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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Strain Tumor Overview
Expanded View
 
Strain
C57BL/6
Strain Synonyms B6  •  B6 wild-type  •  C57  •  C57/B16  •  C57B1/6  •  C57BL  •  C57Bl6  •  C57BL6  •  C57BL/6 wild-type  •  C57BL/6 WT  •  p53+/+  •  pure C57BL/6  •  wild-type  •  wild type C57BL/6  •  WT
Strain Note: Substrain not specified.
Strain Tumor Overview Collapsed View
Tumors 92 unique tumor sub-types displayed.

A tumor sub-type is a set of tumors that share the same tumor name, organ affected, treatment agent, and metastatic status/localization.

Tumor Name Organ(s) Affected Treatment Type
Agents
Metastasizes
To
References Number of
Tumor Sub-type Records
Frequency Range
Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Cortex None (spontaneous)
  J:44011 2 0 - 87
Blood vessel hemangiosarcoma Blood vessel None (spontaneous)
  J:235854 1 observed
CNS - Brain - Astrocyte astrocytoma CNS - Brain - Astrocyte None (spontaneous)
  J:40335
J:64364
2 0
CNS - Brain glioma CNS - Brain Virus
Moloney Murine Leukemia helper virus
Moloney Murine Leukemia Virus (MoMuLV) containing Pdgfb
  J:91806 1 observed
CNS - Brain tumor CNS - Brain Virus
MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)
murine retrovirus containing human PDGFB cDNA
  J:51373 1 43
CNS - Brain tumor CNS - Brain Virus
MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)
  J:51373 1 0
Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast None (spontaneous)
  J:242785 1 0
Esophagus tumor Esophagus None (spontaneous)
  J:52691 1 0
Esophagus tumor Esophagus Chemical/Drug
rebamipide
  J:52691 1 0
Esophagus tumor Esophagus Chemical/Drug
N-ethyl-N'-nitro-N-nitroguanidine (ENNG)
  J:52691 1 0
Esophagus tumor Esophagus Chemical/Drug
rebamipide
N-ethyl-N'-nitro-N-nitroguanidine (ENNG)
  J:52691 1 0
Gallbladder normal tissue (control) Gallbladder None (spontaneous)
  J:94307 1 not applicable
Intestine - Large Intestine - Colon hyperplasia Intestine - Large Intestine - Colon Chemical/Drug
piroxicam
  J:52249 1 observed
Intestine - Small Intestine - Duodenum adenocarcinoma Intestine - Small Intestine - Duodenum Chemical/Drug
N-ethyl-N'-nitro-N-nitroguanidine (ENNG)
  J:52691 1 67
Intestine - Small Intestine - Duodenum adenocarcinoma Intestine - Small Intestine - Duodenum Chemical/Drug
rebamipide
N-ethyl-N'-nitro-N-nitroguanidine (ENNG)
  J:52691 2 42 - 55
Intestine - Small Intestine - Duodenum tumor Intestine - Small Intestine - Duodenum None (spontaneous)
  J:52691 1 0
Intestine - Small Intestine - Duodenum tumor Intestine - Small Intestine - Duodenum Chemical/Drug
rebamipide
  J:52691 1 0
Intestine adenoma Intestine None (spontaneous)
  J:72233 1 0
Intestine adenoma Intestine Chemical/Drug
aspirin (acetylsalicylic acid) (ASA)
  J:72233 2 0
Kidney adenocarcinoma Kidney None (spontaneous)
  J:242785 1 0
Kidney cyst Kidney None (spontaneous)
  J:242785 1 5.56
Leukocyte - Lymphocyte leukemia Lymphoid tissue None (spontaneous)
  J:164423 1 observed
Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte None (spontaneous)
  J:97121 1 2
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte None (spontaneous)
  J:38438 2 10 - 22
Leukocyte leukemia Leukocyte None (spontaneous)
