Reference SummarySundberg JP, PLoS One 2014;9(12):e113582
Title |
Immune Status, Strain Background, and Anatomic Site of Inoculation Affect Mouse Papillomavirus (MmuPV1) Induction of Exophytic Papillomas or Endophytic Trichoblastomas. |
Authors |
Sundberg JP; Stearns TM; Joh J; Proctor M; Ingle A; Silva KA; Dadras SS; Jenson AB; Ghim SJ |
Journal |
PLoS One |
Volume |
9 |
Issue |
12 |
Year |
2014 |
Pages |
e113582 |
Abstract |
Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities. A laboratory mouse papillomavirus, MmuPV1 (formerly MusPV), was horizontally transmitted within an inbred colony of NMRI-Foxn1nu/Foxn1nu (nude; T cell deficient) mice of an unknown period of time. A ground-up, filtered papilloma inoculum was not capable of infecting C57BL/6J wild-type mice; however, immunocompetent, alopecic, S/RV/Cri-ba/ba (bare) mice developed small papillomas at injection sites that regressed. NMRI-Foxn1nu and B6.Cg-Foxn1nu, but not NU/J-Foxn1nu, mice were susceptible to MmuPV1 infection. B6 congenic strains, but not other congenic strains carrying the same allelic mutations, lacking B- and T-cells, but not B-cells alone, were susceptible to infection, indicating that mouse strain and T-cell deficiency are critical to tumor formation. Lesions initially observed were exophytic papillomas around the muzzle, exophytic papillomas on the tail, and condylomas of the vaginal lining which could be induced by separate scarification or simultaneous scarification of MmuPV1 at all four sites. On the dorsal skin, locally invasive, poorly differentiated tumors developed with features similar to human trichoblastomas. Transcriptome analysis revealed significant differences between the normal skin in these anatomic sites and in papillomas versus trichoblastomas. The primarily dysregulated genes involved molecular pathways associated with cancer, cellular development, cellular growth and proliferation, cell morphology, and connective tissue development and function. Although trichoepitheliomas are benign, aggressive tumors, few of the genes commonly associated with basal cell carcinoma or squamous cells carcinoma were highly dysregulated. |
Links |
J:217142 – MGI References 25474466 – National Library of Medicine/PubMed |
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
B6.Cg-Foxn1nu/J | Skin - Dorsal region carcinoma - basal |
|
Skin - Dorsal region |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Dorsal region carcinoma - basal |
|
Adipose tissue |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Dorsal region carcinoma - poorly differentiated |
|
Skin - Dorsal region |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Dorsal region lesion |
|
Skin - Dorsal region |
0 - observed |
|
NU/J | Skin - Dorsal region lesion |
|
Skin - Dorsal region |
0 - observed |
|
B6.Cg-Foxn1nu/J | Skin - Dorsal region lesion - malignant |
|
Skin - Dorsal region |
observed |
|
Swiss/RVCri-ba | Skin - Dorsal region papilloma |
|
Skin - Dorsal region |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Dorsal region papilloma |
|
Skin - Dorsal region |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Dorsal region squamous cell carcinoma |
|
Skin - Dorsal region |
observed |
|
C57BL/6J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
0 |
|
Swiss/RVCri-ba | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
observed |
|
NU/J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
0 |
|
B6.Cg-Foxn1nu/J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
observed |
|
NMRI-Foxn1nu | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
observed |
|
B6.129S2-Ighmtm1Cgn/J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
0 |
|
B6.129S7-Rag1tm1Mom/J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
observed |
|
B6.CB17-Prkdcscid/SzJ | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
