Strain Summary[not specified]-Krastm4Tyj/+ Tg(KRT5-cre/PGR)1Der Trp53tm1Glo/+

Strain Name

[not specified]-Krastm4Tyj/+ Tg(KRT5-cre/PGR)1Der Trp53tm1Glo/+

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

K-ras-p53R172H/WT

Description

Mice heterozygous for the Krastm4Tyj and Trp53tm1Glo mutations and also carrying the Tg(KRT5-cre/PGR)1Der transgene on an unspecified background with possible contribution from 129S4/SvJae, ICR, and/or FVB.

Strain Genetics

Tg(KRT5-cre/PGR)1Der
Krastm4Tyj / Kras+
Trp53tm1Glo / Trp53+
Tg(KRT5-cre/PGR)1Der

Models

4 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin carcinoma - spindle cell Skin RU-486

observed

References: Savar A, Oncogene 2015 Jan 22;34(4):516-24

Skin papilloma Skin RU-486

observed

References: Savar A, Oncogene 2015 Jan 22;34(4):516-24

Skin squamous cell carcinoma Skin RU-486

observed

References: Savar A, Oncogene 2015 Jan 22;34(4):516-24

Skin tumor Skin RU-486

observed

References: Savar A, Oncogene 2015 Jan 22;34(4):516-24