Reference SummaryBlackwell BN, Toxicol Pathol 1995 Sep-Oct;23(5):570-82
Title |
Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet. |
Authors |
Blackwell BN; Bucci TJ; Hart RW; Turturro A |
Journal |
Toxicol Pathol |
Volume |
23 |
Issue |
5 |
Year |
1995 |
Pages |
570-82 |
Abstract |
Groups of C57BL6 mice of each sex were assigned to one of 2 dietary regimens, ad libitum (AL) or dietary restriction (DR), to study effects of food restriction on body weight, survival, and neoplasia. The AL and DR groups were subdivided into a scheduled sacrifice group for examination at 6-mo intervals, and a lifetime group to provide longevity data. Necropsies and microscopic examinations were conducted on 911 animals. In the lifetime group food consumption averaged 33.6 and 34.4 g per week by AL males and AL females, respectively; the DR counterparts were given 40% less. The diet contained 4.35 kcal/g. The average lifetime body weights were 34.8, 26.8, 22.6, and 21.6 g for AL males, AL females, DR males, and DR females, respectively, and their age at 50% survival was 27.5, 26.9, 31.7, and 33.5 mo. Maximal lifespan was increased 18% in DR males and females. Lifetime incidence of tumor-bearing mice was 89% and 86% for AL males and females, versus 64% for each sex of DR mice. Dramatic reduction occurred in female DR mice in lymphoma (9% vs 29%), pituitary neoplasms (1% vs 37%), and thyroid neoplasms (0.4% vs 8%). In males, hepatocellular tumors were reduced to 1% from 10% by DR. In contrast, the incidence of histiocytic sarcoma was increased in DR females and unaffected in DR males. Tumor onset was delayed in DR animals; 87% of all neoplasms in males and 95% in females had occurred in the AL mice by 24 mo, whereas the DR animals had only 52% and 39% of their lifetime incidence, respectively, by that age. This study provided comparative AL and DR data from C57BL6 mice examined randomly at 6-mo intervals (cross-sectional group) in parallel with data from animals in similar cohort that was unsampled and allowed to succumb naturally (longevity group). Dietary restriction reduced the lifetime percentage of tumor-bearing animals and the number of tumors per animal, and delayed the age at onset of most neoplasms. |
Links |
J:30114 – MGI References 8578100 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6JNia | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
1.2 - 2.6 |
||
| C57BL/6NNia | Adrenal gland - Medulla pheochromocytoma |
|
Adrenal gland - Medulla |
0 - 6.7 |
|
| C57BL/6JNia | Adrenal gland adenoma | Adrenal gland |
3.7 |
||
| C57BL/6NNia | Adrenal gland adenoma |
|
Adrenal gland |
0.5 |
|
| C57BL/6NNia | Adrenal gland tumor |
|
Adrenal gland |
0.6 |
|
| C57BL/6JNia | Blood vessel tumor | Blood vessel |
0 - 7.1 |
||
| C57BL/6NNia | Blood vessel tumor |
|
Blood vessel |
0 - 6.7 |
|
| C57BL/6NNia | Bone - Nose osteosarcoma |
|
Bone - Nose |
1.1 |
|
| C57BL/6NNia | Bone - Skull osteoma |
|
Bone - Skull |
0.6 |
|
| C57BL/6NNia | Bone osteosarcoma |
|
Bone |
0 - 7.1 |
|
| C57BL/6NNia | Connective tissue - Fibroblast fibrosarcoma |
|
Skin |
0.6 |
|
| C57BL/6JNia | Eye - Harderian gland adenoma | Eye - Harderian gland |
0 - 7.1 |
||
| C57BL/6NNia | Eye - Harderian gland adenoma |
|
Eye - Harderian gland |
0 - 13 |
|
| C57BL/6JNia | Gallbladder papilloma | Gallbladder |
0 - 7.1 |
||
| C57BL/6NNia | Intestine - Small Intestine - Duodenum polyp |
|
Intestine - Small Intestine - Duodenum |
0 - 13 |
|
| C57BL/6NNia | Intestine - Small Intestine - Ileum polyp |
|
Intestine - Small Intestine - Ileum |
0.6 |
|
