Strain SummaryC57BL/6-Albtm1(cre/ERT2)Mtz/+ Krastm4Tyj/+ Ptentm2Mak

Strain Name

C57BL/6-Albtm1(cre/ERT2)Mtz/+ Krastm4Tyj/+ Ptentm2Mak

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)

Strain Synonym(s)

AKPP  •  Alb-CreERT2+; LSL-KrasG12D/+; Ptenflox/flox

Description

Compound mutant mice. The genetic background of this cohort was stated to be C57BL/6. It may have also contained some 129P2/OlaHsd, 129S2/SvPas, 129S4/SvJae, and/or other strain(s).

Strain Genetics

Albtm1(cre/ERT2)Mtz / Alb+
Albtm1(cre/ERT2)Mtz / Alb+
Krastm4Tyj / Kras+
Albtm1(cre/ERT2)Mtz / Alb+

Models

4 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Liver - Bile duct cholangiocarcinoma Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)

0 - observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Liver - Hepatocyte dysplasia Liver - Hepatocyte tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Liver hepatocellular carcinoma Liver tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)

Liver tumor Liver tamoxifen (For inducing expression from mutant alleles)

observed

References: Ikenoue T, Sci Rep 2016 Apr 1;6(None):23899

1 pathology image(s)