Strain Summary[not specified]-Gt(ROSA)26Sortm1(cre/ERT2)Alj Igs2tm1(ACTB-EGFP,-tdTomato)Luo/Igs2tm2(ACTB-tdTomato,-EGFP)Luo Krastm3Tyj/+ Trp53tm1Tyj/+

Strain Name

[not specified]-Gt(ROSA)26Sortm1(cre/ERT2)Alj Igs2tm1(ACTB-EGFP,-tdTomato)Luo/Igs2tm2(ACTB-tdTomato,-EGFP)Luo Krastm3Tyj/+ Trp53tm1Tyj/+

Strain Type(s)

targeted mutation (knock-in)  •  targeted mutation (knockout)  •  targeted mutation (other)

Strain Synonym(s)

KrasLA2,Rosa26-CreERT2/KrasWT; MADM11-GT,p53WT/MADM11-TG-p53KO  •  KrasLA2,Rosa26-CreERT2/KrasWT; MADM-p53

Description

Compound mutant mice. The genetic background was an undefined mixture that included at least some 129S4/SvJae, 129S2/SvPas, and also 129X1/SvJ and/or 129S1/Sv. There may have been other strain contributions.

Strain Genetics

Gt(ROSA)26Sortm1(cre/ERT2)Alj
Igs2tm1(ACTB-EGFP,-tdTomato)Luo / Igs2tm2(ACTB-tdTomato,-EGFP)Luo
Trp53tm1Tyj / Trp53+
Igs2tm1(ACTB-EGFP,-tdTomato)Luo / Igs2tm2(ACTB-tdTomato,-EGFP)Luo
Krastm3Tyj / Kras+
Igs2tm1(ACTB-EGFP,-tdTomato)Luo / Igs2tm2(ACTB-tdTomato,-EGFP)Luo
Gt(ROSA)26Sortm1(cre/ERT2)Alj
Igs2tm1(ACTB-EGFP,-tdTomato)Luo / Igs2tm2(ACTB-tdTomato,-EGFP)Luo

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Lung adenocarcinoma Lung tamoxifen (For inducing expression from mutant alleles)

observed

References: Muzumdar MD, Nat Commun 2016 Sep 02;7():12685

Lung adenoma Lung tamoxifen (For inducing expression from mutant alleles)

observed

References: Muzumdar MD, Nat Commun 2016 Sep 02;7():12685