Strain SummaryB6;129S6-Krastm1Dsa/+ Tg(Pdx1-flpo)#Dsa Trp53tm1.1Dgk

Strain Name

B6;129S6-Krastm1Dsa/+ Tg(Pdx1-flpo)#Dsa Trp53tm1.1Dgk

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

Pdx1-Flp; FSF-KrasG12D/+; Trp53frt/frt

Description

Heterozygous Kras, homozygous Trp53 mutant mice also carrying the transgene on a mixed C57BL/6, 129S6/SvEv background with contribution from 129S6/SvEvTac, 129X1/SvJ, and 129S1/Sv from the original ES cells.

Strain Genetics

Tg(Pdx1-flpo)#Dsa
Krastm1Dsa / Kras+

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Pancreas - Duct adenocarcinoma - undifferentiated Pancreas - Duct

observed

References: Schonhuber N, Nat Med 2014 Nov;20(11):1340-7

Pancreas - Duct adenocarcinoma - well-differentiated Pancreas - Duct

observed

References: Schonhuber N, Nat Med 2014 Nov;20(11):1340-7