Strain SummaryB6;129-Braftm1Mmcm/+ Tg(TPO-cre/ERT2)1139Tyj

Strain Name

B6;129-Braftm1Mmcm/+ Tg(TPO-cre/ERT2)1139Tyj

Strain Type(s)

targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

TPOCreEr; BrafCA/+  •  TB  •  TPOCreER; BrafV600E

Description

Compound mutant mice. The genetic background of these mice was described as mixed C57BL/6 and 129S4/SvJae. It also contained some 129P2/OlaHsd and possibly some other strain(s).

Strain Genetics

Braftm1Mmcm / Braf+
Braftm1Mmcm / Braf+
Tg(TPO-cre/ERT2)1139Tyj
Tg(TPO-cre/ERT2)1139Tyj

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Thyroid gland carcinoma Thyroid gland tamoxifen (For inducing expression from mutant alleles)

100

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma Thyroid gland

0

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma - anaplastic Thyroid gland tamoxifen (For inducing expression from mutant alleles)

very low

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Thyroid gland carcinoma - papillary Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Sites of Metastasis: not (Unspecified organ) , not Lymph node - Cervical

2 pathology image(s)

Thyroid gland tumor - unclassified Thyroid gland tamoxifen (For inducing expression from mutant alleles)

observed

References: McFadden DG, Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9

Sites of Metastasis: Lung