Reference SummaryDawe CJ, Am J Pathol 1987 May;127(2):243-61
Title |
Variations in polyoma virus genotype in relation to tumor induction in mice. Characterization of wild type strains with widely differing tumor profiles. |
Authors |
Dawe CJ; Freund R; Mandel G; Ballmer-Hofer K; Talmage DA; Benjamin TL |
Journal |
Am J Pathol |
Volume |
127 |
Issue |
2 |
Year |
1987 |
Pages |
243-61 |
Abstract |
The authors have explored the effects of variations in mouse polyoma virus genotype on patterns of tumor formation in the mouse. Four 'wild type' virus strains were surveyed. Two were highly oncogenic, inducing multiple tumors of epithelial and mesenchymal origin, at high frequency and with short latency. The other two strains were weakly oncogenic, inducing fewer tumors, solely of mesenchymal origin, and after a long latency. These sharply contrasting tumor profiles were reproduced with virus stocks derived from molecularly cloned viral genomes. Though vastly different in their oncogenic properties, these cloned viruses proved equally effective in transforming established rat fibroblasts in culture and showed the same patterns of tumor antigen expression in cultured mouse cells. Complexes of polyoma middle T antigen and pp60c-src were demonstrated in extracts of epithelial tumors induced by a highly oncogenic virus strain. It is concluded that polyoma viral genetic determinants for tumor induction in the mouse are more complex than those previously defined by the use of cell transformation systems. |
Links |
J:101642 – MGI References 2437801 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C3H/BiDa | Adipose tissue liposarcoma |
|
Subcutis |
observed |
|
| C3H/BiDa | Adrenal gland - Medulla tumor |
|
Adrenal gland - Medulla |
observed - 9.4 |
|
| C3H/BiDa | Adrenal gland - Medulla tumor |
|
Adrenal gland - Medulla |
0 |
|
| C3H/BiDa | Adrenal gland - Medulla tumor |
|
Adrenal gland - Medulla |
observed |
|
| C3H/BiDa | Adrenal gland - Medulla tumor |
|
Adrenal gland - Medulla |
0 |
|
| C3H/BiDa | Adrenal gland - Medulla tumor |
|
Adrenal gland - Medulla |
2.7 - 5.4 |
|
| C3H/BiDa | Adrenal gland - Medulla tumor - epithelial |
|
Adrenal gland - Medulla |
observed |
|
| C3H/BiDa | Blood vessel hemangioma |
|
Blood vessel |
0 - 3.1 |
|
| C3H/BiDa | Blood vessel hemangioma |
|
Blood vessel |
13.3 |
|
| C3H/BiDa | Blood vessel hemangioma |
|
Blood vessel |
0 |
|
| C3H/BiDa | Blood vessel hemangioma |
|
Blood vessel |
0 |
|
| C3H/BiDa | Blood vessel hemangioma |
|
Blood vessel |
0 |
|
| C3H/BiDa | Blood vessel hemangioma |
|
Blood vessel |
0 - 7.7 |
|
| C3H/BiDa | Blood vessel hemangioma |
|
Blood vessel |
9.1 |
|
| C3H/BiDa | Blood vessel hemangioma - cavernous |
|
Blood vessel |
observed |
|
| C3H/BiDa | Blood vessel tumor |
|
Blood vessel |
16.7 |
|
| C3H/BiDa | Blood vessel tumor - mesenchymal |
|
Blood vessel |
