Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-12-08
MTB 3.0
 
HelpHelp and Documentation Strain Tumor Overview
Collapsed View
 
Strain
B6;129S7-Trp53tm1Brd
Strain Synonyms -/-  •  B6,129-Trp53tm1Bay  •  C57BL/6-129/Sv p53-/-  •  C57BL/6 x 129/Sv p53-/-  •  C57 X 129 -/-  •  p53-/-  •  p53-nullizygous mice  •  p53-/-  •  mixed C57Bl/6-129/Sv p53-deficient  •  mixed C57BL/6 X 129/Sv p53-deficient  •  p53-/-  •  p53-deficient  •  p53-deficient homozygote  •  p53 homozygote  •  p53 null
Strain Note: Homozygous mice. "p53-/-". The genetic background of this strain is a mixture of C57BL/6 and 129S7/SvEvBrd-Hprt+.
Strain Tumor Overview Expanded View
Tumors 31 unique tumor types displayed.

A tumor group is a set of tumors that share the same tumor name, organ(s) affected, and treatment type.

Tumor Name Organ(s) Affected Treatment Type Number of
Tumor Group Records
Frequency Range
Blood vessel hemangioma Blood vessel None (spontaneous) 1 8.6
Blood vessel hemangiosarcoma Blood vessel None (spontaneous) 3 observed - 20
Blood vessel hemangiosarcoma Liver Chemical/Drug 1 15
Blood vessel hemangiosarcoma Liver None (spontaneous) 1 observed
Bone osteosarcoma Bone None (spontaneous) 3 observed - 3.3
CNS - Brain - Undifferentiated cell glioblastoma CNS - Brain - Undifferentiated cell None (spontaneous) 2 1.1 - 1.7
CNS - Brain - Undifferentiated cell medulloblastoma CNS - Brain - Undifferentiated cell None (spontaneous) 2 1.1 - 1.7
Esophagus adenocarcinoma Esophagus Chemical/Drug 1 0
Esophagus adenocarcinoma Esophagus None (spontaneous) 1 0
Esophagus hyperplasia - diffuse Esophagus Chemical/Drug 1 100
Esophagus papilloma Esophagus Chemical/Drug 1 83.33
Esophagus papilloma Esophagus None (spontaneous) 1 0
Esophagus squamous cell carcinoma Esophagus Chemical/Drug 1 83.33
Esophagus squamous cell carcinoma Esophagus None (spontaneous) 1 0
Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte None (spontaneous) 2 observed
Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte None (spontaneous) 1 observed
Leukocyte lymphoma Leukocyte None (spontaneous) 4 observed - 65
Leukocyte lymphoma Leukocyte Chemical/Drug 1 observed
Leukocyte lymphoma Esophagus Chemical/Drug 1 20
Lung adenoma Lung None (spontaneous) 1 observed
Mammary gland adenocarcinoma Mammary gland None (spontaneous) 3 observed - 1.7
Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast None (spontaneous) 1 observed
Mesodermal cell/mesoblast sarcoma Esophagus Chemical/Drug 1 5
Mesodermal cell/mesoblast sarcoma - undifferentiated Mesodermal cell/mesoblast None (spontaneous) 3 observed - 5.0
PNS - Schwann cell schwannoma - malignant PNS - Schwann cell None (spontaneous) 3 observed - 1.7
Testis gonadoblastoma Testis None (spontaneous) 1 observed
Testis tumor Testis None (spontaneous) 2 4.3 - 6.7
Thymus thymoma Thymus None (spontaneous) 1 observed
(Unspecified organ) preneoplastic lesion (Unspecified organ) None (spontaneous) 1 0
(Unspecified organ) tumor (Unspecified organ) None (spontaneous) 7 observed - 100
(Unspecified organ) tumor (Unspecified organ) Chemical/Drug 1 100
Other Database Links
Information about mice carrying the same mutant allele(s):
Mammary Cancer Comparative Pathology Web Site http://ccm.ucdavis.edu/bcancercd/44/p53-null-schmidt.html