Strain Summary[not specified]-Krastm1Bbd/+ Ptentm2Mak Tg(Vil1-cre/ERT2)23Syr

Strain Name

[not specified]-Krastm1Bbd/+ Ptentm2Mak Tg(Vil1-cre/ERT2)23Syr

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

Ptenfl/flKrasLSL/+  •  VillinCreERT-Ptenfl/flKrasLSL/+  •  [not specified]-Krastm1Bbd/+ Ptentm2Mak Tg(Vil-cre/ERT2)23Syr  •  PK

Description

Heterozygous Kras, homozygous Pten mice also carrying the Tg(Vil-cre/ERT2)23Syr transgene on an unspecified background with possible contributions from 129X1/SvJ, 129S1/Sv, 129P2/OlaHsd, C57BL/6, and/or DBA/2.

Strain Genetics

Tg(Vil1-cre/ERT2)23Syr
Tg(Vil1-cre/ERT2)23Syr
Krastm1Bbd / Kras+

Models

8 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine tamoxifen (For inducing expression from mutant alleles)

33.33

References: Davies EJ, J Pathol 2014 May;233(1):27-38

Sites of Metastasis: (Unspecified organ) , Liver , Lung , Lymph node , Pancreas

Intestine - Small Intestine adenoma - serrated Intestine - Small Intestine tamoxifen (For inducing expression from mutant alleles)

58.33

References: Davies EJ, J Pathol 2014 May;233(1):27-38

Intestine - Small Intestine carcinoma Intestine - Small Intestine tamoxifen (For inducing expression from mutant alleles)

30.56

References: Davies EJ, J Pathol 2014 May;233(1):27-38

Sites of Metastasis: (Unspecified organ) , Peritoneum - Visceral

Intestine - Small Intestine lesion Intestine - Small Intestine tamoxifen (For inducing expression from mutant alleles)

observed

References: Davies EJ, J Pathol 2014 May;233(1):27-38

Intestine - Small Intestine polyp - hyperplastic Intestine - Small Intestine tamoxifen (For inducing expression from mutant alleles)

22.22

References: Davies EJ, J Pathol 2014 May;233(1):27-38

Intestine adenocarcinoma Intestine tamoxifen (For inducing expression from mutant alleles)

100

References: Davies EJ, J Pathol 2014 May;233(1):27-38

Intestine adenoma Intestine tamoxifen (For inducing expression from mutant alleles)

observed

References: Davies EJ, J Pathol 2014 May;233(1):27-38

Intestine tumor Intestine tamoxifen (For inducing expression from mutant alleles)

75

References: Davies EJ, J Pathol 2014 May;233(1):27-38