  J:50296
J:97121
2 7.0 - 16.0
Leukocyte lymphoma Leukocyte Virus
A-MuLV - Abelson murine leukemia virus (A-MuLV-P160)
  J:24306 3 4.9 - 80
Leukocyte lymphoma Leukocyte Virus
MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)
  J:24306 2 0 - 33
Leukocyte lymphoma Leukocyte Chemical/Drug
methylcholanthrene (MCA)
  J:97121 1 high
Leukocyte lymphoma Leukocyte Chemical/Drug
vinyl carbamate (VC)
  J:16464 1 100
Leukocyte lymphoma Leukocyte None (spontaneous)
  J:242785 1 5.56
Liver adenoma Liver Chemical/Drug
dimethyl sulfoxide (DMSO)
  J:57142 1 0
Liver adenoma Liver Chemical/Drug
dimethylnitrosamine (DMN)
  J:57142 2 33.33 - 76.47
Liver adenoma Liver Chemical/Drug
6-nitrochrysene (6-NC)
  J:57142 2 83.33 - 88.89
Liver adenoma Liver Chemical/Drug
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
  J:57142 2 5.56 - 7.14
Liver hepatocellular carcinoma Liver None (spontaneous)
  J:164423 1 0
Liver hepatocellular carcinoma Liver Radiation
radiation - unspecified type
  J:164423 1 11.11
Liver hepatoma Liver Radiation
radiation - unspecified type
  J:50296 1 high
Liver hepatoma Liver None (spontaneous)
  J:242785 1 11.11
Liver preneoplastic lesion Liver Chemical/Drug
diethylnitrosamine (DEN)
  J:89140 1 observed
Lung adenocarcinoma Lung Chemical/Drug
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
  J:16464 1 observed
Lung adenocarcinoma Lung Chemical/Drug
vinyl carbamate (VC)
  J:16464 1 observed
Lung adenocarcinoma Lung None (spontaneous)
  J:34127 1 0
Lung adenocarcinoma Lung Chemical/Drug
benzo[a]pyrene (BP) (BaP) (B[a]P)
  J:34127 1 42
Lung adenoma Lung Chemical/Drug
vinyl carbamate (VC)
  J:16464 1 observed
Lung adenoma Lung None (spontaneous)
  J:145754
J:242785
J:34127
3 0 - 5.56
Lung adenoma Lung Chemical/Drug
benzo[a]pyrene (BP) (BaP) (B[a]P)
  J:34127 1 0
Lung adenoma Lung Chemical/Drug
mainstream cigarette smoke (MCS)
  J:145754 1 10
Lung carcinoma Lung Chemical/Drug
mainstream cigarette smoke (MCS)
  J:145754 1 0
Lung carcinoma Lung None (spontaneous)
  J:145754 1 0
Lung hyperplasia Lung Chemical/Drug
benzo[a]pyrene (BP) (BaP) (B[a]P)
  J:34127 1 observed
Lung hyperplasia Lung None (spontaneous)
  J:145754 1 observed
Lung hyperplasia Lung Chemical/Drug
mainstream cigarette smoke (MCS)
  J:145754 1 observed
Lung papilloma Lung None (spontaneous)
  J:145754 1 0
Lung papilloma Lung Chemical/Drug
mainstream cigarette smoke (MCS)
  J:145754 1 0
Lung squamous cell carcinoma Lung None (spontaneous)
  J:34127 1 0
Lung squamous cell carcinoma Lung Chemical/Drug
benzo[a]pyrene (BP) (BaP) (B[a]P)
  J:34127 1 23
Lung tumor Lung None (spontaneous)
  J:145754
J:16464
J:67488
J:97121
7 0 - 4.4
Lung tumor Lung Chemical/Drug
N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  J:97121 1 observed
Lung tumor Lung Chemical/Drug
N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
beta-naphthoflavone (betaNF)
  J:97121 1 observed
Lung tumor Lung Chemical/Drug
environmental cigarette smoke (ECS)
  J:67488 1 0
Lung tumor Lung Chemical/Drug
N-acetyl-L-cysteine (NAC)
environmental cigarette smoke (ECS)
  J:67488 1 0
Lung tumor Lung Chemical/Drug
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
  J:16464 2 18
Lung tumor Lung Chemical/Drug
vinyl carbamate (VC)
