Strain Summary[not specified]-Cdkn2atm4Rdp Nf1tm1Par

Strain Name

[not specified]-Cdkn2atm4Rdp Nf1tm1Par

Strain Type(s)

targeted mutation (conditional)

Strain Synonym(s)

NF1flox/flox; Ink4a/Arfflox/flox

Description

Homozygous Cdkn2a, Nf1 mutant mice on an unspecified background with possible contribution from FVB/N and C57BL/6 and contributions from the parental ES cells of 129X1/SvJ and 129S1/Sv.

Models

15 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Mesodermal cell/mesoblast sarcoma Muscle Adenovirus carrying cre recombinase

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Mesodermal cell/mesoblast sarcoma PNS - Nerve sheath Adenovirus carrying cre recombinase

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Mesodermal cell/mesoblast sarcoma Muscle Adenovirus carrying cre recombinase   ⋅   PD0325901 (MEK inhibitor)   ⋅   polyethylene glycol 300 (PEG 300)   ⋅   1-methyl-2-pyrrolidone (NMP)

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Mesodermal cell/mesoblast sarcoma Muscle Adenovirus carrying cre recombinase   ⋅   1-methyl-2-pyrrolidone (NMP)   ⋅   polyethylene glycol 300 (PEG 300)

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Mesodermal cell/mesoblast sarcoma - pleomorphic Muscle Adenovirus carrying cre recombinase

50

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Mesodermal cell/mesoblast sarcoma - pleomorphic Muscle Adenovirus carrying cre recombinase   ⋅   PD0325901 (MEK inhibitor)   ⋅   polyethylene glycol 300 (PEG 300)   ⋅   1-methyl-2-pyrrolidone (NMP)

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Mesodermal cell/mesoblast sarcoma - pleomorphic Muscle Adenovirus carrying cre recombinase   ⋅   1-methyl-2-pyrrolidone (NMP)   ⋅   polyethylene glycol 300 (PEG 300)

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Mesodermal cell/mesoblast sarcoma - spindle cell Muscle Adenovirus carrying cre recombinase

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal Adenovirus carrying cre recombinase

50

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal Adenovirus carrying cre recombinase   ⋅   PD0325901 (MEK inhibitor)   ⋅   polyethylene glycol 300 (PEG 300)   ⋅   1-methyl-2-pyrrolidone (NMP)

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal Adenovirus carrying cre recombinase   ⋅   1-methyl-2-pyrrolidone (NMP)   ⋅   polyethylene glycol 300 (PEG 300)

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

Muscle tumor Muscle Adenovirus carrying cre recombinase

observed - 100

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

PNS - Nerve - Sciatic tumor PNS - Nerve - Sciatic Adenovirus carrying cre recombinase

observed - 100

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

PNS - Nerve sheath tumor PNS - Nerve sheath Adenovirus carrying cre recombinase

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17

PNS - Nerve sheath tumor - malignant PNS - Nerve sheath Adenovirus carrying cre recombinase

observed

References: Dodd RD, Mol Cancer Ther 2013 Sep;12(9):1906-17