Strain Tumor Overview (Expanded View)

Strain

B6;129-Cdkn2atm1Cjs/+ Mdm2tm1Glo/+ Trp53tm1Tyj

Strain Synonyms

a+/-p-/-m+/-  •  Mdm2+/-Arf+/-p53-/-  •  m+/-a+/-p-/-

Strain Note:

Compound mutant mice. The genetic background of these mice was a mixture of C57BL/6 (64%) and 129/Sv (36%). The "129/Sv" was a combination of at least 129S2/SvPas, 129S7/SvEvBrd-Hprt+, and 129X1/SvJ.

Tumors

12 unique tumor sub-types displayed. A tumor sub-type is a set of tumors that share the same tumor name, organ affected, treatment agent, and metastatic status/localization.
Tumor Name Organ(s) Affected Treatment Type Agents Metastasizes To References Number of Tumor Sub-type Records Frequency Range
Blood vessel hemangioma Blood vessel None (spontaneous) J:192121 1 0
Blood vessel hemangiosarcoma Blood vessel None (spontaneous) J:192121 1 24
Bone osteosarcoma Bone None (spontaneous) J:192121 1 0
CNS tumor CNS None (spontaneous) J:192121 1 0
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte None (spontaneous) J:192121 1 4.8
Leukocyte lymphoma Leukocyte None (spontaneous) J:192121 1 76
Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast None (spontaneous) J:192121 2 14 - 43
Muscle - Smooth leiomyoma Muscle - Smooth None (spontaneous) J:192121 1 0
(Unspecified organ) adenoma (Unspecified organ) None (spontaneous) J:192121 1 0
(Unspecified organ) carcinoma (Unspecified organ) None (spontaneous) J:192121 1 0
(Unspecified organ) carcinosarcoma (Unspecified organ) None (spontaneous) J:192121 1 0
(Unspecified organ) tumor (Unspecified organ) None (spontaneous) J:192121 1 100