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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Strain Search Results  
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221 matching items displayed.
Strain Name Strain Type Strain Notes
129-Trp53tm1Tyj/J targeted mutation (knockout) Heterozygous mice
129/Sv-Hoxa5tm1Rob Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was "129/Sv" (substrains unspecified but included at least 129S/SvEv and 129S2/SvPas).
129/Sv-Hoxa5tm1Rob/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was "129/Sv" (substrains unspecified but included at least 129S/SvEv and 129S2/SvPas).
129/Sv-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was "129/Sv" (substrains unspecified but included at least 129S2/SvPas and likely 129S/SvEv).
129;B6-Apc Min/+ Trp53tm1Tyj/+ chemically induced mutation &
targeted mutation (knockout)
Heterozygous Min, Trp53 mice on a mixed 129, B6 background with contribution from C57BL/6J, 129S2/SvPas and 129P2/OlaHsd.
129;B6-Apc Min/+ Trp53tm1Tyj/+ Zfp148Gt(XB878)Byg/+ chemically induced mutation &
gene trapped &
targeted mutation (knockout)
Heterozygous Min, Trp53, Zfp148 mice on a mixed 129, B6 background with contribution from C57BL/6J, 129S2/SvPas and 129P2/OlaHsd.
129;B6-Ercc8tm1Jhjh Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice heterozygous for Trp53tm1Tyj and homozygous for Ercc8tm1Jhjh. Background was stated to be ~70% 129 (including 129S2/SvPas) and 30% C57BL/6. Some contribution from CBA may also be present.
129;B6-Trp53tm1Tyj/+ Xpatm1Tnka targeted mutation (knockout) Compound mutant mice heterozygous for Trp53tm1Tyj and homozygous for Xpatm1Tnka. Background was stated to be ~70% 129/Sv (including 129S2/SvPas) and 30% C57BL/6. Some contribution from CBA may also be present.
129;B6-Trp53tm1Tyj/+ Xpctm1Ecf targeted mutation (knockout) Compound mutant mice heterozygous for Trp53tm1Tyj and homozygous for Xpctm1Ecf. Background was stated to be ~70% 129 (including 129S2/SvPas) and 30% C57BL/6.
129S-Krastm2Tyj/+ Trp53tm1Tyj/+ targeted mutation (knock-in) &
targeted mutation (knockout)
Double heterozygotes. The genetic background of these mice was stated to be greater than 90% 129/Sv. The other strains involved in this background were not specified.
129S-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The gentic background of these mice was stated to be 129S1/SvImJ. It also included some 129S2/SvPas.
129S-Trp53tm1Tyj/+ Trp73tm1Fmc targeted mutation (knockout) Compound mutant mice. The gentic background of these mice was stated to be 129S1/SvImJ. It also included some 129S2/SvPas and some 129S4/SvJae.
129S1/SvImJ-Rb1tm1Tyj/+ Trp53tm1Tyj/+ targeted mutation (knockout) Mice are heterozygous for both the Rb1tm1Tyj and the Trp53tm1Tyj alleles.
129S4.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + congenic &
targeted mutation (knockout)
Mice heterozygous for Nf1 and Trp53 mutations on 129S4.129S2 backgrounds were crossed to make "trans" mice (alleles on opposite chromosomes). Mice were crossed to 129S4/SvJae mice to produce "cis" mice (alleles on the same chromosome).
B10;B6-Dmdmdx Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53, female homozygous, male hemizygous Dmd mice were generated by crossing B6.129S2-Trp53>tm1Tyj/J (stock# 002101) and C57BL/10ScSn-Dmdmdx/J (stock# 001801) strains.
B10;B6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice were generated by crossing B6.129S2-Trp53>tm1Tyj/J (stock# 002101) and C57BL/10ScSn-Dmdmdx/J (stock# 001801) strains.
B6.129-Apctm1Rak/+ Trp53tm1Tyj/+ congenic &
targeted mutation (knockout)
Compound mutant mice. These mice are the product of an intercross between strains on a predominantly C57BL/6JIco background where the mice were subsequently backcrossed to C57BL/6JIco.
B6.129-Trp53tm1Tyj/+ Xpatm1Hvs congenic &
targeted mutation (knockout)
Mice were heterozygous for the Trp53 mutation and homozygous for the Xpa mutation. The genetic background of these mice is backcrossed C57BL/6 (most likely C57BL/6J).
B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + congenic &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj were crossed with Trp53tm1Tyj heterozygotes to generate mice carrying both mutations on the same copy of chromosome 11 ("cis"). These "NPcis" mice were backcrossed to C57BL/6J.
B6.129S2-Trp53tm1Tyj/J congenic &
targeted mutation (knockout)
Heterozygous mice
B6;129-Cdkn2atm1Cjs Mdm2tm1Glo/+ Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was a mixture of C57BL/6 (64%) and 129/Sv (36%). The "129/Sv" was a combination of at least 129S2/SvPas, 129S7/SvEvBrd-Hprt+, and 129X1/SvJ.
B6;129-Cdkn2atm1Cjs Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was a mixture of C57BL/6 (64%) and 129/Sv (36%). The "129/Sv" was a combination of at least 129S2/SvPas, 129S7/SvEvBrd-Hprt+, and 129X1/SvJ.
B6;129-Cdkn2atm1Cjs/+ Mdm2tm1Glo/+ Trp53tm1Tyj/+ targeted mutation (knockout) Triple heterozygous mice. The genetic background of these mice was a mixture of C57BL/6 (64%) and 129/Sv (36%). The "129/Sv" was a combination of at least 129S2/SvPas, 129S7/SvEvBrd-Hprt+, and 129X1/SvJ.
B6;129-Cdkn2atm1Cjs/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was a mixture of C57BL/6 (64%) and 129/Sv (36%). The "129/Sv" was a combination of at least 129S2/SvPas, 129S7/SvEvBrd-Hprt+, and 129X1/SvJ.
B6;129-Fn1tm1Hyn/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was a mixture of C57BL/6 x 129/Sv (substrain not specified but included at least 129S2/SvPas).
B6;129-Hace1tm1Pngr Trp53tm1Tyj/+ targeted mutation (knockout) These mice were homozygous for the Hace1 and heterozygous for the Trp53 mutant alleles. The genetic background of these mice was a mixture of C57BL/6, 129P2/OlaHsd, and 129S2/SvPas.
B6;129-Hace1tm1Pngr/+ Trp53tm1Tyj/+ targeted mutation (knockout) These mice were heterozygous for both mutant alleles. The genetic background of these mice was a mixture of C57BL/6, 129P2/OlaHsd, and 129S2/SvPas.
B6;129-Itga5tm1Hyn/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was a mixture of C57BL/6 x 129/Sv (substrain not specified but included at least 129S2/SvPas).
