Strain SummarySTOCK Krastm4Tyj/+ Tg(KRT5-cre/PGR)1Der Trp53tm1Glo/+

Strain Name

STOCK Krastm4Tyj/+ Tg(KRT5-cre/PGR)1Der Trp53tm1Glo/+

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

KrasG12D;p53R172H/+  •  p53R172H/+  •  K5.Cre*PR1/LSL-K-rasG12D/ Neo-p53R172H/WT  •  K-ras-p53R172H/WT

Description

Heterozygous Trp53tm1Glo, Krastm4Tyj mice also carrying the Tg(KRT5-cre/PGR)1Der transgene on a mixed FVB, "129/Sv", and C57BL/6 genetic background.

Strain Genetics

Tg(KRT5-cre/PGR)1Der
Krastm4Tyj / Kras+
Trp53tm1Glo / Trp53+
Tg(KRT5-cre/PGR)1Der

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin carcinoma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   RU-486

90.91

References: Caulin C, J Clin Invest 2007 Jul;117(7):1893-901

Skin papilloma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   RU-486

observed

References: Caulin C, J Clin Invest 2007 Jul;117(7):1893-901

Skin squamous cell carcinoma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   RU-486

observed

References: Caulin C, J Clin Invest 2007 Jul;117(7):1893-901   ⋅   Torchia EC, Oncogene 2012 May 24;31(21):2680-90

Skin tumor Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   RU-486

observed

References: Torchia EC, Oncogene 2012 May 24;31(21):2680-90

Skin tumor - epithelial Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   RU-486

observed

References: Caulin C, J Clin Invest 2007 Jul;117(7):1893-901

Sites of Metastasis: (Unspecified organ) , Lung , Lymph node