Strain SummaryB6;129-Braftm1Mmcm/+ Tg(TPO-cre/ERT2)1139Tyj Trp53tm3.1Tyj/+

Strain Name

B6;129-Braftm1Mmcm/+ Tg(TPO-cre/ERT2)1139Tyj Trp53tm3.1Tyj/+

Strain Type(s)

targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

TPOCreEr; BrafCA/+; Trp53LSL-R270H/+  •  TB270/+

Description

Compound mutant mice. The genetic background of these mice was described as mixed C57BL/6 and 129S4/SvJae. It also contained some 129P2/OlaHsd and possibly some other strain(s).

Strain Genetics

Braftm1Mmcm / Braf+
Braftm1Mmcm / Braf+
Tg(TPO-cre/ERT2)1139Tyj
Tg(TPO-cre/ERT2)1139Tyj
Trp53tm3.1Tyj / Trp53+

Models

4 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Thyroid gland carcinoma Thyroid gland tamoxifen (For inducing expression from mutant alleles)

100

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma - anaplastic Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma - papillary Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

1 pathology image(s)

Thyroid gland carcinoma - poorly differentiated Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9