B6;129-Nf1tm1Fcr +/+ Trp53tm1Tyj targeted mutation (knockout) Mice heterozygous for gene-targeted mutant alleles of Nf1 and Trp53 on opposite chromosomes 11 ("trans" heterozygotes). The genetic background was a mix of C57BL/6 and 129/Sv (a mixture of 129S2/SvPas, 129S4/SvJae, and 129S6/SvEv).
B6;129-Nf1tm1Fcr Trp53tm1Tyj/+ + targeted mutation (knockout) Mice heterozygous for gene-targeted mutant alleles of Nf1 and Trp53 on the same chromosome 11 ("cis" heterozygotes). The genetic background was a mix of C57BL/6 and 129/Sv (a mixture of 129S2/SvPas, 129S4/SvJae, and 129S6/SvEv).
B6;129-Ptentm1Ppp/+ Trp53tm1Tyj/+ targeted mutation (knockout) Mice heterozygous for both Trp53 and Pten. Background includes contributions from C57BL/6, 129S1/SvImJ, 129S2/SvPas, and possibly other substrains of 129/Sv.
B6;129-Rpa1tm1Wed +/+ Trp53tm1Tyj targeted mutation (knock-in) &
targeted mutation (knockout)
Mutant alleles carried on opposite copies of Chr. 11 ("trans"). The genetic background of these mice was predominantly a mixture of C57BL/6 and 129S4/SvJae. It also included some 129S2/SvPas and likely some unspecified 129/Sv and some SJL.
B6;129-Rpa1tm1Wed Trp53tm1Tyj/+ + targeted mutation (knock-in) &
targeted mutation (knockout)
Mutant alleles carried on the same copy of Chr. 11 ("cis"). The genetic background of these mice was predominantly a mixture of C57BL/6 and 129S4/SvJae. It also included some 129S2/SvPas and likely some unspecified 129/Sv and some SJL.
B6;129-Rpl27aSfa/+ Trp53tm1Tyj/+ chemically induced mutation &
targeted mutation (knockout)
Heterozygous mice were on a mixed C57BL/6J and 129S6/SvEvTac genetic background with possible contribution from 129S2/SvPas.
B6;129-Tg(IghMyc)22Bri Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Heterozygous mice carrying the transgene on a 75% C57BL/6, 25% 129/Sv background with possible contributions from SJL and 129S2/SvPas.
B6;129-Thbs1tm1Hyn Trp53tm1Tyj/+ targeted mutation (knockout) Mice were homozygous for the Thbs1 and heterozygous for the Trp53 mutant alleles. The genetic background of these mice was a mixture of C57BL/6J and 129/Sv (at least 129S2/SvPas from the ES cells and possibly some other 129/Sv substrain).
B6;129-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice is a mixture of C57BL/6J and 129/Sv (at least 129S2/SvPas from the ES cells and possibly some other 129/Sv substrain).
B6;129-Trp53tm1Tyj/+ targeted mutation (knockout) Mice heterozygous for Trp53 knockout. Mice were referred to as (C57BL/6 X 129)F1. Background included contributions from C57BL/6, 129S2/SvPas, and possibly some other substrain of 129/Sv.
B6;129-Trp53tm1Tyj/+ targeted mutation (knockout) Mice heterozygous for Trp53 knockout, Pten wild type. Background includes contributions from C57BL/6, 129S1/SvImJ, 129S2/SvPas, and possibly other substrains of 129/Sv.
B6;129-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygote mice. Background is a mix of C57BL/6 and 129 (including 129S2/SvPas and 129P2/OlaHsd substrains).
B6;129-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice were on a mixed C57BL/6J and 129S6/SvEvTac genetic background with possible contribution from 129S2/SvPas.
B6;129-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was a mixture of C57BL/6 x 129/Sv (substrain not specified but included at least 129S2/SvPas).
B6;129-Trp53tm1Tyj/+ Xpatm1Hvs targeted mutation (knockout) Compound mutant mice, heterozygous for Trp53tm1Tyj and homozygous for Xpatm1Hvs. Background is a mix of C57BL/6 and 129 (including 129S2/SvPas and 129P2/OlaHsd substrains).
B6;129S-ApcMin/+ Trp53tm1Tyj/+ chemically induced mutation &
targeted mutation (knockout)
Mice were heterozygous for the ApcMin mutation and heterozygous for the Trp53tm1Tyj mutation. The genetic background of these mice is a mixture of C57BL/6J, 129S2/SvPas, and 129S4/SvJae.
B6;129S-Atrtm1Bal/+ Krastm4Tyj/+ Ndor1Tg(UBC-cre/ERT2)1Ejb/? Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout) &
transgenic
Mice were heterozygous for the knock-in and both knock-out alleles and carried the transgene. The genetic background of these mice was a mixture of C57BL/6 and 129S (including at least 129S/SvEv, 129S4/SvJae, 129S2/SvPas, and 129S/Sv).
B6;129S-Dph1tm2Bhr Trp53tm1Tyj/+ + targeted mutation (knockout) Double heterozygotes. Alleles may have been in "cis" or in "trans". The genetic background of these mice was a mixture of predominantly C57BL/6 and "129/SvEv" (substrain not specified), and also contained some 129S4/SvJae and some 129S2/SvPas.
B6;129S-Krastm4Tyj/+ Ndor1Tg(UBC-cre/ERT2)1Ejb/? Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout) &
transgenic
Mice were heterozygous for the knock-in and knock-out alleles and carried the transgene. The genetic background of these mice was a mixture of C57BL/6 and 129S (including at least 129S/SvEv, 129S4/SvJae, and 129S2/SvPas).
B6;129S-Mtbptm1Glo/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was a mixture of C57BL/6J and 129S (including 129S2/SvPas and 129S7/SvEvBrd-Hprt1+).
B6;129S-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of this strain is a mixture of C57BL/6 and 129S/Sv (a mixture of 129S2/SvPas and 129S4/SvJae).
B6;129S-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was a mixture of predominantly C57BL/6 and "129/SvEv" (substrain not specified), and also carried some 129S2/SvPas.
B6;129S-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was a mixture of C57BL/6 and 129S (129S2/SvPas and 129S4/SvJae).
B6;129S-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was a mixture of C57BL/6J and 129S (including 129S2/SvPas and 129S7/SvEvBrd-Hprt1+).
B6;129S-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was predominantly a mixture of C57BL/6 and 129S4/SvJae. It also included some 129S2/SvPas.
B6;129S-Trp53tm1Tyj/+ Trp63tm1Fmc/+ targeted mutation (knockout) These mice were heterozygous for both mutant alleles. The genetic background of these mice was a mixture of C57BL/6 and 129S (129S2/SvPas and 129S4/SvJae).
