Strain Summary[not specified]-Cdkn2atm2Brn/+ Krastm1Bbd/+ Tg(Cela1-tTA)#Eps Tg(tetO-cre)3Jig

Strain Name

[not specified]-Cdkn2atm2Brn/+ Krastm1Bbd/+ Tg(Cela1-tTA)#Eps Tg(tetO-cre)3Jig

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

K-Ras+/G12V;Elas-tTA/tetO-Cre;p16Ink4a/ p19Arf+/lox

Description

Heterozygous Kras, Cdkn2a mutant mice also carrying the Tg(Cela1-tTA)#Eps and Tg(tetO-cre)3Jig transgenes on an unspecified background with possible contributions from 129P2/OlaHsd, 129X1/SvJ, 129S1/Sv, C57BL/6, and/or FVB/N.

Strain Genetics

Tg(tetO-cre)3Jig
Tg(Cela1-tTA)#Eps
Cdkn2atm2Brn / Cdkn2a+
Krastm1Bbd / Kras+
Tg(Cela1-tTA)#Eps

Models

3 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Pancreas adenocarcinoma - ductal Pancreas caerulein   ⋅   doxycycline

0

References: Guerra C, Cancer Cell 2011 Jun 14;19(6):728-39

Pancreas pancreatic intraepithelial neoplasia (PanIN) - high grade Pancreas caerulein   ⋅   doxycycline

observed

References: Guerra C, Cancer Cell 2011 Jun 14;19(6):728-39

Pancreas pancreatic intraepithelial neoplasia (PanIN) - low grade Pancreas caerulein   ⋅   doxycycline

observed

References: Guerra C, Cancer Cell 2011 Jun 14;19(6):728-39