Reference SummaryFrith CH, Lab Anim Sci 1983 Jun;33(3):273-86
Title |
Spontaneous lesions in virgin and retired breeder BALB/c and C57BL/6 mice. | ||||
Authors |
Frith CH; Highman B; Burger G; Sheldon WD | ||||
Journal |
Lab Anim Sci | ||||
Volume |
33 | ||||
Issue |
3 | ||||
Year |
1983 | ||||
Pages |
273-86 | ||||
Abstract |
Prevalences of neoplastic and nonneoplastic lesions were reported for 3,000 virgin and 800 retired breeder BALB/c and C57BL/6 mice, untreated and of both sexes. The most common nonneoplastic lesions in the BALB/c mice were: hepatic fatty metamorphosis, uterine hemosiderosis and mineralization, testicular atrophy, ovarian cysts, and adrenal subcapsular spindle cell hyperplasia. The most common neoplasms in the BALB/c mice were: pulmonary tumors, hepatocellular neoplasms, Harderian adenomas, and uterine polyps. Common nonneoplastic lesions in the C57BL/6 mice were: pulmonary lymphoid accumulations, hepatic fatty metamorphosis, multifocal aggregates of mononuclear cells in the liver, proteinaceous renal casts, uterine hemosiderosis, endometrial cystic hyperplasia, ovarian atrophy, ovarian cysts, and pituitary cysts. The most common neoplasms in the C57BL/6 mice were angiosarcomas and pituitary adenomas. Hematopoietic tumors were common in both strains. | ||||
Links |
J:27148 – MGI References 6876733 – National Library of Medicine/PubMed |
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Strain Notes
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| BALB/cStCrlfC3Hf/Nctr | Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
0 - 8.0 |
||
| C57BL/6JfC3Hf/Nctr | Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
0 - 0.6 |
||
| BALB/cStCrlfC3Hf/Nctr | Adrenal gland - Cortex carcinoma | Adrenal gland - Cortex |
observed |
||
| C57BL/6JfC3Hf/Nctr | Adrenal gland - Cortex carcinoma | Adrenal gland - Cortex |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Adrenal gland - Cortex hyperplasia | Adrenal gland - Cortex |
0 - 16 |
||
| C57BL/6JfC3Hf/Nctr | Adrenal gland - Cortex hyperplasia | Adrenal gland - Cortex |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | CNS - Brain - Astrocyte astrocytoma | CNS - Brain - Astrocyte |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Erythrocyte hyperplasia | Spleen |
0 - 6.8 |
||
| C57BL/6JfC3Hf/Nctr | Erythrocyte hyperplasia | Spleen |
0 - 7.9 |
||
| BALB/cStCrlfC3Hf/Nctr | Eye - Harderian gland adenoma | Eye - Harderian gland |
0 - 14 |
||
| C57BL/6JfC3Hf/Nctr | Eye - Harderian gland adenoma | Eye - Harderian gland |
0 - 4.9 |
||
| BALB/cStCrlfC3Hf/Nctr | Eye - Lacrimal gland hyperplasia - ductal | Eye - Lacrimal gland |
0 - 11 |
||
| C57BL/6JfC3Hf/Nctr | Eye - Lacrimal gland hyperplasia - ductal | Eye - Lacrimal gland |
0 - 20 |
||
| BALB/cStCrlfC3Hf/Nctr | Eye - Lacrimal gland tumor | Eye - Lacrimal gland |
0 |
||
| C57BL/6JfC3Hf/Nctr | Eye - Lacrimal gland tumor | Eye - Lacrimal gland |
0 |
||
| C57BL | Intestine - Small Intestine - Duodenum polyp | Intestine - Small Intestine - Duodenum |
observed |
||
| C57BL/6JfC3Hf/Nctr | Intestine polyp | Intestine |
0 - 1.6 |
||
| BALB/cStCrlfC3Hf/Nctr | Intestine polyp | Intestine |
0 - 3.2 |
||
| C57BL | Intestine tumor | Intestine |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Kidney - Cortex metaplasia - osseous | Kidney - Cortex |
1 |
||
| C57BL/6JfC3Hf/Nctr | Kidney - Cortex metaplasia - osseous | Kidney - Cortex |
1 |
||
| BALB/cStCrlfC3Hf/Nctr | Kidney adenocarcinoma | Kidney |
0 - 1.7 |
||
| BALB/cStCrlfC3Hf/Nctr | Kidney adenoma | Kidney |
0 - 1.1 |
||
| C57BL/6JfC3Hf/Nctr | Kidney tumor | Kidney |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | Leukocyte - Lymphocyte - B-lymphocyte lymphoma | Leukocyte - Lymphocyte - B-lymphocyte |
0 - 27 |
||
| C57BL/6JfC3Hf/Nctr | Leukocyte - Lymphocyte - B-lymphocyte lymphoma | Leukocyte - Lymphocyte - B-lymphocyte |
0 - 28 |
||
| BALB/cStCrlfC3Hf/Nctr | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 11 |
||
| C57BL/6JfC3Hf/Nctr | Leukocyte - Lymphocyte hyperplasia | Spleen |
0 - 8.0 |
||
| BALB/cStCrlfC3Hf/Nctr | Leukocyte - Lymphocyte lymphoma - lymphocytic | Leukocyte - Lymphocyte |
0 - 6.7 |
||
| C57BL/6JfC3Hf/Nctr | Leukocyte - Lymphocyte lymphoma - lymphocytic | Leukocyte - Lymphocyte |
0 - 3.6 |
||
| BALB/cStCrlfC3Hf/Nctr | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 1.7 |