B6;129S-Trp53tm1Tyj/+ Trp73tm1Fmc/+ targeted mutation (knockout) These mice were heterozygous for both mutant alleles. The genetic background of these mice was a mixture of C57BL/6 and 129S (129S2/SvPas and 129S4/SvJae).
B6;129S2-Nf1tm1Tyj +/+ Trp53tm1Tyj targeted mutation (knockout) Mice heterozygous for targeted mutations of Trp53 and Nf1 on opposite chromosomes 11 ("trans"). The genetic background of these mice is a mixture of C57BL/6 and 129S2/SvPas.
B6;129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + targeted mutation (knockout) Mice heterozygous for targeted mutations of Trp53 and Nf1 on the same chromosome 11 ("cis"). The genetic background of these mice is a mixture of C57BL/6 and 129S2/SvPas.
B6;129S2-Rb1tm1Tyj/+ Trp53tm1Tyj/+ targeted mutation (knockout) Mice are heterozygous for Rb1tm1Tyj and heterozygous for Trp53tm1Tyj. This strain was generated by crossing 2 targeted mutant strains. The genetic background of this strain is a mixture of C57BL/6 and 129S2/SvPas.
B6;129S2-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of this strain is a mixture of C57BL/6 and 129S2/SvPas.
B6;129S4-Hic1tm1Sbb +/+ Trp53tm1Tyj targeted mutation (knockout) The genetic background of these mice was a mix of C57BL/6 and 129S4/SvJae. MIce were heterozygous for the Hic1tm1Sbb and Trp53tm1Tyj mutations. Mutations were carried in "trans".
B6;129S4-Hic1tm1Sbb Trp53tm1Tyj/+ + targeted mutation (knockout) The genetic background of these mice was a mix of C57BL/6 and 129S4/SvJae. MIce were heterozygous for the Hic1tm1Sbb and Trp53tm1Tyj mutations. Mutations were carried in "cis".
B6;129S4-Trp53tm1Tyj/+ targeted mutation (knockout) The genetic background of these mice was a mix of C57BL/6 and 129S4/SvJae. MIce were heterozygous for the Trp53tm1Tyj mutation.
B6;129S6-Krastm1Dsa/+ Tg(Pdx1-flpo)#Dsa Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout) &
transgenic
Heterozygous Kras, Trp53 mice also carrying the transgene on a mixed C57BL/6, 129S6/SvEv background with contribution from 129S6/SvEvTac and 129S2/SvPas from the original ES cells.
B6;C-Brca2tm1Kamc Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was approximately 50% C57BL/6 and 50% BALB/c with some amount of 129P2/OlaHsd and 129S2/SvPas.
B6;C-Brca2tm1Kamc/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was approximately 50% C57BL/6 and 50% BALB/c with some amount of 129P2/OlaHsd and 129S2/SvPas.
B6;C-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was approximately 50% C57BL/6 and 50% BALB/c with some amount of 129P2/OlaHsd and 129S2/SvPas.
B6D2-Tg(WAPT121)66Tvd Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. The genetic background of these mice was given as B6D2F1. It also contained some 129S2/SvPas and possibly some other strain(s).
BALB/c-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was predominantly BALB/c (via intercrossing of congenic strains) and likely included some amount of 129S2/SvPas and possibly some 129S6/SvEvTac and/or C57BL/6J.
BALB/c-Trp53tm1Tyj/+ Trp53bp2tm1Xlu targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was predominantly BALB/c (via intercrossing of congenic strains) and likely included some amount of 129S2/SvPas, 129S6/SvEvTac, and possibly some C57BL/6J.
BALB/c-Trp53tm1Tyj/+ Trp53bp2tm1Xlu/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was predominantly BALB/c (via intercrossing of congenic strains) and likely included some amount of 129S2/SvPas, 129S6/SvEvTac, and possibly some C57BL/6J.
BALB/cJ-Brca1tm1Bhk/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was predominantly BALB/cJ. It also contained some 129P2/OlaHsd and some 129S2/SvPas and possibly some other strain(s).
BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. This cohort was generated by crossing congenic BALB/cJ mice carrying each of the mutations. Genetic background also contained some 129S1/Sv-Oca2+ Tyr+ Kitl+ & some 129S2/SvPas.
BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. This cohort was generated by crossing congenic BALB/cJ mice carrying each of the mutations. The genetic background also contained some 129S2/SvPas.
BALB/cJ-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was predominantly BALB/cJ. It also contained some 129S2/SvPas and possibly some other strain(s).
C.129S2-Trp53tm1Tyj/+ congenic &
targeted mutation (knockout)
Heterozygous mice. The genetic background of these mice is predominantly BALB/cMed.
C.129S2-Trp53tm1Tyj/+ congenic &
targeted mutation (knockout)
Heterozygous mice. The mutation had been backcrossed onto a BALB/cJ genetic background. The mutation was generated in a 129S2/SvPas genetic background.
C3Ou.129S2(B6)-Trp53tm1Tyj/J congenic &
targeted mutation (knockout)
Heterozygous mice. Mice carrying this mutation on a mixed 129S2 x C57BL/6 genetic background were backcrossed at least 5 times to C3H/HeOuJ.
C57BL/6-Apctm1Tno/+ Egr1tm1Jmi/+ Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout)
Heterozygous Apctm1Tno, Egr1tm1Jmi, Trp53tm1Brd mice on a C57BL/6 background with possible contributions from 129S2/SvPas, 129S4/SvJae, CBA, and an unspecified 129 substrain.
C57BL/6-Apctm1Tno/+ Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout)
Heterozygous Apctm1Tno, Trp53tm1Brd mice on a C57BL/6 background with possible contributions from 129S2/SvPas, 129S4/SvJae, CBA, and an unspecified 129 substrain.
C57BL/6-Atf3tm1Dron Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was predominantly C57BL/6 including at least some C57BL/6J. It also included some 129X1/SvJ and some 129S2/SvPas.
C57BL/6-Bcl2l11tm1.1Ast Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53, homozygous Bcl2l11 mutant mice on a predominantly C57BL/6 background with possible contribution from 129S2/SvPas, 129S1/Sv, and/or other strain(s).
C57BL/6-Bcl2l11tm1.1Ast/+ Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53, Bcl2l11 mutant mice on a predominantly C57BL/6 background with possible contribution from 129S2/SvPas, 129S1/Sv, and/or other strain(s).
C57BL/6-Bmftm1.1Ast Trp53tm1Tyj/+ targeted mutation (knockout) Homozygous Bmf, heterozygous Trp53 mutant mice on a predominantly C57BL/6 background with possible contribution of 129S2/SvPas and/or some other strain(s).
C57BL/6-Bmftm1.1Ast/+ Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53, Bmf mutant mice on a predominantly C57BL/6 background with possible contribution of 129S2/SvPas and/or some other strain(s).
