Strain SummaryB6.Cg-Ptentm3.1Ppp/+

Strain Name

B6.Cg-Ptentm3.1Ppp/+

Strain Type(s)

congenic  •  targeted mutation (knock-in)

Strain Synonym(s)

cs/+  •  PtenC124S/+  •  PtenC124S/+

Description

Heterozygous mice. The genetic background of these mice was congenic C57BL/6. The ES cells used to generate the mutation were derived from (C57BL/6 x 129S4/SvJae)F1 mice.

Strain Genetics

Ptentm3.1Ppp / Pten+

Models

18 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

85

79.3

References: Papa A, Cell 2014 Apr 24;157(3):595-610

CNS - Brain - Cerebellum hamartoma CNS - Brain - Cerebellum

25.9

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Gallbladder papilloma Gallbladder

60

82.8

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Intestine polyp Intestine

80

82.8

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Leukocyte - Lymphocyte hyperplasia Leukocyte - Lymphocyte

85.7

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Leukocyte - Lymphocyte hyperplasia Lymph node

97.5

100

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Liver adenoma Liver

5.0

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Lung adenoma Lung

observed

observed

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Mammary gland adenocarcinoma Mammary gland

22.5 - 33.3

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Mammary gland hyperplasia Mammary gland

22.5

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Mammary gland lesion Mammary gland

66.7

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Pituitary gland adenoma Pituitary gland

55.6

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Prostate gland adenocarcinoma Prostate gland

24.1

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Prostate gland prostatic intraepithelial neoplasia (PIN) Prostate gland

62.1

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Thyroid gland adenoma Thyroid gland

20

6.9 - 39.3

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Thyroid gland cyst Thyroid gland

55

39.3

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Uterus adenoma Uterus

57.5

References: Papa A, Cell 2014 Apr 24;157(3):595-610

Uterus cyst Uterus

22.5

References: Papa A, Cell 2014 Apr 24;157(3):595-610