Reference SummaryMattison J, Cancer Res 2010 Feb 1;70(3):883-95
Title |
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. |
Authors |
Mattison J; Kool J; Uren AG; de Ridder J; Wessels L; Jonkers J; Bignell GR; Butler A; Rust AG; Brosch M; Wilson CH; van der Weyden L; Largaespada DA; Stratton MR; Futreal PA; van Lohuizen M; Berns A; Collier LS; Hubbard T; Adams DJ |
Journal |
Cancer Res |
Volume |
70 |
Issue |
3 |
Year |
2010 |
Pages |
883-95 |
Abstract |
Comparative genomic hybridization (CGH) can reveal important disease genes but the large regions identified could sometimes contain hundreds of genes. Here we combine high-resolution CGH analysis of 598 human cancer cell lines with insertion sites isolated from 1,005 mouse tumors induced with the murine leukemia virus (MuLV). This cross-species oncogenomic analysis revealed candidate tumor suppressor genes and oncogenes mutated in both human and mouse tumors, making them strong candidates for novel cancer genes. A significant number of these genes contained binding sites for the stem cell transcription factors Oct4 and Nanog. Notably, mice carrying tumors with insertions in or near stem cell module genes, which are thought to participate in cell self-renewal, died significantly faster than mice without these insertions. A comparison of the profile we identified to that induced with the Sleeping Beauty (SB) transposon system revealed significant differences in the profile of recurrently mutated genes. Collectively, this work provides a rich catalogue of new candidate cancer genes for functional analysis. |
Links |
J:156861 – MGI References 20103622 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| B6FVBF1-Gt(ROSA)26Sortm1(sb11)Njen TgTn(sb-T2/Onc)#Dla | CNS - Brain glioma | CNS - Brain |
observed |
||
| FVB.129X1-Cdkn2atm1Cjs | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S7-Trp53tm1Brd | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.Cg-Cdkn2atm1Cjs Cdkn2atm1Rdp | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129P2-Cdkn2btm1Brn | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S-Cdkn1atm1Led Cdkn1btm1Mlf/+ | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S6-Cdkn1atm1Led | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S4-Cdkn1btm1Mlf/+ | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S4-Cdkn1btm1Mlf | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S-Cdkn1atm1Led Cdkn1btm1Mlf | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.Cg-Cdkn2atm1Cjs/+ Cdkn2atm1Rdp/+ | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S-Cdkn1atm1Led/+ Cdkn1btm1Mlf/+ | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129-Cdkn1atm1Led Cdkn2btm1Brn | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S-Cdkn1atm1Led/+ Cdkn1btm1Mlf | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S6-Cdkn1atm1Led/+ | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB.129S7-Trp53tm1Brd/+ | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| FVB | Leukocyte - Lymphocyte lymphoma |
|
Leukocyte - Lymphocyte |
observed |
|
| B6FVBF1-Gt(ROSA)26Sortm1(sb11)Njen TgTn(sb-T2/Onc)#Dla | Leukocyte - Lymphocyte lymphoma | Leukocyte - Lymphocyte |
observed |
||
| B6FVBF1-Gt(ROSA)26Sortm1(sb11)Njen TgTn(sb-T2/Onc)#Dla | Skin tumor | Skin |
observed |