Mouse Tumor Biology Database (MTB)
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MTB 3.0
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Strain Name Strain Type Strain Notes
STOCK Brca1tm2.1Cxd/+ Trp53tm1Brd/+ targeted mutation (knockout) Mice heterozygous for a hypomorphic Brca1 targeted mutation & a targeted loss-of-function Trp53 mutation. The genetic background was a mix of FVB, 129S7/SvEvBrd-Hprt+, 129S6/SvEvTac, and possibly some 129, and Black Swiss.
[not specified]-Brca1tm2.1Cxd/+ Chek2tm1Nmt targeted mutation (knockout) Mice were heterozygous for the Brca1 allele and homozygous for the Chek2 allele. The genetic background of these mice was not specified. It included at least some 129S6/SvEvTac and some 129P2/OlaHsd.