||
| C57BL/6JfC3Hf/Nctr | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 5.5 |
||
| C57BL/6JfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell sarcoma - mast cell | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
0 - 7.1 |
||
| C57BL/6JfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
0 - 8.8 |
||
| BALB/cStCrlfC3Hf/Nctr | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
observed |
||
| C57BL/6JfC3Hf/Nctr | Liver hepatocellular carcinoma | Liver |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Liver hepatocellular tumor | Liver |
0 - 11 |
||
| C57BL/6JfC3Hf/Nctr | Liver hepatocellular tumor | Liver |
0 - 4.7 |
||
| BALB/cStCrlfC3Hf/Nctr | Lung tumor | Lung |
0 - 42 |
||
| C57BL/6JfC3Hf/Nctr | Lung tumor | Lung |
0 - 6.1 |
||
| BALB/cStCrlfC3Hf/Nctr | Mammary gland adenocarcinoma | Mammary gland |
0 - 2.7 |
||
| C57BL/6JfC3Hf/Nctr | Mammary gland tumor | Mammary gland |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | Muscle - Smooth leiomyoma | Uterus |
observed |
||
| C57BL/6JfC3Hf/Nctr | Myoepithelial cell myoepithelioma | Salivary gland |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | Myoepithelial cell myoepithelioma | Salivary gland |
0 - 1.2 |
||
| BALB/c | Myoepithelial cell myoepithelioma | Salivary gland - Parotid |
observed |
||
| C3H/HeN | Myoepithelial cell myoepithelioma | Salivary gland - Parotid |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 - 1.6 |
||
| C57BL/6JfC3Hf/Nctr | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | Ovary adenoma - tubular | Ovary |
0 - 0.5 |
||
| C57BL/6JfC3Hf/Nctr | Ovary adenoma - tubular | Ovary |
0 - 3.7 |
||
| BALB/cStCrlfC3Hf/Nctr | Ovary luteoma | Ovary |
0 - 0.8 |
||
| C57BL/6JfC3Hf/Nctr | Ovary luteoma | Ovary |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | PNS - Schwann cell myoblastoma - granular cell | Epididymis |
7.0 |
||
| BALB/cStCrlfC3Hf/Nctr | Pituitary gland adenoma | Pituitary gland |
0 |
||
| C57BL/6JfC3Hf/Nctr | Pituitary gland adenoma | Pituitary gland |
0 - 11 |
||
| BALB/cStCrlfC3Hf/Nctr | Reticular cell hyperplasia | Spleen |
0 - 5.4 |
||
| C57BL/6JfC3Hf/Nctr | Reticular cell hyperplasia | Spleen |
0 - 6.9 |
||
| C57BL/6JfC3Hf/Nctr | Salivary gland - Parotid hyperplasia - ductal | Salivary gland - Parotid |
0 - 4.2 |
||
| BALB/cStCrlfC3Hf/Nctr | Salivary gland - Parotid hyperplasia - ductal | Salivary gland - Parotid |
0 - 3.8 |
||
| C57BL/6JfC3Hf/Nctr | Salivary gland - Sublingual hyperplasia - ductal | Salivary gland - Sublingual |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | Salivary gland - Sublingual hyperplasia - ductal | Salivary gland - Sublingual |
0 - 2 |
||
| C57BL/6JfC3Hf/Nctr | Salivary gland - Submandibular hyperplasia - ductal | Salivary gland - Submandibular |
0 - 5.3 |
||
| BALB/cStCrlfC3Hf/Nctr | Salivary gland - Submandibular hyperplasia - ductal | Salivary gland - Submandibular |
0 - 7.6 |
||
| BALB/cStCrlfC3Hf/Nctr | Testis - Leydig cell (Interstitial cell) tumor | Testis - Leydig cell (Interstitial cell) |
0 - 1.7 |
||
| C57BL/6JfC3Hf/Nctr | Testis - Leydig cell (Interstitial cell) tumor | Testis - Leydig cell (Interstitial cell) |
0 - 0.5 |
||
| C57BL/6JfC3Hf/Nctr | Thyroid gland adenoma | Thyroid gland |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Thyroid gland adenoma | Thyroid gland |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Urinary bladder tumor | Urinary bladder |
0 |
||
| C57BL/6JfC3Hf/Nctr | Urinary bladder tumor | Urinary bladder |
0 |
||
| BALB/cStCrlfC3Hf/Nctr | Uterus - Endometrium hyperplasia - cystic | Uterus - Endometrium |
0 - 3.7 |
||
| C57BL/6JfC3Hf/Nctr | Uterus - Endometrium hyperplasia - cystic | Uterus - Endometrium |
0 - 30 |
||
| BALB/cStCrlfC3Hf/Nctr | Uterus adenocarcinoma | Uterus |
observed |
||
| BALB/cStCrlfC3Hf/Nctr | Uterus polyp | Uterus |
0 - 36 |
||
| C57BL/6JfC3Hf/Nctr | Uterus polyp | Uterus |
0 - 1.0 |
||
| BALB/cStCrlfC3Hf/Nctr | Vagina dysplasia | Vagina |
0 - 11 |
||
| C57BL/6JfC3Hf/Nctr | Vagina dysplasia | Vagina |
0 - 1.0 |
||
| BALB/cStCrlfC3Hf/Nctr | (Unspecified organ) angioma | (Unspecified organ) |
0 - 2.7 |
||
| C57BL/6JfC3Hf/Nctr | (Unspecified organ) angiosarcoma | (Unspecified organ) |
0 - 14 |
||
| BALB/cStCrlfC3Hf/Nctr | (Unspecified organ) angiosarcoma | (Unspecified organ) |
0 - 6.3 |