Strain SummaryB6;129-Krastm5(Hras*G12V)Bbd/+ Tg(Cela1-tTA)#Eps Tg(tetO-cre)3Jig Trp53tm1Brn

Strain Name

B6;129-Krastm5(Hras*G12V)Bbd/+ Tg(Cela1-tTA)#Eps Tg(tetO-cre)3Jig Trp53tm1Brn

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

KHRasV12;p53lox/lox;Elas-tTA/tetO-Cre  •  K-Ras+/LSLH-RasG12V;p53lox/lox;Elas-tTA/tetO-Cre

Description

The genetic background of these mice was reported to be mixed 129X1/SvJ x C57BL/6J and may have also included some 129S6/SvEvTac, 129P2/OlaHsd, C57BL/6NCrl, FVB/N, and/or some other strain(s).

Strain Genetics

Krastm5(Hras*G12V)Bbd / Kras+
Tg(tetO-cre)3Jig
Tg(Cela1-tTA)#Eps
Tg(Cela1-tTA)#Eps
Krastm5(Hras*G12V)Bbd / Kras+

Models

3 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Pancreas adenocarcinoma - ductal Pancreas

12.5

References: Drosten M, Cancer Res 2017 Feb 01;77(3):707-718

Pancreas pancreatic intraepithelial neoplasia (PanIN) - high grade Pancreas

62.5

References: Drosten M, Cancer Res 2017 Feb 01;77(3):707-718

Pancreas pancreatic intraepithelial neoplasia (PanIN) - low grade Pancreas

25

References: Drosten M, Cancer Res 2017 Feb 01;77(3):707-718