Reference SummaryBomhard E, Exp Toxicol Pathol 1993 Oct;45(5-6):269-89
Title |
Frequency of spontaneous tumours in NMRI mice in 21-month studies. | ||||
Authors |
Bomhard E | ||||
Journal |
Exp Toxicol Pathol | ||||
Volume |
45 | ||||
Issue |
5-6 | ||||
Year |
1993 | ||||
Pages |
269-89 | ||||
Abstract |
Tumours occurring in 900 male and 900 female mice of the strain NMRI (BOR: NMRI (SPF Han), breeder: Winkelmann, Borchen) employed as control groups in 18 different studies lasting for 21 months on average (study No. 8 for 20 months, study No. 5 for 24 months) were compiled on the basis of histopathology reports. 883 male and 874 female mice were evaluated. The remaining animals were unavailable due to autolysis. A total of 1522 tumours (689 in males, 833 in females) were seen in 1061 mice (493 males, 568 females), 830 of which were classified as malignant (318 in males, 512 in females). About 70% of all primary tumours were located in the haemolymophoreticular tissue, lungs, ovaries, adrenals and uterus. Average incidences of primary tumours found in the following organs were: haemolymphoreticular tissue 22.9%, lungs 21.6%, ovaries 12.1%, adrenals 6.9%, uterus 6.6%, liver 4.4%, Harderian gland 4.4%, pituitary 3.5%, mamma 3.3% and various other organs with a tumour frequency below 3%. Male mice exhibited markedly more tumours of the lungs, adrenals, liver and Harderian glands, while tumours of the haemolymphoreticular tissue and pituitary were predominant in females. A comparison of these data with those from preceding two-year or life-span studies using NMRI mice from other breeders revealed a certain increase in primary tumours of the adrenals, Harderian glands as well as pituitary. This result could be due to more frequent examinations. | ||||
Links |
J:237404 – MGI References 8312710 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
NMRI | Adipose tissue lipoma | Peritoneum - Mesentery |
0 - observed |
||
NMRI | Adipose tissue liposarcoma | Muscle - Striated - Skeletal |
0 - 0.1 |
||
NMRI | Adrenal gland - Cortex adenocarcinoma | Adrenal gland - Cortex |
0.3 - 0.6 |
||
NMRI | Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
1.3 - 8.6 |
||
NMRI | Adrenal gland - Medulla pheochromocytoma - benign | Adrenal gland - Medulla |
1.3 - 1.7 |
||
NMRI | Adrenal gland - Medulla pheochromocytoma - malignant | Adrenal gland - Medulla |
0 - 0.2 |
||
NMRI | Adrenal gland tumor | Adrenal gland |
2.9 - 11.1 |
||
NMRI | Blood vessel hemangioma | Blood vessel |
1.1 |
||
NMRI | Blood vessel hemangiosarcoma | Blood vessel |
1.4 - 1.5 |
||
NMRI | Blood vessel tumor | Blood vessel |
2.5 - 2.6 |
||
NMRI | Bone - Femur osteosarcoma | Bone - Femur |
0 - 0.3 |
||
NMRI | Bone osteosarcoma | Skin |
0 - 0.1 |
||
NMRI | Bone osteosarcoma | Tail |
0 - observed |
||
NMRI | Bone osteosarcoma | Intestine - Small Intestine |
0 - 0.1 |
||
NMRI | Bone osteosarcoma | Muscle - Striated - Skeletal |
0 - 0.3 |
||
NMRI | CNS - Brain meningioma | CNS - Brain |
0 - 0.1 |
||
NMRI | Connective tissue - Fibroblast fibroma | Tail |
observed |
||
NMRI | Connective tissue - Fibroblast fibroma | Muscle - Striated - Skeletal |
0 - 0.1 |
||
NMRI | Connective tissue - Fibroblast fibrosarcoma | Skin |
0.3 |
||
NMRI | Connective tissue - Fibroblast fibrosarcoma | Tail |
0 - observed |
||
NMRI | Connective tissue - Fibroblast fibrosarcoma | Epididymis |
0.1 |
||
NMRI | Connective tissue - Fibroblast fibrosarcoma | Ear - Outer ear |
0 - observed |
||
