Reference SummaryAngel JM, J Natl Cancer Inst 1989 Nov 1;81(21):1652-5

Title

 Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7.

Authors

 Angel JM; Morizot DC; Richie ER

Journal

 J Natl Cancer Inst

Volume

 81

Issue

 21

Year

 1989

Pages

 1652-5

Abstract

 Treatment of young AKR/J mice with N-methyl-N-nitrosourea (MNU) results in the induction of a high incidence of thymic lymphomas occurring between 4 and 6 months of age. The tumor incidence is higher and the latency period is shorter than that observed in other MNU-treated mouse strains. Analysis of tumor incidence in crosses of AKR/J with C57L/J mice indicates that several genes influence the incidence and latency of MNU-induced thymic lymphomas. One of these genes appears to be tightly linked to the albino locus of chromosome 7.

Links

 J:10061 – MGI References
2552132 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
AKR/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0 - 78
AKR/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
 Thymus

84
C57L/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0
C57L/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
 Thymus

0 - 39
(AKR/J x C57L/J)F1 Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0
(AKR/J x C57L/J)F1 Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
 Thymus

42
(AKR/J x C57L/J)F2 Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0
(AKR/J x C57L/J)F2 Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
 Thymus

24