Strain SummaryB6;129-Gt(ROSA)26Sortm2(cre/ERT2)Brn Ptentm2Mak Tg(RasE)290Biat

Strain Name

B6;129-Gt(ROSA)26Sortm2(cre/ERT2)Brn Ptentm2Mak Tg(RasE)290Biat

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

RasE>sup>CreER; Ptenflox/flox

Description

Homozygous Ptentm2Mak mice also carrying the Gt(ROSA)26Sortm2(cre/ERT2)Brn and Tg(RasE)290Biat alleles on a mixed C57BL/6 and 129 genetic background with possible contributions from 129P2/OlaHsd and DBA/2.

Strain Genetics

Gt(ROSA)26Sortm2(cre/ERT2)Brn
Tg(RasE)290Biat
Tg(RasE)290Biat
Tg(RasE)290Biat
Tg(RasE)290Biat
Gt(ROSA)26Sortm2(cre/ERT2)Brn

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Lung tumor Lung tamoxifen (For inducing expression from mutant alleles)

100

References: Musteanu M, Nat Methods 2012 Sep;9(9):897-900

Pancreas tumor Pancreas tamoxifen (For inducing expression from mutant alleles)

100

References: Musteanu M, Nat Methods 2012 Sep;9(9):897-900