Strain SummarySTOCK Cdkn2atm4Rdp Tg(KRT14-cre/PGR)1Der Trp53tm1Brn/Trp53tm1Glo

Strain Name

STOCK Cdkn2atm4Rdp Tg(KRT14-cre/PGR)1Der Trp53tm1Brn/Trp53tm1Glo

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

Cdkn2af/fp53R172H/f

Description

Heterozygous mutant Trp53, homozygous Cdkn2a mice also carrying the transgene on a mixed C57BL/6, FVB, 129/Sv background with contribution from ICR and 129P2/OlaHsd from the parental ES cells.

Strain Genetics

Tg(KRT5-cre/PGR)1Der
Trp53tm3Glo / Trp53tm1Brn
Tg(KRT5-cre/PGR)1Der

Models

3 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin carcinoma Skin

81.82

References: Li Z, J Pathol 2016 Oct;240(2):224-34

Sites of Metastasis: (Unspecified organ) , Liver , Spleen

Skin tumor Skin

81.82

References: Li Z, J Pathol 2016 Oct;240(2):224-34

Skin tumor - spindle cell Skin

81.82

References: Li Z, J Pathol 2016 Oct;240(2):224-34