C57BL/6-Cdkn1atm1Tyj Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. These mice were generated by crossing targeted mutant mice on a C57BL/6 genetic background.
C57BL/6-Cul9tm1.2Yxi Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The strains crossed to generate this cohort had been backcrossed to C57BL/6 prior to that cross. The genetic background may also include some 129S2/SvPas, 129P2/OlaHsd, and/or FVB/N.
C57BL/6-Cul9tm1.2Yxi/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The strains crossed to generate this cohort had been backcrossed to C57BL/6 prior to that cross. The genetic background may also include some 129S2/SvPas, 129P2/OlaHsd, and/or FVB/N.
C57BL/6-Egr1tm1Jmi/+ Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53tm1Brd, Egr1tm1Jmi mice on a C57BL/6 background with possible contributions from 129S2/SvPas and an unspecified 129 substrain.
C57BL/6-Hsf4tm1Miv Trp53tm1Tyj/+ targeted mutation (knockout) &
targeted mutation (other)
Compound mutant mice. The genetic background of these mice was predominantly C57BL/6, generated by crossing strains each on that backgound. There was likely some contribution from 129S2/SvPas.
C57BL/6-Kat6atm2.2Avo/+ Tg(IghMyc)22Bri Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Heterozygous Trp53tm1Tyj, Kat6atm2.2Avo mice also carrying the Tg(IghMyc)22Bri transgene on a C57BL/6 background with possible contribution from 129S2/SvPas, C57BL, and/or SJL.
C57BL/6-Msh2tm1Rak Trp53tm1Tyj/+ targeted mutation (knockout) Homozygous Msh2tm1Rak, heterozygous Trp53tm1Tyj mice on a C57BL/6 background with possible contribution from129S2/SvPas, 129/Sv, C57BL/6J, SJL, and/or 129P2/OlaHsd.
C57BL/6-Msh3tm1Rak Trp53tm1Tyj/+ targeted mutation (knockout) Homozygous Msh3tm1Rak, heterozygous Trp53tm1Tyj mice on a C57BL/6 background with possible contribution from129S2/SvPas, 129/Sv, C57BL/6J, SJL, and/or 129P2/OlaHsd.
C57BL/6-Qkqk-v Trp53tm1Tyj/+ spontaneous mutation &
targeted mutation (knockout)
Heterozygous Trp53, homozygous Qk mice on a C57BL/6 background with possible contribution from DBA/2J and 129S2/SvPas.
C57BL/6-Rbm38tm1.1Xch Trp53tm1Tyj/+ targeted mutation (knockout) Homozygous Rbm38, heterozygous Trp53 mice on a background that is at least 75% C57BL/6 with contribution from FVB/N from the cre deleter strain use and 129S2/SvPas from the original ES cells.. The "EIIa-cre" allele may still be present.
C57BL/6-Sphk1tm1Rlp Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was predominantly C57BL/6. These mice were generated by crossing two knockout strains.
C57BL/6-Sphk1tm1Rlp/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background of these mice was predominantly C57BL/6. These mice were generated by crossing two knockout strains.
C57BL/6-Tg(IghMyc)22Bri Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Heterozygous Trp53tm1Tyj mice carrying the Tg(IghMyc)22Bri transgene on a C57BL/6 background with possible contribution from 129S2/SvPas, C57BL, and/or SJL.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. These mice are the product of an intercross between strains on a predominantly C57BL/6 background. The genetic background also contained some 129S2/SvPas and possibly some 129S7/SvEvBrd-Hprt+.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was predominantly C57BL/6 and also included some 129S4/SvJae, some 129S2/SvPas and possibly another unspecified strain(s).
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The strains crossed to generate this cohort had been backcrossed to C57BL/6 prior to that cross. The genetic background may also include some 129S2/SvPas, 129P2/OlaHsd, and/or FVB/N.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was predominantly C57BL/6. These mice were generated by crossing two knockout strains.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. These mice were generated by crossing targeted mutant mice on a C57BL/6 genetic background.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice on a C57BL/6 background.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53 mice on a C57BL/6 background with possible contribution from 129S2/SvPas.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was predominantly C57BL/6, generated by crossing strains each on that backgound. There was likely some contribution from 129S2/SvPas.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53tm1Brd mice on a C57BL/6 background with possible contributions from 129S2/SvPas and an unspecified 129 substrain.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53tm1Tyj mice on a C57BL/6 background with possible contribution from129S2/SvPas, 129/Sv, C57BL/6J, SJL, and/or 129P2/OlaHsd.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53 mutant mice on a predominantly C57BL/6 background with possible contribution of 129S2/SvPas and/or other strain(s).
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53 mice on a C57BL/6 background with contribution from 129S2/SvPas from the original ES cells.
C57BL/6-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was predominantly C57BL/6 including at least some C57BL/6J. It also included some 129S2/SvPas and possibly some 129X1/SvJ.
C57BL/6-Trp53tm1Tyj/+ Trp63tm1.1Elrf targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was predominantly C57BL/6 and also included some 129S4/SvJae, some 129S2/SvPas and possibly another unspecified strain(s).
C57BL/6-Trp53tm1Tyj/+ Trp63tm1.1Elrf/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was predominantly C57BL/6 and also included some 129S4/SvJae, some 129S2/SvPas and possibly another unspecified strain(s).
C57BL/6-Trp53tm1Tyj/+ Uimc1tm1.2Amj targeted mutation (knockout) Heterozygous Trp53, homozygous Uimc1 mice on a C57BL/6 background with possible contribution from BALB/cJ and 129S2/SvPas. Mice may also contain the Tg(CMV-cre)1Cgn transgene.
C57BL/6J-Espl1Gt(XL058)Byg/+ Trp53tm1Tyj/+ gene trapped &
targeted mutation (knockout)
Double heterozygous mice on a C57BL/6J background with possible contributions from 129P2/OlaHsd and 129S2/SvPas.
C57BL/6J-Fancctm1Mab Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53tm1Tyj, homozygous Fancctm1Mab mice on a C57BL/6J background with possible contributions from 129X1/SvJ, 129S1/Sv, and 129S2/SvPas.
C57BL/6J-Faslgld Trp53tm1Tyj/+ spontaneous mutation &
targeted mutation (knockout)
Compound mutant mice. These mice were generated by crossing two mutant strains (and, subsequently, their progeny) each congenic for a substrain of C57BL/6 (C57BL/6J and C57BL/6JSmn).
C57BL/6J-Tg(Alb1HBV)44Bri/J Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
These mice are the product of an intercross between strains on a predominantly C57BL/6J background.
C57BL/6J-Tg(GFAP-PDGFB)C8Mais Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
These mice carried the transgene and were heterozygous for the Trp53 KO allele. They were generated by crossing two strains, each fully on a C57BL/6J genetic background. The background may include some amount of 129S2/SvPas.
