Strain Summary[not specified]-Krastm3Tyj/+ Ptf1atm1.1(cre)Cvw/+ Yap?/+

Strain Name

[not specified]-Krastm3Tyj/+ Ptf1atm1.1(cre)Cvw/+ Yap?/+

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)

Strain Synonym(s)

KC  •  KrasG12D/+:p48-Cre or KrasG12D/+:Yapflox/+:p48- Cre

Description

Heterozygous Ptf1a, Kras, Yap mutant mice on an unspecified background with possible contribution from 129S4/SvJae, 129X1/SvJ, 129S1/Sv, & 129P2/OlaHsd. Yap alleles could be either mutant/wild-type or homozygous wild-type.

Strain Genetics

Krastm3Tyj / Kras+
Ptf1atm1.1(cre)Cvw / Ptf1a+
Yap1? / Yap1+
Ptf1atm1.1(cre)Cvw / Ptf1a+

Models

8 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Pancreas - Acinar cell metaplasia - ductal Pancreas - Acinar cell

0 - observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas adenocarcinoma - ductal Pancreas

observed - 50

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas carcinoma Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas lesion - malignant Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas neoplasia Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas pancreatic intraepithelial neoplasia 1 (PanIN1) Pancreas

0 - observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas pancreatic intraepithelial neoplasia 2 (PanIN2) Pancreas

0 - observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42

Pancreas pancreatic intraepithelial neoplasia 3 (PanIN3) Pancreas

observed

References: Zhang W, Sci Signal 2014 May 6;7(324):ra42