Strain Summary[not specified]-Ptentm2Mak Tg(Nes-cre/ERT2,-ALPP)1Sbk Trp53tm1Brn

Strain Name

[not specified]-Ptentm2Mak Tg(Nes-cre/ERT2,-ALPP)1Sbk Trp53tm1Brn

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

NestincreERT2; PtenloxP/loxP;Trp53loxP/loxP  •  PtencKO;Trp53cKO

Description

Homozygous Pten, Trp53 mutant mice also carrying the transgene on an unspecified background with contribution from 129P2/OlaHsd from the parental ES cells.

Strain Genetics

Tg(Nes-cre/ERT2,-ALPP)1Sbk
Tg(Nes-cre/ERT2,-ALPP)1Sbk
Tg(Nes-cre/ERT2,-ALPP)1Sbk

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
CNS - Brain - Brainstem glioma CNS - Brain - Brainstem

19.23

References: Zhu G, Cancer Res 2017 Jan 01;77(1):123-133

CNS - Brain - Cerebellum medulloblastoma CNS - Brain - Cerebellum

observed - 100

References: Zhu G, Cancer Res 2017 Jan 01;77(1):123-133

CNS - Brain - Cerebellum tumor CNS - Brain - Cerebellum

observed

References: Zhu G, Cancer Res 2017 Jan 01;77(1):123-133

CNS - Brain - Forebrain glioma CNS - Brain - Forebrain

69.23

References: Zhu G, Cancer Res 2017 Jan 01;77(1):123-133

CNS - Brain tumor CNS - Brain

100

References: Zhu G, Cancer Res 2017 Jan 01;77(1):123-133