PDX Model DetailsTM00098

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00098 (BR1126F)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IA / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

 Wang, M; et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. 2018 FASEB 2018 Mar;32(3):1537-1549.  10.1096/fj.201700740R
Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
64
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample BR1126F030P0 from passage P0 has a TMB score of 12.12
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:BR1126F030P0 from passage P0     Score:MSI-S

Gene Fusion
Fusion Genes
Sample BR1126F030P0 has fusion gene NFIX--MAST1

Model Characterization

Histology

 Summary:
P1 is AE1/AE3 positive,AR, ER, PR, ERBB2 (Her2) negative. P0, P1 pathology consistent with high grade breast carcinoma. P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F028 for PDX model TM00098 stained for H&E.
P1 tumor F030 ID362 for PDX model TM00098 stained for H&E.

P1 tumor F030 ID362 for PDX model TM00098 stained for AE1AE3. Staining was positive.
P1 tumor F030 ID362 for PDX model TM00098 stained for AR. Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for ER. Staining was negative.
P1 tumor F030 ID362 for PDX model TM00098 stained for ERBB2 (HER2). Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for PR. Staining was negative.
P2 tumor F030 ID014 for PDX model TM00098 stained for H&E.

P2 tumor F030 ID014 for PDX model TM00098 stained for AE1AE3. Staining was positive.
P2 tumor F030 ID014 for PDX model TM00098 stained for Ki67. Staining was positive.

P2 tumor F030 ID014 for PDX model TM00098 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data