Strain Summary[not specified]-Cdkn2atm2.1Nesh/+ Krastm4Tyj/+ Tg(Tyr-cre/ERT2)13Bos Trp53tm1Brn/+

Strain Name

[not specified]-Cdkn2atm2.1Nesh/+ Krastm4Tyj/+ Tg(Tyr-cre/ERT2)13Bos Trp53tm1Brn/+

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

Tyr-CRE-ERT2 + KRasLSL/+ p16L/+p53L/+  •  Tyr-CRE-ERT2 Lox-Stop-Lox-KRasG12D p16L/+ p53L/+  •  TKp16L/+p53L/+

Description

Compound mutant mice. The genetic background was not specified but was ~50% C57BL/6 (described as "N1" onto that strain) and may have included some FVB, 129S4/SvJae, 129P2/OlaHsd, and possibly some other strain(s).

Strain Genetics

Tg(Tyr-cre/ERT2)13Bos
Tg(Tyr-cre/ERT2)13Bos
Trp53tm1Brn / Trp53+
Krastm4Tyj / Kras+
Tg(Tyr-cre/ERT2)13Bos
Cdkn2atm2.1Nesh / Cdkn2a+

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Eye - Uvea - Melanocyte melanoma Eye - Uvea - Melanocyte 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

0

References: Monahan KB, Oncogene 2010 Aug 9;():

Skin - Melanocyte melanoma - amelanotic Skin - Melanocyte 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

43

References: Monahan KB, Oncogene 2010 Aug 9;():

Sites of Metastasis: not (Unspecified organ)