Strain Summary[not specified]-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor Krastm3Tyj/+ Krt5tm1.1(cre/ERT2)Blh/+ Trp53tm1Brn/+

Strain Name

[not specified]-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor Krastm3Tyj/+ Krt5tm1.1(cre/ERT2)Blh/+ Trp53tm1Brn/+

Strain Type(s)

gene trapped  •  targeted mutation (conditional)  •  targeted mutation (knock-in)

Strain Synonym(s)

Krt5-CreER; LSL-KrasG12D; p53wt/flox; LSL-tdTomato

Description

Heterozygous Krt5, ROSA, Trp53, Kras mice on an unspecified background with possible contributions from 129S6/SvEvTac, C57BL/6NCrl, 129P2/OlaHsd, and 129S4/SvJae.

Strain Genetics

Gt(ROSA)26Sortm14(CAG-tdTomato)Hze / Gt(ROSA)26Sor
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze / Gt(ROSA)26Sor
Krastm3Tyj / Kras+
Krt5tm1.1(cre/ERT2)Blh / Krt5+
Trp53tm1Brn / Trp53+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze / Gt(ROSA)26Sor
Krt5tm1.1(cre/ERT2)Blh / Krt5+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze / Gt(ROSA)26Sor
Krt5tm1.1(cre/ERT2)Blh / Krt5+

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Forestomach - Squamocolumnar junction with the glandular stomach tumor Forestomach - Squamocolumnar junction with the glandular stomach tamoxifen (For inducing expression from mutant alleles)

12.5 - 100

References: Moon H, Nat Commun 2019 May 20;10(1):2225

Forestomach lesion Forestomach tamoxifen (For inducing expression from mutant alleles)

100

References: Moon H, Nat Commun 2019 May 20;10(1):2225

Forestomach squamous cell papilloma Forestomach tamoxifen (For inducing expression from mutant alleles)

100

References: Moon H, Nat Commun 2019 May 20;10(1):2225

Forestomach tumor Forestomach tamoxifen (For inducing expression from mutant alleles)

100

References: Moon H, Nat Commun 2019 May 20;10(1):2225

Forestomach tumor - squamous Forestomach tamoxifen (For inducing expression from mutant alleles)

12.5

References: Moon H, Nat Commun 2019 May 20;10(1):2225