Strain SummaryB6;129-Braftm1Mmcm/+ Tg(TPO-cre/ERT2)1139Tyj Trp53tm1Brn

Strain Name

B6;129-Braftm1Mmcm/+ Tg(TPO-cre/ERT2)1139Tyj Trp53tm1Brn

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

TPOCreEr; BrafCA/+; Trp53Δex2-10/ Δex2-10  •  TPOCreEr; BrafCA/+; Trp53F/F  •  TBP  •  TPOCreER; BrafV600E; p53 -/-

Description

Compound mutant mice. The genetic background of these mice was described as mixed C57BL/6 and 129S4/SvJae. It also contained some 129P2/OlaHsd and possibly some other strain(s).

Strain Genetics

Braftm1Mmcm / Braf+
Braftm1Mmcm / Braf+
Tg(TPO-cre/ERT2)1139Tyj
Tg(TPO-cre/ERT2)1139Tyj

Models

9 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Thyroid gland carcinoma Thyroid gland tamoxifen (For inducing expression from mutant alleles)

91

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma Thyroid gland

0

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma - anaplastic Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Sites of Metastasis: not Lymph node , Lung

26 pathology image(s)

Thyroid gland carcinoma - anaplastic Thyroid gland L-thyroxine   ⋅   tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma - anaplastic Thyroid gland PLX4720 (BRAF inhibitor)   ⋅   tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

5 pathology image(s)

Thyroid gland carcinoma - anaplastic Thyroid gland PD0325901 (MEK inhibitor)   ⋅   PLX4720 (BRAF inhibitor)   ⋅   tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

1 pathology image(s)

Thyroid gland carcinoma - papillary Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

7 pathology image(s)

Thyroid gland carcinoma - papillary Thyroid gland PLX4720 (BRAF inhibitor)   ⋅   tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

1 pathology image(s)

Thyroid gland carcinoma - poorly differentiated Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

1 pathology image(s)