| C57BL/6JNia | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| C57BL/6JNia | Kidney adenoma | Kidney |
1.2 |
||
| C57BL/6NNia | Kidney adenoma |
|
Kidney |
0.5 |
|
| C57BL/6NNia | Kidney papilloma |
|
Kidney |
0.5 |
|
| C57BL/6JNia | Kidney tumor | Kidney |
0.6 |
||
| C57BL/6JNia | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 55 |
||
| C57BL/6NNia | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 50 |
|
| C57BL/6JNia | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0.9 |
||
| C57BL/6JNia | Leukocyte lymphoma | Leukocyte |
0 - 60 |
||
| C57BL/6NNia | Leukocyte lymphoma |
|
Leukocyte |
0 - 27 |
|
| C57BL/6JNia | Liver - Sinusoid - Ito cell tumor - benign | Liver - Sinusoid - Ito cell |
0.6 |
||
| C57BL/6JNia | Liver hepatocellular adenoma | Liver |
0 - 7.1 |
||
| C57BL/6NNia | Liver hepatocellular adenoma |
|
Liver |
0.5 - 1.1 |
|
| C57BL/6JNia | Liver hepatocellular carcinoma | Liver |
0 - 7.1 |
||
| C57BL/6NNia | Liver hepatocellular carcinoma |
|
Liver |
0.6 - 1.1 |
|
| C57BL/6JNia | Lung adenoma | Lung |
0 - 14 |
||
| C57BL/6NNia | Lung adenoma |
|
Lung |
0 - 6.7 |
|
| C57BL/6JNia | Lung carcinoma | Lung |
0 - 7.1 |
||
| C57BL/6NNia | Lung carcinoma |
|
Lung |
0.5 - 0.6 |
|
| C57BL/6JNia | Mammary gland carcinoma | Mammary gland |
3.4 |
||
| C57BL/6NNia | Mammary gland carcinoma |
|
Mammary gland |
0.6 |
|
| C57BL/6JNia | Mammary gland tumor - mixed | Mammary gland |
1.7 |
||
| C57BL/6JNia | Ovary adenoma | Ovary |
0.9 |
||
| C57BL/6NNia | Ovary adenoma |
|
Ovary |
1.1 |
|
| C57BL/6NNia | PNS - Schwann cell schwannoma |
|
Nose |
0 - 7.1 |
|
| C57BL/6NNia | PNS - Schwann cell schwannoma |
|
PNS - Schwann cell |
0.6 |
|
| C57BL/6NNia | PNS - Schwann cell schwannoma |
|
Eye |
0.6 |
|
| C57BL/6JNia | PNS - Schwann cell schwannoma | Urinary bladder |
0.6 |
||
| C57BL/6NNia | Pancreas - Islet of Langerhans adenoma |
|
Pancreas - Islet of Langerhans |
0.5 |
|
| C57BL/6JNia | Paranasal sinus polyp | Paranasal sinus |
0.6 |
||
| C57BL/6JNia | Parathyroid gland adenoma | Parathyroid gland |
0 - 7.1 |
||
| C57BL/6NNia | Parathyroid gland adenoma |
|
Parathyroid gland |
0.5 |
|
| C57BL/6JNia | Pituitary gland adenoma | Pituitary gland |
0 - 64 |
||
| C57BL/6NNia | Pituitary gland adenoma |
|
Pituitary gland |
0 - 6.7 |
|
| C57BL/6JNia | Pituitary gland tumor | Pituitary gland |
0 |
||
| C57BL/6NNia | Pituitary gland tumor |
|
Pituitary gland |
0 |
|
| C57BL/6NNia | Skin - Hair follicle - Basal cell trichoepithelioma |
|
Skin - Hair follicle - Basal cell |
0.6 |
|
| C57BL/6JNia | Stomach squamous cell papilloma | Stomach |
1.2 |
||
| C57BL/6JNia | Thymus thymoma | Thymus |
1.2 |
||
| C57BL/6JNia | Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
0 - 29 |
||
| C57BL/6JNia | Thyroid gland - Follicular cell carcinoma | Thyroid gland - Follicular cell |
1.7 |
||
| C57BL/6NNia | Thyroid gland - Follicular cell carcinoma |
|
Thyroid gland - Follicular cell |
0.6 |
|
| C57BL/6NNia | Thyroid gland tumor |
|
Thyroid gland |
0 |
|
| C57BL/6NNia | Urethra papilloma |
|
Urethra |
0.5 |
|
| C57BL/6NNia | Urinary bladder papilloma |
|
Urinary bladder |
0.5 |
|
| C57BL/6JNia | Uterus adenoma | Uterus |
1.7 |
||
| C57BL/6JNia | Uterus polyp | Uterus |
0 - 14 |
||
| C57BL/6NNia | Uterus polyp |
|
Uterus |
0 - 6.7 |
|
| C57BL/6NNia | Uterus tumor |
|
Uterus |
0 |
|
| C57BL/6JNia | Vagina carcinoma | Vagina |
0 - 7.1 |
||
| C57BL/6NNia | Vagina tumor - granular cell |
|
Vagina |
0.6 |
|
| C57BL/6JNia | (Unspecified organ) tumor | (Unspecified organ) |
12 - 100 |
||
| C57BL/6NNia | (Unspecified organ) tumor |
|
(Unspecified organ) |
0 - 69 |