NMRI | Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast |
0 - observed |
||
NMRI | Epididymis tumor - granular cell - benign | Epididymis |
0.1 |
||
NMRI | Eye - Harderian gland adenocarcinoma | Eye - Harderian gland |
0.2 - 0.3 |
||
NMRI | Eye - Harderian gland adenoma | Eye - Harderian gland |
2.7 - 7.0 |
||
NMRI | Eye - Harderian gland tumor | Eye - Harderian gland |
2.7 - 6.0 |
||
NMRI | Intestine - Large Intestine polyp | Intestine - Large Intestine |
0 - 0.1 |
||
NMRI | Intestine - Small Intestine polyp - adenomatous | Intestine - Small Intestine |
0 - 0.1 |
||
NMRI | Kidney adenoma | Kidney |
0 - 0.3 |
||
NMRI | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Salivary gland |
0 - 0.1 |
||
NMRI | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0.1 - 0.5 |
||
NMRI | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - observed |
||
NMRI | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor - malignant | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell |
0 - 0.1 |
||
NMRI | Leukocyte leukemia | Leukocyte |
0 - 0.8 |
||
NMRI | Leukocyte lymphoma | Leukocyte |
9.4 - 35.2 |
||
NMRI | Liver hepatocellular adenoma | Liver |
0.7 - 4.2 |
||
NMRI | Liver hepatocellular carcinoma | Liver |
0.6 - 3.1 |
||
NMRI | Liver tumor | Liver |
1.5 - 7.3 |
||
NMRI | Lung adenoma | Lung |
7.7 - 14.1 |
||
NMRI | Lung carcinoma | Lung |
8.0 - 13.7 |
||
NMRI | Lung tumor | Lung |
15.6 - 27.6 |
||
NMRI | Mammary gland adenoacanthoma | Mammary gland |
0 - 0.6 |
||
NMRI | Mammary gland adenoma | Mammary gland |
0 - 0.3 |
||
NMRI | Mammary gland carcinoma | Mammary gland |
0 - 3.1 |
||
NMRI | Mammary gland carcinosarcoma | Mammary gland |
0 - 0.1 |
||
NMRI | Mammary gland tumor | Mammary gland |
3.3 |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Skin |
0.1 - 0.5 |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Subcutis |
0 - observed |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Tail |
0 - observed |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Liver |
0 - 0.2 |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Epididymis |
0.1 |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Uterus - Endometrium |
0.3 |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Vagina |
0.5 |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Peritoneum - Mesentery |
0 - observed |
||
NMRI | Mesodermal cell/mesoblast sarcoma | Serosa - Pelvic cavity |
0 - observed |
||
NMRI | Mesodermal cell/mesoblast sarcoma - pleomorphic | Skin |
0 - 0.3 |
||
NMRI | Mesodermal cell/mesoblast sarcoma - stromal | Uterus |
1.3 |
||
NMRI | Mesothelium mesothelioma - malignant | Mediastinum |
0 - observed |
||
NMRI | Mesothelium mesothelioma - malignant | Peritoneum - Mesentery |
0 - observed |
||
NMRI | Muscle - Smooth leiomyoma | Intestine - Large Intestine |
0 - 0.1 |
||
NMRI | Muscle - Smooth leiomyoma | Epididymis |
0.1 |
||
NMRI | Muscle - Smooth leiomyoma | Uterus |
0.9 |
||
NMRI | Muscle - Smooth leiomyoma | Vagina |
0.5 |
||
NMRI | Muscle - Smooth leiomyosarcoma | Intestine - Large Intestine |
0 - 0.1 |
||
NMRI | Muscle - Smooth leiomyosarcoma | Seminal vesicle |
0.1 |
||
NMRI | Muscle - Smooth leiomyosarcoma | Uterus |
0.8 |
||
NMRI | Oral cavity papilloma | Oral cavity |
0 - observed |
||
NMRI | Ovary - Interstitial cell tumor - benign | Ovary - Interstitial cell |
0.1 |
||
NMRI | Ovary - Luteal cell tumor - benign | Ovary - Luteal cell |
0.2 |
||
NMRI | Ovary - Sertoli cell tumor - benign | Ovary - Sertoli cell |
0.2 |
||
