Strain SummaryC57BL/6-Trp53tm4Xu/+

Strain Name

C57BL/6-Trp53tm4Xu/+

Strain Type(s)

targeted mutation (knock-in)

Strain Synonym(s)

p53R248W/+

Description

Heterozygous Trp53 mice on a C57BL/6 background with contribution from 129X1/SvJ and 129S1/Sv.

Strain Genetics

Trp53tm4Xu / Trp53+
Trp53tm4Xu / Trp53+

Models

3 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Leukocyte - Myelocyte (Granulocyte) dysplasia Leukocyte - Myelocyte (Granulocyte)

observed

References: Nabinger SC, Leukemia 2019 Jun;33(6):1535-1539

Leukocyte lymphoma Leukocyte

observed

References: Nabinger SC, Leukemia 2019 Jun;33(6):1535-1539

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

observed

References: Nabinger SC, Leukemia 2019 Jun;33(6):1535-1539