observed |
|
NOD.CB17-Prkdcscid/J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
0 |
|
B6.129S2-Cd4tm1Mak/J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
0 |
|
B6.129S2-Cd8tm1Mak/J | Skin - Dorsal region tumor |
|
Skin - Dorsal region |
0 |
|
B6.Cg-Foxn1nu/J | Skin - Epidermis hyperplasia |
|
Skin - Epidermis |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Facial region lesion |
|
Skin - Facial region |
observed |
|
NU/J | Skin - Facial region lesion |
|
Skin - Facial region |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Facial region papilloma |
|
Skin - Facial region |
observed |
|
NMRI-Foxn1nu | Skin - Facial region papilloma |
|
Skin - Facial region |
observed |
|
B6.129S7-Rag1tm1Mom/J | Skin - Facial region papilloma |
|
Skin - Facial region |
observed |
|
B6.CB17-Prkdcscid/SzJ | Skin - Facial region papilloma |
|
Skin - Facial region |
observed |
|
C57BL/6J | Skin - Facial region tumor |
|
Skin - Facial region |
0 |
|
NU/J | Skin - Facial region tumor |
|
Skin - Facial region |
0 |
|
B6.Cg-Foxn1nu/J | Skin - Facial region tumor |
|
Skin - Facial region |
observed |
|
NMRI-Foxn1nu | Skin - Facial region tumor |
|
Skin - Facial region |
observed |
|
B6.129S2-Ighmtm1Cgn/J | Skin - Facial region tumor |
|
Skin - Facial region |
0 |
|
B6.129S7-Rag1tm1Mom/J | Skin - Facial region tumor |
|
Skin - Facial region |
observed |
|
B6.CB17-Prkdcscid/SzJ | Skin - Facial region tumor |
|
Skin - Facial region |
observed |
|
NOD.CB17-Prkdcscid/J | Skin - Facial region tumor |
|
Skin - Facial region |
0 |
|
B6.129S2-Cd4tm1Mak/J | Skin - Facial region tumor |
|
Skin - Facial region |
0 |
|
B6.129S2-Cd8tm1Mak/J | Skin - Facial region tumor |
|
Skin - Facial region |
0 |
|
B6.Cg-Foxn1nu/J | Skin - Hair follicle trichoblastoma |
|
Skin - Hair follicle |
observed |
|
NMRI-Foxn1nu | Skin - Hair follicle trichoblastoma |
|
Skin - Hair follicle |
observed |
|
B6.129S7-Rag1tm1Mom/J | Skin - Hair follicle trichoblastoma |
|
Skin - Hair follicle |
observed |
|
B6.CB17-Prkdcscid/SzJ | Skin - Hair follicle trichoblastoma |
|
Skin - Hair follicle |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Hair follicle trichoblastoma |
|
Skin - Dorsal region |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Head papilloma - exophytic |
|
Muzzle |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Tail lesion - epithelial |
|
Skin - Tail |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Tail papilloma |
|
Skin - Tail |
observed |
|
NMRI-Foxn1nu | Skin - Tail papilloma |
|
Skin - Tail |
observed |
|
B6.129S7-Rag1tm1Mom/J | Skin - Tail papilloma |
|
Skin - Tail |
observed |
|
NU/J | Skin - Tail papilloma |
|
Skin - Tail |
observed |
|
NMRI-Foxn1nu | Skin - Tail papilloma - exophytic |
|
Skin - Tail |
observed |
|
B6.Cg-Foxn1nu/J | Skin - Tail papilloma - exophytic |
|
Skin - Tail |
observed |
|
C57BL/6J | Skin - Tail tumor |
|
Skin - Tail |
0 |
|
B6.Cg-Foxn1nu/J | Skin - Tail tumor |
|
Skin - Tail |
observed |
|
NMRI-Foxn1nu | Skin - Tail tumor |
|
Skin - Tail |
observed |
|
B6.129S2-Ighmtm1Cgn/J | Skin - Tail tumor |
|
Skin - Tail |
0 |
|
B6.129S7-Rag1tm1Mom/J | Skin - Tail tumor |
|
Skin - Tail |
observed |
|
NOD.CB17-Prkdcscid/J | Skin - Tail tumor |
|
Skin - Tail |
0 |
|
B6.129S2-Cd4tm1Mak/J | Skin - Tail tumor |
|
Skin - Tail |
0 |
|
B6.129S2-Cd8tm1Mak/J | Skin - Tail tumor |
|
Skin - Tail |
0 |
|
B6.Cg-Foxn1nu/J | Skin gland - Sebaceous gland lesion |
|
Skin - Dorsal region |
0 |
|
B6.Cg-Foxn1nu/J | Skin hyperplasia |
|
Skin |
observed |
|
C57BL/6J | Skin lesion |
|
Skin |
0 |
|
NMRI-Foxn1nu | Skin papilloma |
|
Neck |
observed |
|
NMRI-Foxn1nu | Skin papilloma |
|
Leg |
observed |
|
B6.Cg-Foxn1nu/J | Skin papilloma - exophytic |
|
Skin |
observed |
|
B6.Cg-Foxn1nu/J | Vagina hyperplasia - mucosal |
|
Vagina |
observed |