Strain SummaryB6;129-Braftm1Mmcm/+ Ptentm1Hwu Tg(TPO-cre/ERT2)1139Tyj

Strain Name

B6;129-Braftm1Mmcm/+ Ptentm1Hwu Tg(TPO-cre/ERT2)1139Tyj

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

TPOCreEr; BrafCA/+; PtenΔ/Δ  •  TPOCreER; BrafCA/+; PtenF/F

Description

Compound mutant mice. The genetic background of these mice was described as mixed C57BL/6 and 129S4/SvJae. It also contained some 129P2/OlaHsd and possibly some other strain(s).

Strain Genetics

Braftm1Mmcm / Braf+
Braftm1Mmcm / Braf+
Tg(TPO-cre/ERT2)1139Tyj
Tg(TPO-cre/ERT2)1139Tyj

Models

1 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Thyroid gland carcinoma - papillary Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

1 pathology image(s)