Reference SummaryXiao W, Cancer Cell 2009 Aug 4;16(2):161-71
Title |
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. | ||||
Authors |
Xiao W; Hong H; Kawakami Y; Kato Y; Wu D; Yasudo H; Kimura A; Kubagawa H; Bertoli LF; Davis RS; Chau LA; Madrenas J; Hsia CC; Xenocostas A; Kipps TJ; Hennighausen L; Iwama A; Nakauchi H; Kawakami T | ||||
Journal |
Cancer Cell | ||||
Volume |
16 | ||||
Issue |
2 | ||||
Year |
2009 | ||||
Pages |
161-71 | ||||
Abstract |
Given its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, phospholipase C (PLC) is implicated in promoting cell growth. However, we found that PLC-beta3-deficient mice develop myeloproliferative disease, lymphoma, and other tumors. The mutant mice have increased numbers of hematopoietic stem cells with increased proliferative, survival, and myeloid-differentiative abilities. These properties are dependent on Stat5 and can be antagonized by the protein phosphatase SHP-1. Stat5-dependent cooperative transformation by active c-Myc and PLC-beta3 deficiency was suggested in mouse lymphomas in PLC-beta3(-/-) and in Emicro-myc;PLC-beta3(+/-) mice and human Burkitt's lymphoma cells. The same mechanism for malignant transformation seems to be operative in other human lymphoid and myeloid malignancies. Thus, PLC-beta3 is likely a tumor suppressor. | ||||
Links |
J:151972 – MGI References 19647226 – National Library of Medicine/PubMed |
||||
Strain Notes
|
|||||
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| [not specified]-Plcb3tm1Dwu | Abdominal cavity hamartoma | Abdominal cavity |
0.8 |
||
| [not specified]-Plcb3tm1Dwu | Abdominal cavity tumor | Abdominal cavity |
0.8 |
||
| [not specified]-Tg(IghMyc)22Bri | Leukocyte - Lymphocyte - B-lymphocyte lymphoma | Leukocyte - Lymphocyte - B-lymphocyte |
observed |
||
| [not specified]-Plcb3tm1Dwu/+ Tg(IghMyc)22Bri | Leukocyte - Lymphocyte - Pre-B-lymphocyte lymphoma | Leukocyte - Lymphocyte - Pre-B-lymphocyte |
observed |
||
| [not specified]-Plcb3tm1Dwu | Leukocyte - Lymphocyte - T-lymphocyte lymphoma | Leukocyte - Lymphocyte - T-lymphocyte |
observed |
||
| [not specified]-Plcb3tm1Dwu | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
89 |
||
| C57BL/6J-Ptpn6me-v/J | Leukocyte - Myelocyte (Granulocyte) hyperplasia | Leukocyte - Myelocyte (Granulocyte) |
observed |
||
| [not specified]-Plcb3tm1Dwu | Leukocyte lymphoma | Leukocyte |
12.5 |
||
| [not specified]-Plcb3tm1Dwu | Leukocyte lymphoma | Thymus |
10.2 |
||
| [not specified]-Plcb3tm1Dwu | Leukocyte lymphoma | Lymph node |
2.3 |
||
| [not specified]-Plcb3tm1Dwu | Lung carcinoma | Lung |
1.6 |
||
| [not specified]-Plcb3tm1Dwu | Ovary - Germ cell teratoma | Ovary - Germ cell |
0.8 |
||
| [not specified]-Plcb3tm1Dwu | Skin carcinoma | Neck |
0.8 |
||
| [not specified]-Plcb3tm1Dwu | (Unspecified organ) tumor | (Unspecified organ) |
17 |
||
| [not specified]-Plcb2tm1Dwu | (Unspecified organ) tumor | (Unspecified organ) |
0 |