C57BL/6J-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53tm1Tyj mice on a C57BL/6J background with possible contributions from 129X1/SvJ, 129S1/Sv, and/or 129S2/SvPas.
C57BL/6J-Trp53tm1Tyj/+ targeted mutation (knockout) Hemizygous mice. These mice were generated by crossing two mutant strains (and, subsequently, their progeny) each congenic for a substrain of C57BL/6 (C57BL/6J and C57BL/6JSmn).
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was predominantly C57BL/6J. This cohort was generated by crossing 2 mutant strains each congenic for C57BL/6J.
CE129F1-Trp53tm1Tyj/+ hybrid &
targeted mutation (knockout)
Heterozygous mice. Female CE/J mice were crossed to male 129-Trp53tm1Tyj/J homozygous knockout mice.
CE129F2-Trp53tm1Tyj/+ hybrid &
targeted mutation (knockout)
Heterozygous mice. These mice were generated by crossing CE129F1-Trp53tm1Tyj/+ heterozygous mice (CE/J background female x 129 background male).
FVB.Cg-Tg(MMTVneu)202Mul Trp53tm1Tyj/+ congenic &
targeted mutation (knockout) &
transgenic
These mice were carrying the Tg(MMTVneu)202Mul transgene and were heterozygous for the Trp53tm1Tyj allele. They had been backcrossed to FVB/NJ.
FVB/N-Cdkn2atm2.1Rdp Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53tm1Tyj, homozygous Cdkn2atm2.1Rdp mice on an ~87.5% FVB/N background with contributions from at least 129S2/SvPas and 129S6/SvEvTac.
FVB/N-Cdkn2atm2.1Rdp/+ Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice on an ~87.5% FVB/N background with contributions from at least 129S2/SvPas and 129S6/SvEvTac
FVB/N-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice on an ~87.5% FVB/N background with contributions from at least 129S2/SvPas and 129S6/SvEvTac
FVB;129S-Tg(C3-1-TAg)cJeg Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice are hemizygous for the transgene and heterozygous for the Trp53tm1Tyj allele. The genetic background of these mice is a mixture of FVB/N and 129S (a mixture of 129 substrains including 129S2/SvPas and probably 129S4/SvJae).
FVB;129S2-Tg(Scgb1a1-rtTA)1Jaw Tg(tetO-Kras2)12Hev Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Heterozygous mutant mice carrying two transgenes on a genetic background that was a mixture of at least FVB/N and 129S2/SvPas.
STOCK Acdacd Trp53tm1Tyj/+ spontaneous mutation &
targeted mutation (knockout)
Compound mutant mice. This STOCK genetic background is a mixture of C57BL/6J, DW/J, CAST/Ei, and 129S2/SvPas.
STOCK Atmtm1Fwa Terc?/Terc+ Trp53tm1Tyj/Trp53? targeted mutation (knockout) Compound mutant mice, either heterozygous or wild-type for Terc (G0). This STOCK genetic background was predominantly C57BL/6 and 129/Sv (substrain not specified) and also contained SJL, 129S4/SvJae, and 129S2/SvPas.
STOCK Atmtm1Fwa Terctm1Rdp Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. This STOCK genetic background was predominantly C57BL/6 and 129/Sv (substrain not specified) and also contained SJL, 129S4/SvJae, and 129S2/SvPas.
STOCK Atmtm1Fwa Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. This STOCK genetic background was predominantly C57BL/6 and 129/Sv (substrain not specified) and also contained SJL, 129S4/SvJae, and 129S2/SvPas.
STOCK Brca1tm2Arge Trp53tm1Tyj/+ targeted mutation (knockout) Mice homozygous for a targeted mutation of Brca1 and heterozygous for a targeted mutation of Trp53. The genetic background was a mixture of "129/Sv", C57BL/6J, and MF1 (outbred).
STOCK Brca2tm1Brn Ptch1tm1Mps/+ Tg(Nes-cre)1Kln Trp53tm1Tyj/+ targeted mutation (conditional) &
transgenic
Homozygous Brca2tm1Brn, heterozygous Ptch1tm1Mps & Trp53tm1Tyj & transgenic mice. The genetic background contained 129P2/OlaHsd, 129X1/SvJ, 129S1/Sv, 129S2/SvPas, C57BL/6, & SJL.
STOCK Brca2tm1Brn Tg(Nes-cre)1Kln Trp53tm1Tyj/+ targeted mutation (conditional) &
transgenic
Mice were homozygous for Brca2tm1Brn, heterozygous for Trp53tm1Tyj, and carried the Tg(Nes-cre)1Kln transgene. The genetic background contained contributions from 129P2/OlaHsd, 129S2/SvPas, C57BL/6, and SJL.
STOCK Cdkn2atm1Rdp/+ Trp53tm1Tyj/+ targeted mutation (knockout) Mice were heterozygous for both the Cdkn2atm1Rdp and the Trp53tm1Tyj alleles. This STOCK genetic background was a mixture predominantly of C57BL/6 and CD-1 and also included 129/Sv, 129S2/SvPas, and SJL.
STOCK Ets2tm5.2Rgo/+ Nf1tm1Tyj/+ Trp53tm1Tyj/+ Ts(1716)65Dn radiation induced mutation &
targeted mutation (knockout)
Triple heterozygous mice carrying a trisomy mutation. This STOCK genetic background included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
STOCK Lig4tm1Pmc Tg(Nes-cre)1Kln Trp53tm1Tyj/+ targeted mutation (conditional) &
transgenic
Mice homozygous for Lig4tm1Pmc, heterozygous for Trp53tm1Tyj, and carried the Tg(Nes-cre)1Kln transgene. The genetic background contained contributions from 129S1/Sv, 129S2/SvPas, C57BL/6, and SJL.
STOCK Lig4tm1Pmc Tg(Nes-cre)1Kln Trp53tm1Tyj/+ Xccr2tm2Pmc targeted mutation (conditional) &
transgenic
Mice were homozygous for Lig4tm1Pmc and Xccr2tm2Pmc, heterozygous for Trp53tm1Tyj, and carried the Tg(Nes-cre)1Kln transgene. Genetic background contained 129S1/Sv, 129S2/SvPas, C57BL/6, and SJL.
STOCK Nf1tm1Par Tg(GFAP-cre)25Mes Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout) &
transgenic
Compound mutant mice. This STOCK genetic background was a mixture of C57BL/6 (~49.5%), 129X1/SvJ ~(49.5%), and FVB (~1%). It also contained some amount of 129S1/Sv and 129S2/SvPas.
STOCK Nf1tm1Tyj/+ Trp53tm1Tyj/+ Ts(1716)65Dn radiation induced mutation &
targeted mutation (knockout)
Double heterozygous mice carrying a trisomy mutation. This STOCK genetic background included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
STOCK Prkar1atm1.1Lsk/+ Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. This STOCK genetic background was a mixture of CD-1, C57BL/6, 129X1/SvJ, 129S1/Sv, and 129S2/SvPas.
