Reference SummaryNakamura K, Jikken Dobutsu 1992 Jul;41(3):279-85

Title

 [Age-related incidence of spontaneous tumors in SPF C57BL/6 and BDF1 mice]

Authors

 Nakamura K; Kuramoto K; Shibasaki K; Shumiya S; Ohtsubo K

Journal

 Jikken Dobutsu

Volume

 41

Issue

 3

Year

 1992

Pages

 279-85

Abstract

 Incidence of spontaneous tumors in C57BL/6 NCrj (CR), C5BL/6 CrSlc (SL) and B 6 Crj x DBA/2 NCrj F1 (BD) mice, which were reared under a barrier system and died natural death, were examined. Cohorts of mice in 200 to 300 each were purchased at 4 weeks of age and raised under SPF conditions. A large portion of the mice were used for various experiments between 3 and 30 months old while not a small number died before use and were autopsied. Median survival periods of the female and male were estimated at 697 and 680 days for CR, 764 and 806 days for SL and 866 and 929 days for BD, respectively. Incidence of spontaneous neoplastic lesions in the autopsied animals were 77.4% and 79.2% of 535 female and 590 male CR, 69.7% and 55.1% of 502 female and 463 male SL, and 75.8% and 78.0% of 298 female and 346 male BD, respectively. In CR, histiocytic sarcoma was the most predominant tumor, accounting for 72.1% of all tumors. In SL, malignant lymphoma was the most prevailing, forming 62.3%, and, in male BD, hepatocellular carcinoma was the most frequent, accounting for 41.8% of all tumors.

Links

 J:1341 – MGI References
1324182 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6CrSlc Blood vessel hemangioma Blood vessel

1.1 - 1.8
C57BL/6NCrlj Blood vessel hemangioma Blood vessel

0.3
(C57BL/6NCrlj x DBA/2NCrlj)F1 Blood vessel hemangioma Blood vessel

1.7 - 2.0
C57BL/6CrSlc Eye - Harderian gland adenoma Eye - Harderian gland

0.2
C57BL/6NCrlj Eye - Harderian gland adenoma Eye - Harderian gland

0.2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Eye - Harderian gland adenoma Eye - Harderian gland

0.9
C57BL/6CrSlc Intestine tumor Intestine

0.4
C57BL/6CrSlc Kidney tumor Kidney

0.2 - 0.4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Kidney tumor Kidney

2.0
C57BL/6CrSlc Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

6.3 - 9.2
C57BL/6NCrlj Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

54 - 66
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

11 - 25
C57BL/6J Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

51
C57BL/6CrSlc Leukocyte lymphoma Leukocyte

37 - 53
C57BL/6NCrlj Leukocyte lymphoma Leukocyte

12 - 21
(C57BL/6NCrlj x DBA/2NCrlj)F1 Leukocyte lymphoma Leukocyte

22 - 39
C57BL/6J Leukocyte lymphoma Leukocyte

0
C57BL/6CrSlc Liver hepatocellular carcinoma Liver

1.8 - 9.5
C57BL/6NCrlj Liver hepatocellular carcinoma Liver

0.4 - 2.0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Liver hepatocellular carcinoma Liver

5.7 - 40
C57BL/6J Liver hepatocellular carcinoma Liver

8.8
C57BL/6CrSlc Lung carcinoma Lung

2.8 - 6.3
C57BL/6NCrlj Lung carcinoma Lung

1.5 - 1.9
(C57BL/6NCrlj x DBA/2NCrlj)F1 Lung carcinoma Lung

4.4 - 14
C57BL/6J Lung carcinoma Lung

11
C57BL/6CrSlc Mammary gland tumor Mammary gland

0.8
C57BL/6NCrlj Mammary gland tumor Mammary gland

0.4
(C57BL/6NCrlj x DBA/2NCrlj)F1 Mammary gland tumor Mammary gland

2.7
C57BL/6CrSlc Ovary tumor Ovary

0.6
(C57BL/6NCrlj x DBA/2NCrlj)F1 Ovary tumor Ovary

0.7
C57BL/6CrSlc Pituitary gland adenoma Pituitary gland

0.4 - 6.2
C57BL/6NCrlj Pituitary gland adenoma Pituitary gland

0 - 1.9
(C57BL/6NCrlj x DBA/2NCrlj)F1 Pituitary gland adenoma Pituitary gland

0.6 - 5.7
C57BL/6J Pituitary gland adenoma Pituitary gland

0
C57BL/6CrSlc Skin tumor Skin

0.4 - 2.8
C57BL/6NCrlj Skin tumor Skin

0 - 2.2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Skin tumor Skin

0.3 - 4.3
C57BL/6J Skin tumor Skin

0
C57BL/6NCrlj Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

1.0
(C57BL/6NCrlj x DBA/2NCrlj)F1 Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

0.3
C57BL/6CrSlc Uterus tumor Uterus

0.2
C57BL/6NCrlj Uterus tumor Uterus

0.2
(C57BL/6NCrlj x DBA/2NCrlj)F1 Uterus tumor Uterus

1.3
C57BL/6CrSlc (Unspecified organ) tumor (Unspecified organ)

0.4 - 0.8
C57BL/6NCrlj (Unspecified organ) tumor (Unspecified organ)

0.4 - 0.8
(C57BL/6NCrlj x DBA/2NCrlj)F1 (Unspecified organ) tumor (Unspecified organ)

0.3 - 2.3
C57BL/6J (Unspecified organ) tumor (Unspecified organ)

10