
NMRI Lung - Alveolus adenoma Lung - Alveolus

15 - 17
NMRI Lung - Alveolus adenoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Lung - Alveolus

42
NMRI Lung - Alveolus adenoma
  • airborne particulate matter (APM)
 Lung - Alveolus

14 - 30
NMRI Lung - Alveolus carcinoma Lung - Alveolus

0
NMRI Lung - Alveolus carcinoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Lung - Alveolus

1.9
NMRI Lung - Alveolus carcinoma
  • airborne particulate matter (APM)
 Lung - Alveolus

0
NMRI Lung - Bronchiole adenoma Lung - Bronchiole

5.6 - 13
NMRI Lung - Bronchiole adenoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Lung - Bronchiole

12
NMRI Lung - Bronchiole adenoma
  • airborne particulate matter (APM)
 Lung - Bronchiole

4.1 - 11
NMRI Lung - Bronchiole carcinoma Lung - Bronchiole

0 - 1.9
NMRI Lung - Bronchiole carcinoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Lung - Bronchiole

1.9
NMRI Lung - Bronchiole carcinoma
  • airborne particulate matter (APM)
 Lung - Bronchiole

2.0 - 2.1
NMRI Lung tumor Lung

22 - 31
NMRI Lung tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Lung

40
NMRI Lung tumor
  • airborne particulate matter (APM)
 Lung

20 - 36