observed |
|
| C3H/BiDa | Bone tumor |
|
Bone |
18.8 |
|
| C3H/BiDa | Bone tumor |
|
Bone |
0 |
|
| C3H/BiDa | Bone tumor |
|
Bone |
52.2 |
|
| C3H/BiDa | Bone tumor |
|
Bone |
4.5 |
|
| C3H/BiDa | Bone tumor |
|
Bone |
0 |
|
| C3H/BiDa | Bone tumor |
|
Bone |
25 - 50 |
|
| C3H/BiDa | Bone tumor |
|
Bone |
36.4 |
|
| C3H/BiDa | Bone tumor - mesenchymal |
|
Bone |
observed |
|
| C3H/BiDa | Bulbourethral gland tumor |
|
Bulbourethral gland |
0 - 6.2 |
|
| C3H/BiDa | Bulbourethral gland tumor |
|
Bulbourethral gland |
0 |
|
| C3H/BiDa | Bulbourethral gland tumor |
|
Bulbourethral gland |
observed |
|
| C3H/BiDa | Bulbourethral gland tumor |
|
Bulbourethral gland |
0 |
|
| C3H/BiDa | Bulbourethral gland tumor |
|
Bulbourethral gland |
0 - 2.7 |
|
| C3H/BiDa | Bulbourethral gland tumor - epithelial |
|
Bulbourethral gland |
observed |
|
| C3H/BiDa | Connective tissue - Fibroblast fibrosarcoma |
|
Subcutis |
observed |
|
| C3H/BiDa | Connective tissue tumor - mesenchymal |
|
Subcutis |
observed |
|
| C3H/BiDa | Eye - Harderian gland tumor - epithelial |
|
Eye - Harderian gland |
observed |
|
| C3H/BiDa | Eye - Lacrimal gland tumor |
|
Eye - Lacrimal gland |
3.1 - 37.5 |
|
| C3H/BiDa | Eye - Lacrimal gland tumor |
|
Eye - Lacrimal gland |
0 - 10.8 |
|
| C3H/BiDa | Eye - Lacrimal gland tumor - epithelial |
|
Eye - Lacrimal gland |
observed |
|
| C3H/BiDa | Heart tumor - mesenchymal |
|
Heart |
observed |
|
| C3H/BiDa | Kidney - Medulla tumor |
|
Kidney - Medulla |
21.9 |
|
| C3H/BiDa | Kidney - Medulla tumor |
|
Kidney - Medulla |
0 |
|
| C3H/BiDa | Kidney - Medulla tumor |
|
Kidney - Medulla |
13.0 |
|
| C3H/BiDa | Kidney - Medulla tumor |
|
Kidney - Medulla |
0 |
|
| C3H/BiDa | Kidney - Medulla tumor |
|
Kidney - Medulla |
0 |
|
| C3H/BiDa | Kidney - Medulla tumor |
|
Kidney - Medulla |
10.8 |
|
| C3H/BiDa | Kidney - Medulla tumor - mesenchymal |
|
Kidney - Medulla |
observed |
|
| C3H/BiDa | Kidney tumor |
|
Kidney |
0 - 18.8 |
|
| C3H/BiDa | Kidney tumor |
|
Kidney |
18.2 |
|
| C3H/BiDa | Larynx tumor - epithelial |
|
Larynx |
observed |
|
| C3H/BiDa | Liver neoplasm |
|
Liver |
observed |
|
| C3H/BiDa | Liver neoplasm | Liver |
observed |
||
| C3H/BiDa | Mammary gland adenoacanthoma |
|
Mammary gland |
observed |
|
| C3H/BiDa | Mammary gland adenocarcinoma - ductal |
|
Mammary gland |
observed |
|
| C3H/BiDa | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
observed |
|
| C3H/BiDa | Mammary gland tumor |
|
Mammary gland |
9.4 - 59.4 |
|
| C3H/BiDa | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C3H/BiDa | Mammary gland tumor |
|
Mammary gland |
43.5 |
|
| C3H/BiDa | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C3H/BiDa | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C3H/BiDa | Mammary gland tumor |
|
Mammary gland |
0 - 43.8 |
|
| C3H/BiDa | Mammary gland tumor |
|
Mammary gland |