  J:16464 1 46
Lung tumor Lung Genetic Modification
Adenovirus - recombinant, expressing Jaagsiekte sheep retrovirus envelope protein
Adenovirus - recombinant, expressing human alkaline phosphatase
  J:98116 1 50
Lung tumor Lung Genetic Modification
Adenovirus - recombinant, expressing human alkaline phosphatase
Adenovirus - recombinant, expressing Jaagsiekte sheep retrovirus envelope protein
  J:98116 1 0
Lung tumor Lung Chemical/Drug
mainstream cigarette smoke (MCS)
  J:145754 2 observed - 10
Lymphoid tissue lymphoma Lymphoid tissue None (spontaneous)
  J:87359 1 0
Mammary gland adenocarcinoma Mammary gland None (spontaneous)
  J:97121 1 1
Mammary gland normal tissue (control) Mammary gland None (spontaneous)
  J:227323 1 not applicable
Mammary gland tumor Mammary gland None (spontaneous)
  J:55930 2 very low - low
Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast Chemical/Drug
3-methylcholanthrene (MCA) (3-MC)
  J:97121 1 observed
Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast None (spontaneous)
  J:164423 1 observed
Ovary tumor Ovary Genetic Modification
Ad5-CMV-Cre (AdCre) (AdCMVCre)
  J:120955 1 0
Pancreas normal tissue (control) Pancreas None (spontaneous)
  J:94307 1 not applicable
Pituitary gland tumor Pituitary gland None (spontaneous)
  J:24830
J:50296
3 observed - 61
Prostate gland normal tissue (control) Prostate gland None (spontaneous)
  J:124885 1 not applicable
Prostate gland tumor Prostate gland Hormone
castration
  J:65876 1 0
Seminal vesicle normal tissue (control) Seminal vesicle None (spontaneous)
  J:124885 1 not applicable
Skin carcinoma Skin Chemical/Drug
12-O-tetradecanoylphorbol-13-acetate (TPA)
7,12-dimethylbenz[a]anthracene (DMBA)
  J:91957 1 0
Skin papilloma Skin Chemical/Drug
12-O-tetradecanoylphorbol-13-acetate (TPA)
7,12-dimethylbenz[a]anthracene (DMBA)
  J:91957 1 observed
Spleen normal tissue (control) Spleen None (spontaneous)
  J:94307 1 not applicable
Stomach tumor Stomach None (spontaneous)
  J:52691 1 0
Stomach tumor Stomach Chemical/Drug
rebamipide
  J:52691 1 0
Stomach tumor Stomach Chemical/Drug
N-ethyl-N'-nitro-N-nitroguanidine (ENNG)
  J:52691 1 0
Stomach tumor Stomach Chemical/Drug
rebamipide
N-ethyl-N'-nitro-N-nitroguanidine (ENNG)
  J:52691 1 0
Thymus normal tissue (control) Thymus None (spontaneous)
  J:94307 1 not applicable
Thymus thymoma Thymus Virus
A-MuLV - Abelson murine leukemia virus (A-MuLV-P160)
  J:24306 1 high
Urinary bladder dysplasia Urinary bladder Chemical/Drug
N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
  J:49595 1 50
Urinary bladder hyperplasia Urinary bladder Chemical/Drug
N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
  J:49595 1 observed
Urinary bladder squamous cell carcinoma Urinary bladder Chemical/Drug
N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
  J:49595 1 0
Urinary bladder transitional cell carcinoma Urinary bladder Chemical/Drug
N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)
  J:49595 1 20
(Unspecified organ) tumor (Unspecified organ) None (spontaneous)
  J:242785
J:50296
J:64968
3 0 - low
Other Database Links
Additional information about these mice:
Festing's List of Inbred Strains http://www.informatics.jax.org/external/festing/mouse/docs/C57BL.shtml