Strain SummaryC57BL/6-Braftm1Mmcm/+ Ptentm2.1Ppp/+

Strain Name

C57BL/6-Braftm1Mmcm/+ Ptentm2.1Ppp/+

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)

Strain Synonym(s)

BrafCA/+;Ptenf/+  •  Brafthyr-V600E;Ptenthyr-Δ/+

Description

Heterozygous Braf, Pten mice on a B6 background with contribution from 129P2/OlaHsd and 129S1/Sv.

Strain Genetics

Ptentm2.1Ppp / Pten+
Braftm1Mmcm / Braf+
Braftm1Mmcm / Braf+

Models

7 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Lung tumor - nodular Lung Adenovirus - recombinant, expressing Cre recombinase

66.67

References: Shimamura M, PLoS One 2018;13(8):e0201365

Thyroid gland adenoma Thyroid gland Adenovirus - recombinant, expressing Cre recombinase

0

References: Shimamura M, PLoS One 2018;13(8):e0201365

Thyroid gland hyperplasia Thyroid gland Adenovirus - recombinant, expressing Cre recombinase

0

References: Shimamura M, PLoS One 2018;13(8):e0201365

Thyroid gland tumor Thyroid gland Adenovirus - recombinant, expressing Cre recombinase

100

References: Shimamura M, PLoS One 2018;13(8):e0201365

Thyroid gland tumor - papillary Thyroid gland Adenovirus - recombinant, expressing Cre recombinase

100

References: Shimamura M, PLoS One 2018;13(8):e0201365

Thyroid gland tumor - solid Thyroid gland Adenovirus - recombinant, expressing Cre recombinase

observed

References: Shimamura M, PLoS One 2018;13(8):e0201365

Thyroid gland tumor - undifferentiated Thyroid gland Adenovirus - recombinant, expressing Cre recombinase

observed

References: Shimamura M, PLoS One 2018;13(8):e0201365