27.3 |
|
| C3H/BiDa | Mammary gland tumor - epithelial |
|
Mammary gland |
observed |
|
| C3H/BiDa | Mesodermal cell/mesoblast myxosarcoma |
|
Subcutis |
observed |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Subcutis |
3.1 - 46.9 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Subcutis |
0 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Subcutis |
4.3 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Subcutis |
31.8 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Subcutis |
12.1 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Subcutis |
0 - 66.7 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Kidney |
43.8 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Kidney - Medulla |
65.6 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Kidney |
24.3 - 35.1 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Subcutis |
9.1 |
|
| C3H/BiDa | Mesodermal cell/mesoblast sarcoma |
|
Kidney - Medulla |
observed |
|
| C3H/BiDa | Nose - Nasal cavity - Nasal gland tumor - epithelial |
|
Nose - Nasal cavity - Nasal gland |
observed |
|
| C3H/BiDa | Nose - Nasal cavity - Olfactory epithelium tumor - epithelial |
|
Nose - Nasal cavity - Olfactory epithelium |
observed |
|
| C3H/BiDa | Pericyte hemangiopericytoma |
|
Subcutis |
observed |
|
| C3H/BiDa | Peritoneum tumor - mesenchymal |
|
Peritoneum |
observed |
|
| C3H/BiDa | Periurethral gland tumor |
|
Periurethral gland |
0 - 21.9 |
|
| C3H/BiDa | Periurethral gland tumor |
|
Periurethral gland |
0 |
|
| C3H/BiDa | Periurethral gland tumor |
|
Periurethral gland |
observed |
|
| C3H/BiDa | Periurethral gland tumor |
|
Periurethral gland |
0 |
|
| C3H/BiDa | Periurethral gland tumor |
|
Periurethral gland |
0 - 5.4 |
|
| C3H/BiDa | Periurethral gland tumor - epithelial |
|
Periurethral gland |
observed |
|
| C3H/BiDa | Prostate gland tumor |
|
Prostate gland |
0 - 6.2 |
|
| C3H/BiDa | Prostate gland tumor |
|
Prostate gland |
0 - 5.4 |
|
| C3H/BiDa | Prostate gland tumor - epithelial |
|
Prostate gland |
very low |
|
| C3H/BiDa | Prostate gland tumor - polypoid |
|
Prostate gland |
observed |
|
| C3H/BiDa | Salivary gland - Parotid adenoma - pleomorphic |
|
Salivary gland - Parotid |
observed |
|
| C3H/BiDa | Salivary gland - Parotid tumor |
|
Salivary gland - Parotid |
observed |
|
| C3H/BiDa | Salivary gland - Submandibular tumor - epithelial |
|
Salivary gland - Submandibular |
observed |
|
| C3H/BiDa | Salivary gland tumor |
|
Salivary gland |
12.5 - 84.4 |
|
| C3H/BiDa | Salivary gland tumor |
|
Salivary gland |
0 |
|
| C3H/BiDa | Salivary gland tumor |
|
Salivary gland |
78.3 |
|
| C3H/BiDa | Salivary gland tumor |
|
Salivary gland |
0 |
|
| C3H/BiDa | Salivary gland tumor |
|
Salivary gland |
0 |
|
| C3H/BiDa | Salivary gland tumor |
|
Salivary gland |
16.2 - 40.5 |
|
| C3H/BiDa | Salivary gland tumor |
|
Salivary gland |