STOCK Ptch1tm1Mps/+ Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice heterozygous for both Ptch1tm1Mps and Trp53tm1Tyj. Background included a mix of C57BL/6, CD1, 129S2/SvPas, 129X1/SvJ, 129S1/Sv, DBA/2J, and possibly others.
STOCK Terctm1Rdp Trp53tm1Tyj/+ targeted mutation (knockout) Mice were homozygous for the Terc mutant allele and heterozygous for the Trp53 mutan allele. This STOCK genetic background was a mixture predominantly of C57BL/6, 129S2/SvPas, & 129/Sv (substrain unspecified), and it also included some SJL.
STOCK Tg(Ela1-Tgfa)150Bri Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice carried the Tg(Ela1-Tgfa)150Bri transgene & were heterozygous for the Trp53tm1Tyj allele. The genetic background of these mice was predominantly a mixture of C57BL/6 & BALB/c with some SJL and/or 129S2/SvPas also possibly involved.
STOCK Tg(Ela1-Tgfa)150Bri Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
These mice carried the Tg(Ela1-Tgfa)150Bri transgene and were heterozygous for the Trp53tm1Tyj allele. This STOCK genetic background was a mixture of C57BL/6, BALB/c, 129S2/SvPas, and likely some SJL.
STOCK Tg(Ela1-Tgfa)150Bri Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
These mice carried the Tg(Ela1-Tgfa)150Bri transgene & were heterozygous for the Trp53tm1Tyj allele. This STOCK genetic background was a mixture of ~50% C57BL/6 and ~50% BALB/c with some contribution from 129S2/SvPas and also likely SJL.
STOCK Tg(Ela1-Tgfa)150Bri Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. This STOCK genetic background was a mixture of C57BL/6, BALB/c, 129S2/SvPas and likely some SJL and was either ~50% B6 and ~50% BALB/c or backcrossed several times to BALB/c (pooled populations).
STOCK Tg(GFAP-E2F1)10Fyo Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice were heterozygous for the Trp53 allele and carried the transgene. This STOCK genetic background was primarily a mixture of FVB and C57BL/6J with some contribution from 129S2/SvPas.
STOCK Tg(GFAP-TAg121)1Tvd Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice were heterozygous for the Trp53tm1Tyj allele and carried the Tg(GFAP-TAg121)1Tvd transgene. The genetic background was a mix involving C57BL/6NCrlBR, DBA/2NCrlBR, and FVB.
STOCK Tg(GFAP-cre)25Mes Nf1tm1Par Trp53tm1Tyj/+ + targeted mutation (conditional) &
targeted mutation (knockout) &
transgenic
Compound mutant mice. The targeted mutant alleles are in "cis" on chr. 11. This STOCK genetic background was a mixture of C57BL/6 (~49.5%), 129X1/SvJ ~(49.5%), and FVB (~1%). It also contained some amount of 129S1/Sv and 129S2/SvPas.
STOCK Tg(LPV-TAg121)2Tvd Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice were heterozygous for the Trp53 mutant allele & carried the Tg(LPV-TAg121)2Tvd transgene. This STOCK genetic background was a mixture of at least C57BL/6J, DBA/2J, & 129S2/SvPas. It may also contain another 129 substrain, possibly 129S4/SvJae.
STOCK Tg(MMTV-Myc)141-3Led Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. The genetic background of these mice was a mixture of mostly FVB and 129 (substrains not specified but contained at least 129S2/SvPas and "129/Sv") and also some CD-1 and C57BL/6J.
STOCK Tg(MtTGFA)100Lmb Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice were heterozygous for the Trp53tm1Tyj allele and carried the Tg(MtTGFA)100Lmb transgene. This STOCK genetic background was made up of FVB/N, 129S2/SvPas, and possibly some 129/Sv, C57BL/6J, and SJL.
STOCK Tg(MtTGFA)42Lmb Cdkn2atm1Rdp/+ Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice were heterozygous for the Cdkn2a and Trp53 alleles and carried the Tg(MtTGFA)42Lmb transgene. This STOCK genetic background was a mixture predominantly of C57BL/6 and CD-1 and also included 129/Sv, 129S2/SvPas, and SJL.
STOCK Tg(MtTGFA)42Lmb Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice were heterozygous for the Trp53tm1Tyj allele and carried the Tg(MtTGFA)42Lmb transgene. This STOCK genetic background was a mixture predominantly of C57BL/6 and CD-1 and also included 129S2/SvPas and possibly some 129/Sv and SJL.
STOCK Tg(Nes-cre)1Kln Trp53tm1Tyj/+ Xccr2tm2Pmc targeted mutation (conditional) &
transgenic
Mice were homozygous for Xccr2tm2Pmc and heterozygous for Trp53tm1Tyj and carried the Tg(Nes-cre)1Kln transgene. The genetic background contained contributions from 129S2/SvPas, C57BL/6, and SJL.
STOCK Tg(Scgb1a1-rtTA)1Jaw Tg(tetO-EGFR*L858R)56Hev Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Heterozygous mutant mice carrying two transgenes on a STOCK genetic background that was a mixture of at least FVB/N, C57BL/6, 129S2/SvPas and CBA.
STOCK Tg(Scgb1a1-rtTA)1Jaw Tg(tetO-EGFR*delta19)11Hev Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Heterozygous mutant mice carrying two transgenes on a STOCK genetic background that was a mixture of at least FVB/N, C57BL/6, 129S2/SvPas and CBA.
STOCK Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. This STOCK genetic background of these mice was ~50% C57BL/6 and ~50% BALB/c with some SJL and/or 129S2/SvPas also possibly involved.
STOCK Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. This STOCK genetic background was predominantly C57BL/6 and 129S2/SvPas, and may also include some 129/Sv (substrain unspecified) and some SJL.
STOCK Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. This STOCK genetic background included C57BL/6, 129S2/SvPas, and Mus spretus.
STOCK Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was a mixture of mostly FVB and 129 (substrains not specified but contained at least 129S2/SvPas and "129/Sv") and possibly some CD-1 and C57BL/6J.
STOCK Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. This STOCK genetic background is a mixture of C57BL/6J, DW/J, CAST/Ei, and 129S2/SvPas.
STOCK Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. This STOCK genetic background was a mixture of CD-1, C57BL/6, and 129S2/SvPas. It may also include some 129X1/SvJ and/or some 129S1/Sv.
STOCK Trp53tm1Tyj/+ Tg(SFTPC-RAF1-BxB)1Urr targeted mutation (knockout) &
transgenic
Hemizygous transgenic mice, heterozygous for the Trp53tm1Tyj allele. Background was said to be ~92.5% C57BL/6 and 7.5% DBA/2, but includes some contribution from 129S2/SvPas as the background of original Trp53 knockout mouse.
