Strain SummaryC57BL/6-Krastm4Tyj/+ Krt19tm1(cre/ERT)Ggu/+ Ptentm2Mak

Strain Name

C57BL/6-Krastm4Tyj/+ Krt19tm1(cre/ERT)Ggu/+ Ptentm2Mak

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)

Strain Synonym(s)

K19CreERT/+; LSL-KrasG12D/+; Ptenflox/flox  •  KKPP

Description

Compound mutant mice. The genetic background of this cohort was stated to be C57BL/6. It may have also contained some 129P2/OlaHsd, 129S4/SvJae, 129S6/SvEvTac, and/or other strain(s).

Strain Genetics

Krt19tm1(cre/ERT)Ggu / Krt19+
Krt19tm1(cre/ERT)Ggu / Krt19+
Krastm4Tyj / Kras+
Krt19tm1(cre/ERT)Ggu / Krt19+

Models

8 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Gallbladder hyperplasia - papillary Gallbladder tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Liver - Bile duct hyperplasia - papillary Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Liver - Bile duct lesion - papillary Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

2 pathology image(s)

Liver tumor Liver tamoxifen (For inducing expression from mutant alleles)

0

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

Lung hyperplasia - papillary Lung tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Pancreas - Duct hyperplasia - papillary Pancreas - Duct tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Pancreas pancreatic intraepithelial neoplasia (PanIN) Pancreas tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Stomach hyperplasia Stomach tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899