Strain Summary[not specified]-Krastm3Tyj/+ Ptf1atm1.1(cre)Cvw/+ Trp53tm2Tyj/+

Strain Name

[not specified]-Krastm3Tyj/+ Ptf1atm1.1(cre)Cvw/+ Trp53tm2Tyj/+

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)

Strain Synonym(s)

KPC  •  KrasG12D/+:Trp53R172H/+:p48-Cre or KrasG12D/+:Trp53R172H/+:Yapflox/+:p48-Cre

Description

Heterozygous Ptf1a, Kras, Trp53 mutant mice on an unspecified background with possible contribution from 129S4/SvJae, 129X1/SvJ, 129S1/Sv, and 129P2/OlaHsd.

Strain Genetics

Trp53tm2Tyj / Trp53+
Krastm3Tyj / Kras+
Ptf1atm1.1(cre)Cvw / Ptf1a+
Yap1? / Yap1+
Ptf1atm1.1(cre)Cvw / Ptf1a+

Models

10 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Pancreas - Acinar cell metaplasia - ductal Pancreas - Acinar cell

0 - 80

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas - Duct adenocarcinoma - poorly differentiated Pancreas - Duct

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas - Duct neoplasia Pancreas - Duct

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas adenocarcinoma - ductal Pancreas

observed - 100

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas carcinoma Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas lesion - malignant Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas neoplasia Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas pancreatic intraepithelial neoplasia 1 (PanIN1) Pancreas

0 - observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas pancreatic intraepithelial neoplasia 2 (PanIN2) Pancreas

0 - observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas pancreatic intraepithelial neoplasia 3 (PanIN3) Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42