Strain SummaryB6;129-Atmtm2.1Fwa Krastm4Tyj/+ Trp53tm1Brn

Strain Name

B6;129-Atmtm2.1Fwa Krastm4Tyj/+ Trp53tm1Brn

Strain Type(s)

targeted mutation (conditional)

Strain Synonym(s)

KrasLSLG.12D/wt;Tp53fl/fl;Atmfl/fl  •  KPA

Description

Heterozygous Kras, homozygous Atm, Trp53 mice on a mixed C57BL/6, 129/Sv (unspecified strain) background with contribution from 129S4/SvJae, 129P2/OlaHsd, and 129S6/SvEvTac from the parental ES cells.

Strain Genetics

Krastm4Tyj / Kras+

Models

3 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Lung tumor Lung Adenovirus carrying cre recombinase

observed

References: Schmitt A, Cancer Res 2017 Jun 01;77(11):3040-3056

Lung tumor - diffuse Lung Adenovirus carrying cre recombinase

observed

References: Schmitt A, Cancer Res 2017 Jun 01;77(11):3040-3056

Lung tumor - nodular Lung Adenovirus carrying cre recombinase

observed

References: Schmitt A, Cancer Res 2017 Jun 01;77(11):3040-3056