Strain Tumor Overview (Expanded View)

Strain

[not specified]-Cdkn2atm2.1Nesh/+ Krastm4Tyj/+ Tg(Tyr-cre/ERT2)13Bos Trp53tm1Brn/+

Strain Synonyms

Tyr-CRE-ERT2 + KRasLSL/+ p16L/+p53L/+  •  Tyr-CRE-ERT2 Lox-Stop-Lox-KRasG12D p16L/+ p53L/+  •  TKp16L/+p53L/+

Strain Note:

Compound mutant mice. The genetic background was not specified but was ~50% C57BL/6 (described as "N1" onto that strain) and may have included some FVB, 129S4/SvJae, 129P2/OlaHsd, and possibly some other strain(s).

Tumors

2 unique tumor sub-types displayed. A tumor sub-type is a set of tumors that share the same tumor name, organ affected, treatment agent, and metastatic status/localization.
Tumor Name Organ(s) Affected Treatment Type Agents Metastasizes To References Number of Tumor Sub-type Records Frequency Range
Eye - Uvea - Melanocyte melanoma Eye - Uvea - Melanocyte Genetic Modification 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles) J:164588 1 0
Skin - Melanocyte melanoma - amelanotic Skin - Melanocyte Genetic Modification 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles) not (Unspecified organ) J:164588 2 43