NMRI | Ovary adenoma | Ovary |
0.1 |
||
NMRI | Ovary adenoma - papillary | Ovary |
0.6 |
||
NMRI | Ovary adenoma - tubular | Ovary |
1.0 |
||
NMRI | Ovary luteoma | Ovary |
1.7 |
||
NMRI | Ovary tumor | Ovary |
12.1 |
||
NMRI | Ovary tumor - granulosa-theca cell - benign | Ovary |
7.0 |
||
NMRI | Ovary tumor - granulosa-theca cell - malignant | Ovary |
1.0 |
||
NMRI | Oviduct carcinoma | Oviduct |
observed |
||
NMRI | PNS - Schwann cell schwannoma - malignant | Skin |
0 - 0.1 |
||
NMRI | Pancreas - Islet of Langerhans adenoma | Pancreas - Islet of Langerhans |
0 - 0.5 |
||
NMRI | Parathyroid gland adenoma | Parathyroid gland |
0 - 0.6 |
||
NMRI | Pituitary gland adenoma | Pituitary gland |
0.9 - 6.5 |
||
NMRI | Preputial gland (male) cystadenoma | Preputial gland (male) |
observed |
||
NMRI | Prostate gland carcinoma | Prostate gland |
0.2 |
||
NMRI | Seminal vesicle tumor - granular cell - benign | Seminal vesicle |
0.1 |
||
NMRI | Skin - Epidermis - Basal cell carcinoma | Skin - Epidermis - Basal cell |
0 - 0.1 |
||
NMRI | Skin papilloma | Skin |
0 - 0.1 |
||
NMRI | Skin tumor | Skin |
0.6 - 1.4 |
||
NMRI | Stomach adenocarcinoma | Stomach |
0.2 - 0.7 |
||
NMRI | Stomach adenoma | Stomach |
0.1 - 1.0 |
||
NMRI | Stomach carcinoma - spindle cell | Stomach |
0 - 0.1 |
||
NMRI | Stomach papilloma | Stomach |
0.1 |
||
NMRI | Stomach polyp - adenomatous | Stomach |
0 - 0.1 |
||
NMRI | Stomach tumor | Stomach |
0.5 - 2.0 |
||
NMRI | Subcutis carcinoma - basosquamous | Subcutis |
0 - observed |
||
NMRI | Testis - Leydig cell (Interstitial cell) tumor - benign | Testis - Leydig cell (Interstitial cell) |
1.7 |
||
NMRI | Testis - Leydig cell (Interstitial cell) tumor - benign | Epididymis |
0.1 |
||
NMRI | Testis - Leydig cell (Interstitial cell) tumor - malignant | Testis - Leydig cell (Interstitial cell) |
0.5 |
||
NMRI | Testis - Rete testis adenoma | Testis - Rete testis |
0.1 |
||
NMRI | Testis - Seminiferous tubules - Sertoli cell tumor - benign | Testis - Seminiferous tubules - Sertoli cell |
0.2 |
||
NMRI | Testis adenoma - tubular | Testis |
0.2 |
||
NMRI | Testis tumor | Testis |
2.7 |
||
NMRI | Thymus thymoma - malignant | Thymus |
0 - observed |
||
NMRI | Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
0 - 0.5 |
||
NMRI | Thyroid gland - Follicular cell carcinoma | Thyroid gland - Follicular cell |
0 - 0.1 |
||
NMRI | Thyroid gland adenoma | Thyroid gland |
0 - 0.1 |
||
NMRI | Thyroid gland carcinoma | Thyroid gland |
0 - 0.1 |
||
NMRI | Thyroid gland cystadenoma - papillary | Thyroid gland |
0.1 |
||
NMRI | Urinary bladder transitional cell carcinoma | Urinary bladder |
0.1 - 0.3 |
||
NMRI | Urinary bladder tumor - benign | Urinary bladder |
0 - 0.2 |
||
NMRI | Urinary bladder tumor - stromal - benign | Urinary bladder |
0 - 0.1 |
||
NMRI | Uterus - Endometrium - Stroma polyp | Uterus - Endometrium - Stroma |
1.7 |
||
NMRI | Uterus adenocarcinoma | Uterus |
0.6 |
||
NMRI | Uterus adenoma | Uterus |
0.2 |
||
NMRI | Uterus polyp - glandular | Uterus |
0.2 |
||
NMRI | Uterus squamous cell carcinoma | Uterus |
0.1 |
||
NMRI | Uterus tumor | Uterus |
6.6 |
||
NMRI | Uterus tumor - benign | Uterus |
0.3 |
||
NMRI | (Unspecified organ) reticulum cell sarcoma | (Unspecified organ) |
0.1 - 0.2 |
||
NMRI | (Unspecified organ) tumor | (Unspecified organ) |
9.7 - 65.0 |
||
NMRI | (Unspecified organ) tumor - benign | (Unspecified organ) |
29.3 - 34.5 |
||
NMRI | (Unspecified organ) tumor - malignant | (Unspecified organ) |
32.0 - 50.5 |