Strain SummaryB6;129-Krastm5(Hras*G12V)Bbd/+ Trp53tm1Brn

Strain Name

B6;129-Krastm5(Hras*G12V)Bbd/+ Trp53tm1Brn

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)

Strain Synonym(s)

KHRasV12;p53lox/lox  •  K-Ras+/LSLH-RasG12V;p53lox/lox

Description

The genetic background of these mice was reported to be mixed 129X1/SvJ x C57BL/6J and may have also included some 129S6/SvEvTac, 129P2/OlaHsd, and/or C57BL/6NCrl.

Strain Genetics

Krastm5(Hras*G12V)Bbd / Kras+
Krastm5(Hras*G12V)Bbd / Kras+

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Lung adenoma Lung Adenovirus carrying cre recombinase

observed

References: Drosten M, Cancer Res 2017 Feb 01;77(3):707-718

Lung tumor Lung Adenovirus carrying cre recombinase

29.4

References: Drosten M, Cancer Res 2017 Feb 01;77(3):707-718