27.3 |
|
| C3H/BiDa | Salivary gland tumor - epithelial |
|
Salivary gland |
observed |
|
| C3H/BiDa | Skin - Hair follicle tumor |
|
Skin - Hair follicle |
0 - 100 |
|
| C3H/BiDa | Skin - Hair follicle tumor |
|
Skin - Hair follicle |
0 |
|
| C3H/BiDa | Skin - Hair follicle tumor |
|
Skin - Hair follicle |
95.7 |
|
| C3H/BiDa | Skin - Hair follicle tumor |
|
Skin - Hair follicle |
0 |
|
| C3H/BiDa | Skin - Hair follicle tumor |
|
Skin - Hair follicle |
0 |
|
| C3H/BiDa | Skin - Hair follicle tumor |
|
Skin - Hair follicle |
2.7 - 93.8 |
|
| C3H/BiDa | Skin - Hair follicle tumor |
|
Skin - Hair follicle |
90.9 |
|
| C3H/BiDa | Skin - Hair follicle tumor - epithelial |
|
Skin - Hair follicle |
observed |
|
| C3H/BiDa | Skin epithelioma |
|
Thymus |
0 |
|
| C3H/BiDa | Skin epithelioma |
|
Thymus |
0 - 8.7 |
|
| C3H/BiDa | Skin epithelioma |
|
Thymus |
0 |
|
| C3H/BiDa | Skin epithelioma |
|
Thymus |
0 |
|
| C3H/BiDa | Skin epithelioma |
|
Thymus |
2.7 - 93.8 |
|
| C3H/BiDa | Skin epithelioma |
|
Thymus |
6.2 - 96.9 |
|
| C3H/BiDa | Skin epithelioma |
|
Thymus |
100 |
|
| C3H/BiDa | Skin gland - Sebaceous gland tumor - epithelial |
|
Skin gland - Sebaceous gland |
observed |
|
| C3H/BiDa | Skin gland - Sweat gland tumor - epithelial |
|
Skin gland - Sweat gland |
very low |
|
| C3H/BiDa | Thoracic cavity tumor - mesenchymal |
|
Thoracic cavity |
observed |
|
| C3H/BiDa | Thymus epithelioma |
|
Thymus |
90.6 |
|
| C3H/BiDa | Thymus tumor - epithelial |
|
Thymus |
observed |
|
| C3H/BiDa | Thyroid gland tumor |
|
Thyroid gland |
0 - 3.1 |
|
| C3H/BiDa | Thyroid gland tumor |
|
Thyroid gland |
0 |
|
| C3H/BiDa | Thyroid gland tumor |
|
Thyroid gland |
observed |
|
| C3H/BiDa | Thyroid gland tumor |
|
Thyroid gland |
0 |
|
| C3H/BiDa | Thyroid gland tumor |
|
Thyroid gland |
0 - 5.4 |
|
| C3H/BiDa | Thyroid gland tumor - epithelial |
|
Thyroid gland |
very low |
|
| C3H/BiDa | Tooth - Tooth enamel organ tumor - epithelial |
|
Tooth - Tooth enamel organ |
observed |
|
| C3H/BiDa | Tooth ameloblastoma |
|
Tooth |
observed |
|
| C3H/BiDa | Tooth ameloblastoma |
|
Tooth |
0 |
|
| C3H/BiDa | Tooth ameloblastoma |
|
Tooth |
observed |
|
| C3H/BiDa | Tooth ameloblastoma |
|
Tooth |
0 |
|
| C3H/BiDa | Tooth tumor - epithelial |
|
Tooth |
9.4 |
|
| C3H/BiDa | Tooth tumor - epithelial |
|
Tooth |
2.7 |
|
| C3H/BiDa | (Unspecified organ) tumor |
|
(Unspecified organ) |
100 |
|
| C3H/BiDa | (Unspecified organ) tumor |
|
(Unspecified organ) |
40 |
|
| C3H/BiDa | (Unspecified organ) tumor |
|
(Unspecified organ) |
100 |
|
| C3H/BiDa | (Unspecified organ) tumor |
|
(Unspecified organ) |
31.8 |
|
| C3H/BiDa | (Unspecified organ) tumor |
|
(Unspecified organ) |
12.1 |
|
| C3H/BiDa | (Unspecified organ) tumor |
|
(Unspecified organ) |
94.7 - 100 |
|
| C3H/BiDa | (Unspecified organ) tumor |
|
(Unspecified organ) |
100 |