Strain SummarySTOCK Ptentm2Mak Tg(KLKB1-cre/ERT2)1Pcn

Strain Name

STOCK Ptentm2Mak Tg(KLKB1-cre/ERT2)1Pcn

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

PSA-Cre-ERT2(tg/0)/PTENL2/L2  •  PTENL2/L2

Description

Homozygous Pten mice carrying the transgene on a mixed C57BL/6 (75%), 129/Sv (15%), FVB/N (10%) bacxkground with contribution from 129P2/OlaHsd from the original ES cells.

Strain Genetics

Tg(KLKB1-cre/ERT2)1Pcn
Tg(KLKB1-cre/ERT2)1Pcn

Models

21 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Prostate gland - Anterior lobe adenocarcinoma - poorly differentiated Prostate gland - Anterior lobe tamoxifen (For inducing expression from mutant alleles)

0

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Anterior lobe atypia Prostate gland - Anterior lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Anterior lobe hyperplasia - focal Prostate gland - Anterior lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Anterior lobe prostatic intraepithelial neoplasia (PIN) Prostate gland - Anterior lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe adenocarcinoma Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

0 - 100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe adenocarcinoma - poorly differentiated Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe atypia Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

observed - 100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe carcinoma - invasive Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe hyperplasia - focal Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

observed - 100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia (PIN) Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

observed - 100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe tumor - malignant Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Dorsolateral lobe tumor - microinvasive Prostate gland - Dorsolateral lobe tamoxifen (For inducing expression from mutant alleles)

0 - 20

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Ventral lobe adenocarcinoma - poorly differentiated Prostate gland - Ventral lobe tamoxifen (For inducing expression from mutant alleles)

0

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Ventral lobe atypia Prostate gland - Ventral lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Ventral lobe hyperplasia - focal Prostate gland - Ventral lobe tamoxifen (For inducing expression from mutant alleles)

observed

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland - Ventral lobe prostatic intraepithelial neoplasia (PIN) Prostate gland - Ventral lobe tamoxifen (For inducing expression from mutant alleles)

observed - 100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland atypia Prostate gland tamoxifen (For inducing expression from mutant alleles)

100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland hyperplasia - focal Prostate gland tamoxifen (For inducing expression from mutant alleles)

100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland lesion Prostate gland

0

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland prostatic intraepithelial neoplasia (PIN) Prostate gland tamoxifen (For inducing expression from mutant alleles)

100

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6

Prostate gland tumor Prostate gland

0

References: Ratnacaram CK, Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2521-6