(129S4.129S2 x C57BL/6J)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
129S4.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + "cis" (mutations both carried on the same copy of chromosome 11) female mice were bred to male C57BL/6J mice.
(129S4/SvJae x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
129S4/SvJae female mice were bred to male B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + "cis" mice (both mutations on the same copy of chromosome 11).
(A/J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
These mice were heterozygous for Nf1tm1Tyj & Trp53tm1Tyj on the same chromosome 11 ("cis"). Genetic background was approximately 50% A/J and 50% C57BL/6J. The sex of the mutant mice used in this cross was not given.
(B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + x C57BL/6J-Chr 19A/J/NaJ) consomic &
targeted mutation (knockout)
This cohort was generated by breeding females backcrossed to C57BL/6J & carrying one copy of each mutation on the same copy of chr 11 ("cis") with consomic C57BL/6J-Chr 19A/J/NaJ males. The mutant alleles were derived from the maternal parent.
(B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + x C67BL/6J) congenic &
targeted mutation (knockout)
This cohort was generated by breeding female mice backcrossed to C57BL/6J and carrying one copy of each mutation on the same copy of chromosome 11 ("cis") with C57BL/6J male mice. The mutant alleles were derived from the maternal parent.
(C3H/HeJ x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj and Trp53tm1Tyj on the same copy of chromosome 11 ("cis"). The background of these mice was 50% C3H/HeJ.
(C57BL/6J x 129S4.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
C57BL/6J female mice were bred to male 129S4.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + "cis" (alleles on the same copy of chromosome 11) mice.
(C57BL/6J-Chr 19A/J/NaJ x B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ +) consomic &
targeted mutation (knockout)
This cohort was generated by breeding consomic C57BL/6J-Chr 19A/J/NaJ females with males backcrossed to C57BL/6J & carrying one copy of each mutation on the same copy of chr 11 ("cis"). The mutant alleles were derived from the paternal parent.
(C67BL/6J x B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ +) congenic &
targeted mutation (knockout)
This cohort was generated by breeding C57BL/6J female mice with male mice backcrossed to C57BL/6J and carrying one copy of each mutation on the same copy of chromosome 11 ("cis"). The mutant alleles were derived from the paternal parent.
(CAST/EiJ x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj and Trp53tm1Tyj on the same copy of chromosome 11 ("cis"). The background of these mice was 50% CAST/EiJ.
(CBA/J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
These mice were heterozygous for Nf1tm1Tyj & Trp53tm1Tyj on the same chromosome 11 ("cis"). Genetic background was approximately 50% CBA/J and 50% C57BL/6J. The sex of the mutant mice used in this cross was not given.
(DBA/2J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
These mice were heterozygous for Nf1tm1Tyj & Trp53tm1Tyj on the same chromosome 11 ("cis"). Genetic background was approximately 50% DBA/2J and 50% C57BL/6J. The sex of the mutant mice used in this cross was not given.
(FVB/NJ x C3H/HeJ)F2 hybrid F2 generation of a cross between (FVB/NJ x C3H/HeJ)F1 mice.
(SJL/J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj and Trp53tm1Tyj on the same copy of chromosome 11 ("cis"). The background of these mice was 50% SJL/J.
[not specified]-Brca1tm1Bhk/+ Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background of these mice was not specified but involved at least some 129P2/OlaHsd and 129S2/SvPas from the ES cells used to generate the mutant alleles.
[not specified]-Cdk6tm1.1Mama Trp53tm1Tyj/+ targeted mutation (knock-in) &
targeted mutation (knockout)
Compound mutant mice. The genetic background of these mice was not specified but included 129 (at least 129S2/SvPas), likely some BALB/cJ, and possibly some other strain(s).
[not specified]-Cdkn2ctm1Bbd/+ Trp53tm1Tyj/+ targeted mutation (knockout) These mice were heterozygous for both mutant alleles. The genetic background of these mice was not specified but included at least 129S1/Sv and 129S2/SvPas.
[not specified]-Ets2tm5.2Rgo/+ Nf1tm1Tyj/+ Trp53tm1Tyj/+ targeted mutation (knockout) Triple heterozygous mice. The genetic background of these mice was either predominantly C57BL/6J (from crossing congenics) or a STOCK that included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
[not specified]-Gt(ROSA)26Sortm1(cre/ERT2)Alj Igs2tm1(ACTB-EGFP,-tdTomato)Luo/Igs2tm2(ACTB-tdTomato,-EGFP)Luo Krastm3Tyj/+ Trp53tm1Tyj/+ targeted mutation (knock-in) &
targeted mutation (knockout) &
targeted mutation (other)
Compound mutant mice. The genetic background was an undefined mixture that included at least some 129S4/SvJae, 129S2/SvPas, and also 129X1/SvJ and/or 129S1/Sv. There may have been other strain contributions.
[not specified]-Igs2tm1(ACTB-EGFP,-tdTomato)Luo/Igs2tm2(ACTB-tdTomato,-EGFP)Luo Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout) &
targeted mutation (other) &
transgenic
Compound mutant mice. The genetic background was an undefined mixture that included at least some 129S4/SvJae, 129S2/SvPas, FVB/N, and also 129X1/SvJ and/or 129S1/Sv. There may have been other strain contributions.
[not specified]-Igs2tm1(ACTB-EGFP,-tdTomato)Luo/Igs2tm2(ACTB-tdTomato,-EGFP)Luo Krastm4Tyj/+ Trp53tm1Tyj/+ targeted mutation (conditional) &
targeted mutation (knockout) &
targeted mutation (other)
Compound mutant mice. The genetic background was an undefined mixture that included at least some 129S4/SvJae, 129S2/SvPas, and also 129X1/SvJ and/or 129S1/Sv. There may have been other strain contributions.
[not specified]-Krastm2Tyj/+ Trp53tm1Tyj/+ targeted mutation (knock-in) &
targeted mutation (knockout)
Mice heterozygous for targeted mutations of Kras and Trp53. Spontaneous somatic recombination leads to the expression of an activated oncogenic KRAS protein. The genetic background was not specified.
[not specified]-Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv Trp53tm1Tyj/+ targeted mutation (conditional) &
transgenic
Heterozygous Kras, Trp53 mice carrying the transgene on an unspecified background with contribution from C57BL/6, 129S4/SvJae, 129S2/SvPas, and FVB/N.
[not specified]-Lig4tm1Icrf Trp53tm1Tyj/+ targeted mutation (knockout) Homozygous Lig4tm1Icrf heterozygous Trp53tm1Tyj mice. The genetic background was not specified, but included contributions from C57BL/6, 129S2/SvPas, other unspecified substrain(s) of 129, and possibly other strains.
