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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Strain Search Results  
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27 matching items displayed.
Strain Name Strain Type Strain Notes
129S-Nf1tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The ES cell line used to generate this strain was D3 (129S2/SvPas). Mice were subsequently crossed to 129S4/SvJae.
129S4.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + congenic &
targeted mutation (knockout)
Mice heterozygous for Nf1 and Trp53 mutations on 129S4.129S2 backgrounds were crossed to make "trans" mice (alleles on opposite chromosomes). Mice were crossed to 129S4/SvJae mice to produce "cis" mice (alleles on the same chromosome).
B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + congenic &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj were crossed with Trp53tm1Tyj heterozygotes to generate mice carrying both mutations on the same copy of chromosome 11 ("cis"). These "NPcis" mice were backcrossed to C57BL/6J.
B6129F1-Nf1tm1Tyj hybrid &
targeted mutation (knockout)
Heterozygous mice on a (C57BL/6 x 129/Sv)F1 genetic background with possible contribution from 129S2/SvPas.
B6;129-Nf1tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of these mice was approximately 50% C57BL/6 and 50% "129/Sv" (substrain(s) usnpecified but included at least 129S2/SvPas).
B6;129S-Nf1tm1Tyj/+ targeted mutation (knockout) Heterozygous mice. The genetic background of this strain is a mixture of C57BL/6, 129S2/SvPas, and 129S4/SvJae.
B6;129S2-Nf1tm1Tyj +/+ Trp53tm1Tyj targeted mutation (knockout) Mice heterozygous for targeted mutations of Trp53 and Nf1 on opposite chromosomes 11 ("trans"). The genetic background of these mice is a mixture of C57BL/6 and 129S2/SvPas.
B6;129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + targeted mutation (knockout) Mice heterozygous for targeted mutations of Trp53 and Nf1 on the same chromosome 11 ("cis"). The genetic background of these mice is a mixture of C57BL/6 and 129S2/SvPas.
STOCK Ets2tm5.2Rgo/+ Nf1tm1Tyj/+ Trp53tm1Tyj/+ Ts(1716)65Dn radiation induced mutation &
targeted mutation (knockout)
Triple heterozygous mice carrying a trisomy mutation. This STOCK genetic background included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
STOCK Nf1tm1Tyj/+ Trp53tm1Tyj/+ Ts(1716)65Dn radiation induced mutation &
targeted mutation (knockout)
Double heterozygous mice carrying a trisomy mutation. This STOCK genetic background included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
(129S4.129S2 x C57BL/6J)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
129S4.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + "cis" (mutations both carried on the same copy of chromosome 11) female mice were bred to male C57BL/6J mice.
(129S4/SvJae x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
129S4/SvJae female mice were bred to male B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + "cis" mice (both mutations on the same copy of chromosome 11).
(A/J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
These mice were heterozygous for Nf1tm1Tyj & Trp53tm1Tyj on the same chromosome 11 ("cis"). Genetic background was approximately 50% A/J and 50% C57BL/6J. The sex of the mutant mice used in this cross was not given.
(B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + x C57BL/6J-Chr 19A/J/NaJ) consomic &
targeted mutation (knockout)
This cohort was generated by breeding females backcrossed to C57BL/6J & carrying one copy of each mutation on the same copy of chr 11 ("cis") with consomic C57BL/6J-Chr 19A/J/NaJ males. The mutant alleles were derived from the maternal parent.
(B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + x C67BL/6J) congenic &
targeted mutation (knockout)
This cohort was generated by breeding female mice backcrossed to C57BL/6J and carrying one copy of each mutation on the same copy of chromosome 11 ("cis") with C57BL/6J male mice. The mutant alleles were derived from the maternal parent.
(C3H/HeJ x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj and Trp53tm1Tyj on the same copy of chromosome 11 ("cis"). The background of these mice was 50% C3H/HeJ.
(C57BL/6 x 129/Sv)F1-Nf1tm1Tyj/+ hybrid &
targeted mutation (knockout)
Heterozygous Nf1 mice on a hybrid background from a (C57BL/6 x 129/Sv)F1 cross with contribution from 129S2/SvPas.
(C57BL/6J x 129S4.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
C57BL/6J female mice were bred to male 129S4.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ + "cis" (alleles on the same copy of chromosome 11) mice.
(C57BL/6J-Chr 19A/J/NaJ x B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ +) consomic &
targeted mutation (knockout)
This cohort was generated by breeding consomic C57BL/6J-Chr 19A/J/NaJ females with males backcrossed to C57BL/6J & carrying one copy of each mutation on the same copy of chr 11 ("cis"). The mutant alleles were derived from the paternal parent.
(C67BL/6J x B6.129S2-Nf1tm1Tyj Trp53tm1Tyj/+ +) congenic &
targeted mutation (knockout)
This cohort was generated by breeding C57BL/6J female mice with male mice backcrossed to C57BL/6J and carrying one copy of each mutation on the same copy of chromosome 11 ("cis"). The mutant alleles were derived from the paternal parent.
(CAST/EiJ x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj and Trp53tm1Tyj on the same copy of chromosome 11 ("cis"). The background of these mice was 50% CAST/EiJ.
(CBA/J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
These mice were heterozygous for Nf1tm1Tyj & Trp53tm1Tyj on the same chromosome 11 ("cis"). Genetic background was approximately 50% CBA/J and 50% C57BL/6J. The sex of the mutant mice used in this cross was not given.
(DBA/2J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
These mice were heterozygous for Nf1tm1Tyj & Trp53tm1Tyj on the same chromosome 11 ("cis"). Genetic background was approximately 50% DBA/2J and 50% C57BL/6J. The sex of the mutant mice used in this cross was not given.
(SJL/J x B6.129S2)F1-Nf1tm1Tyj Trp53tm1Tyj/+ + hybrid &
targeted mutation (knockout)
Mice heterozygous for Nf1tm1Tyj and Trp53tm1Tyj on the same copy of chromosome 11 ("cis"). The background of these mice was 50% SJL/J.
[not specified]-Ets2tm5.2Rgo/+ Nf1tm1Tyj/+ Trp53tm1Tyj/+ targeted mutation (knockout) Triple heterozygous mice. The genetic background of these mice was either predominantly C57BL/6J (from crossing congenics) or a STOCK that included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
[not specified]-Nf1tm1Tyj Trp53tm1Tyj/+ + targeted mutation (knockout) Double heterozygous mice in "cis". The genetic background of these mice was either predominantly C57BL/6J (from crossing congenics) or a STOCK that included C57BL/6J, C57BL/6JEi, C3H/HeJ, C3H/HeSnJ, DBA/2J, 129S2/SvPas and possibly other strain(s).
[not specified]-Nf1tm1Tyj/+ Tg(Th-MYCN)#Waw targeted mutation (knockout) &
transgenic
Mice were hemizygous for Tg(ThMYCN)#Waw and heterozgyous for Nf1tm1Tyj. The genetic background of this strain was not specified but contained at least C57BL/6J, BALB/c, and 129S2/SvPas. (# - founder number not specified)