[not specified]-Mad1l1tm1.1Ktj/+ Mad2l1tm1Sorg/+ Trp53tm1Tyj/+ targeted mutation (knockout) Triple heterozygous mice. The genetic background was reported to be a mixture of C57BL/6 and "129/Sv" (substrain not specified) but it also likely included some BALB/c and possibly some other strain(s).
[not specified]-Mad1l1tm1.1Ktj/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background was reported to be a mixture of C57BL/6 and "129/Sv" (substrain not specified) but it also likely included some BALB/c and possibly some other strain(s).
[not specified]-Mad2l1tm1Sorg/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background was reported to be a mixture of C57BL/6 and "129/Sv" (substrain not specified) but it also likely included some BALB/c and possibly some other strain(s).
[not specified]-Nf1tm1Tyj Trp53tm1Tyj/+ + targeted mutation (knockout) Double heterozygous mice in "cis". The genetic background of these mice was either predominantly C57BL/6J (from crossing congenics) or a STOCK that included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
[not specified]-Nf2tm1Tyj +/+ Trp53tm1Tyj targeted mutation (knockout) Mice are heterozygous for both Nf2tm1Tyj & Trp53tm1Tyj & carry each allele on opposite copies of chromosome 11 (in "trans"). The reference did not specify the genetic background, either mixed B6;129S or inbred 129S/Sv.
[not specified]-Nf2tm1Tyj Trp53tm1Tyj/+ + targeted mutation (knockout) Mice are heterozygous for both Nf2tm1Tyj and Trp53tm1Tyj and carry both alleles on the same copy of chromosome 11 (in "cis"). The reference did not specify the genetic background, either mixed B6;129S or inbred 129S/Sv.
[not specified]-Prdm2tm1Shg Trp53tm1Tyj/+ targeted mutation (knockout) Homozygous Prdm2, heterozygous Trp53 mutant mice on an unspecified background with contributions from C57BL/6, 129/Sv, and possibly 129S2/SvPas.
[not specified]-Prdm2tm1Shg/+ Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Prdm2, Trp53 mutant mice on an unspecified background with contributions from C57BL/6, 129/Sv, and possibly 129S2/SvPas.
[not specified]-Ptch1tm1Mps/+ Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice heterozygous for both the Trp53tm1Tyj and the Ptch1tm1Mps alleles. Background was not specified but includes contributions from C57BL/6 and C57BL/6J, 129X1/SvJ, 129S1/Sv, 129S2/SvPas, and DBA/2J.
[not specified]-Ptentm1.1Whs/+ Trp53tm1Tyj/+ targeted mutation (knock-in) &
targeted mutation (knockout)
Double heterozygous mice. The genetic background of these mice was not specified but included at least some C57BL/6, 129S6/SvEvTac, and 129S2/SvPas.
[not specified]-Susd6tm1.1Geno Trp53tm1Tyj/+ targeted mutation (knockout) Compound mutant mice. The genetic background was not specified but included C57BL/6J (at least 50%) and some 129S2/SvPas.
[not specified]-Susd6tm1.1Geno/+ Trp53tm1Tyj/+ targeted mutation (knockout) Double heterozygous mice. The genetic background was not specified but included C57BL/6J (at least 50%) and some 129S2/SvPas.
[not specified]-Tg(Actb-Mdm4,-lacZ)1Glo Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. The genetic background of these mice was not specified but contained at least some C57BL/6J and some 129S2/SvPas.
[not specified]-Tg(KRT5-Tert)7664Blas Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Transgenic mice heterozygous for the Trp53tm1Tyj allele. The genetic background was not specified but contained contributions from at least C57BL/6, DBA/2, and 129S2/SvPas.
[not specified]-Tg(KRT5-Tert)8043Blas Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Transgenic mice heterozygous for the Trp53tm1Tyj allele. The genetic background was not specified but contained contributions from at least C57BL/6, DBA/2, and 129S2/SvPas.
[not specified]-Tg(Scgb1a1-rtTA)1Jaw Tg(tetO-EGFR*L858R)56Hev Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. The genetic background of these mice was not specified. It likely included at least some 129 (including some 129S2/SvPas), C57BL/6, and CBA.
[not specified]-Tg(Scgb1a1-rtTA)1Jaw Tg(tetO-EGFR*L858R)57Hev Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. The genetic background of these mice was not specified. It likely included at least some 129 (including some 129S2/SvPas), C57BL/6, and CBA.
[not specified]-Tg(Scgb1a1-rtTA)1Jaw Tg(tetO-EGFR*delta19)11Hev Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. The genetic background of these mice was not specified. It likely included at least some 129 (including some 129S2/SvPas), C57BL/6, and CBA.
[not specified]-Tg(Tyr-HRAS)60Lc Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Mice heterozygous for a targeted mutation of Trp53 and transgenic for an activated human HRAS (G12V) oncogene under control of the melanocyte-specific mouse tyrosinase promoter. Genetic background was not specified.
[not specified]-Tg(WAPT121)66Tvd Trp53tm1Tyj/+ targeted mutation (knockout) &
transgenic
Compound mutant mice. The genetic background of these mice was not specified but included at least some C57BL/6J, DBA/2J, and 129S2/SvPas.
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was not specified but involved at least some 129S2/SvPas from the ES cells used to generate the mutant allele.
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The full genetic background was not specified but was reported to be predominantly 129S4/SvJae. It also included some 129S2/SvPas.
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) These mice were heterozygous for the Trp53tm1Tyj allele. The genetic background was unspecified but contained contributions from at least C57BL/6, DBA/2, and 129S2/SvPas.
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background was reported to be a mixture of C57BL/6 and "129/Sv" (substrain not specified) but it also likely included some BALB/c and possibly some other strain(s).
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous Trp53 mutant mice on an unspecified background with contributions from C57BL/6, 129/Sv, and possibly 129S2/SvPas.
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was not specified but contained at least some C57BL/6J and some 129S2/SvPas.
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background was not specified but included C57BL/6J (at least 50%) and some 129S2/SvPas.
[not specified]-Trp53tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was not specified but included 129 (at least 129S2/SvPas), likely some BALB/cJ, and possibly some other strain(s).
[not specified]-Trp53tm1Tyj/+ Tg(SFTPC-RAF1-BxB)1Urr targeted mutation (knockout) &
transgenic
Hemizygous transgenic mice, heterozygous for the Trp53tm1Tyj allele. Background was not specified and could be either 75% '129/Sv' 25% C57BL/6 x DBA/2, or 92.5% C57BL/6 and 7.5% DBA/2 plus residual contribution from 129S2/SvPas.
[not specified]-Trp53tm1Tyj/+ Xrcc4tm1Fwa targeted mutation (knockout) Mice homozygous for a targeted mutation of the Xrcc4 gene and heterozygous for Trp53. The genetic background was not specified.